Rabeprazole, sold under the brand name Aciphex, among others, is a medication that decreases stomach acid.[6] It is used to treat peptic ulcer disease, gastroesophageal reflux disease, and excess stomach acid production such as in Zollinger–Ellison syndrome.[6] It may also be used in combination with other medications to treat Helicobacter pylori.[7] Effectiveness is similar to other proton pump inhibitors (PPIs).[8] It is taken by mouth.[6]
Common side effects include constipation, feeling weak, and throat inflammation.[6] Serious side effects may include osteoporosis, low blood magnesium, Clostridium difficile infection, and pneumonia.[6] Use in pregnancy and breastfeeding is of unclear safety.[1] It works by blocking H+/K+-ATPase in the parietal cells of the stomach.[6]
Rabeprazole was patented in 1986, and approved for medical use in 1997.[9] It is available as a generic medication.[7] In 2017, it was the 288th most commonly prescribed medication in the United States, with more than 1million prescriptions.[10]
^ abc"Rabeprazole Use During Pregnancy". Drugs.com. 25 June 2018. Retrieved 10 January 2020.
^ abcdeCite error: The named reference Marelli Review 2012 was invoked but never defined (see the help page).
^ abLangtry HD, Markham A (October 1999). "Rabeprazole: a review of its use in acid-related gastrointestinal disorders". Drugs. 58 (4): 725–742. doi:10.2165/00003495-199958040-00014. PMID 10551440. S2CID 195691083.
^"Rabeprazole". PubChem. NCBI. Retrieved 10 January 2020.
^"Rabeprazole". PubChem. U.S. National Library of Medicine. Retrieved 10 January 2020.
^ abcdef"Rabeprazole Sodium Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.
^ abBritish national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 82. ISBN 9780857113382.
^"[99] Comparative effectiveness of proton pump inhibitors". Therapeutics Initiative. 28 June 2016. Retrieved 14 July 2016.
^Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 445. ISBN 9783527607495.
^"Rabeprazole - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022.
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