RV 144, or the Thai trial, was an HIV vaccine clinical trial that was conducted in Thailand between 2003 and 2006. It used a combination of two HIV vaccines that had each failed in earlier trials. Participants were vaccinated over the course of 24 weeks beginning in October 2003 and were then tested for HIV until July 2006.[1] The results of the study were publicized in September 2009. The initial report showed that the rate of HIV infection among volunteers who received the experimental vaccine was 31% lower than the rate of HIV infection in volunteers who received the placebo.[2][3] This reduction was not large enough for the Ministry of Public Health in Thailand to support approving the vaccine; it would have licensed it if the reduction had been 50% or more.[4]
The trial collaborators have stated that results of this trial give the first supporting evidence of any vaccine being effective in lowering the risk of contracting HIV.[5] On October 20, 2009, the organizers released full results of the study through publishing in the New England Journal of Medicine and presented them at the AIDS Vaccine Conference in Paris.[2]
^Dolgin, Elie (2009-09-24). "Vaccine protects against HIV virus". Nature News. doi:10.1038/news.2009.947.
^ abRerks-Ngarm, S.; Pitisuttithum, P.; Nitayaphan, S.; Kaewkungwal, J.; Chiu, J.; Paris, R.; Premsri, N.; Namwat, C.; De Souza, M.; Adams, E.; Benenson, M.; Gurunathan, S.; Tartaglia, J.; McNeil, J. G.; Francis, D. P.; Stablein, D.; Birx, D. L.; Chunsuttiwat, S.; Khamboonruang, C.; Thongcharoen, P.; Robb, M. L.; Michael, N. L.; Kunasol, P.; Kim, J. H.; Moph-Taveg, I. (2009). "Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand". New England Journal of Medicine. 361 (23): 2209–2220. doi:10.1056/NEJMoa0908492. PMID 19843557.
^"HIV Vaccine Study First to Show Some Effectiveness in Preventing HIV". US Military HIV Research Program. Archived from the original on September 27, 2009. Retrieved 2009-09-24.
^Walker, Molly (3 December 2019). "The Moon Landing of HIV Vaccine Research: RV144, Ten Years Later". MedPage Today. Retrieved 21 May 2020.
^McNeil Jr, Donald G. (2009-09-25). "For First Time, AIDS Vaccine Shows Some Success". New York Times. Retrieved 2009-09-24.
RV144, or the Thai trial, was an HIV vaccine clinical trial that was conducted in Thailand between 2003 and 2006. It used a combination of two HIV vaccines...
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Kim led the US Army's advanced development program for HIV vaccines, the RV144 HIV vaccine trial, and a molecular virology laboratory at Walter Reed Army...
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announced the start of the research. HVTN 702 was based on outcomes of the RV144 trial. Doughton, Sandi (3 February 2020). "'Incredibly disappointing': Fred...
of Einsteinium-254". Physical Review. 144 (3): 1031–1045. Bibcode:1966PhRv..144.1031M. doi:10.1103/PhysRev.144.1031. Institut de Radioprotection et de...
program's most notable contribution to HIV/AIDS medical research was the RV144 vaccine study of over 16,000 volunteers in Thailand. In September 2009,...
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Properties of La F 3". Physical Review. 144 (2): 593–604. Bibcode:1966PhRv..144..593S. doi:10.1103/PhysRev.144.593. Rodríguez-de Marcos, Luis (23 September...
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