The repressilator is a genetic regulatory network consisting of at least one feedback loop with at least three genes, each expressing a protein that represses the next gene in the loop.[1] In biological research, repressilators have been used to build cellular models and understand cell function. There are both artificial and naturally-occurring repressilators. Recently, the naturally-occurring repressilator clock gene circuit in Arabidopsis thaliana (A. thaliana) and mammalian systems have been studied.
^Oliveira, Samuel M. D.; Chandraseelan, Jerome G.; Häkkinen, Antti; Goncalves, Nadia S. M.; Yli-Harja, Olli; Startceva, Sofia; Ribeiro, Andre S. (2015). "Single-cell kinetics of a repressilator when implemented in a single-copy plasmid". Mol. BioSyst. 11 (7): 1939–1945. doi:10.1039/c5mb00012b. PMID 25923804.
The repressilator is a genetic regulatory network consisting of at least one feedback loop with at least three genes, each expressing a protein that represses...
reframing of the plant circadian clock as a triple negative-component repressilator model rather than the positive/negative-element feedback loop characterizing...
form the Evening Complex (EC), a core component of the Arabidopsis repressilator model of the plant circadian clock. The LUX protein functions as a transcription...
Program for the design of a synthetic gene regulatory network, the Repressilator, which helped initiate the field of synthetic biology. He was the first...
genes could be connected to form a negative feedback loop termed the Repressilator that produces self-sustaining oscillations of protein levels in E. coli...
control mechanism. This set of interests led Paulsson to examine the repressilator, a synthetic gene regulatory network that was designed from scratch...
two inhibitions leading to an activation, it is also referred to as a repressilator. A recently discovered loop includes the reveille (reveille) family...
works in conjunction with the morning complex to form Arabidopsis’ repressilator circadian oscillator. Throughout the day, CCA1 and LHY, morning complex...
CCA/LHY transcription. This can also help account for problems in the repressilator model described below. CCA1 is also unusual in that it has the ability...
Global Information