Predicted secondary structure and sequence conservation of RNase_MRP
Identifiers
Symbol
RNase MRP
Rfam
RF00030
Other data
RNA type
Gene; ribozyme
Domain(s)
Eukaryota
GO
GO:0006364 GO:0000171 GO:0000172
SO
SO:0000385
PDB structures
PDBe
RNase MRP (also called RMRP) is an enzymatically active ribonucleoprotein with two distinct roles in eukaryotes. RNAse MRP stands for RNAse for mitochondrial RNA processing. In mitochondria it plays a direct role in the initiation of mitochondrial DNA replication. In the nucleus it is involved in precursor rRNA processing, where it cleaves the internal transcribed spacer 1 between 18S and 5.8S rRNAs.[1] Despite distinct functions, RNase MRP has been shown to be evolutionarily related to RNase P. Like eukaryotic RNase P, RNase MRP is not catalytically active without associated protein subunits.[2]
Mutations in the RNA component of RNase MRP cause cartilage–hair hypoplasia, a pleiotropic human disease. Responsible for this disease is a mutation in the RNase MRP RNA gene (RMRP), a non-coding RNA gene. RMRP was the first non-coding nuclear RNA gene found to cause disease.[3]
^Li X, Frank DN, Pace N, Zengel JM, Lindahl L (June 2002). "Phylogenetic analysis of the structure of RNase MRP RNA in yeasts". RNA. 8 (6): 740–51. doi:10.1017/S1355838202022082. PMC 1370293. PMID 12088147.
^Kiss T, Marshallsay C, Filipowicz W (October 1992). "7-2/MRP RNAs in plant and mammalian cells: association with higher order structures in the nucleolus". The EMBO Journal. 11 (10): 3737–46. doi:10.1002/j.1460-2075.1992.tb05459.x. PMC 556834. PMID 1382978.
^Cite error: The named reference Brian was invoked but never defined (see the help page).
RNaseMRP (also called RMRP) is an enzymatically active ribonucleoprotein with two distinct roles in eukaryotes. RNAseMRP stands for RNAse for mitochondrial...
French Republic Micronized rubber powder Multidrug resistance protein RNaseMRP, a ribonucleoprotein Multilevel regression with poststratification, used...
eucaryal RNase P have a minor contribution to tRNA processing per se, while they seem to be essential for the function of RNase P and RNaseMRP in other...
occurs by processing of light strand transcripts with the Mitochondrial RNaseMRP (Mitochondrial RNA Processing). The requirement of transcription to produce...
WJ, Pruijn GJ (Aug 2001). "hPop5, a protein subunit of the human RNaseMRP and RNase P endoribonucleases" (PDF). J Biol Chem. 276 (34): 31635–41. doi:10...
Venrooij WJ (June 1999). "hPop4: a new protein subunit of the human RNaseMRP and RNase P ribonucleoprotein complexes". Nucleic Acids Research. 27 (12):...
III include: Transfer RNAs 5S ribosomal RNA U6 spliceosomal RNA RNase P and RNaseMRP RNA 7SL RNA (the RNA component of the signal recognition particle)...
the catalytical reaction. In eukaryotes, in particular a snoRNP called RNase, MRP cleaves the 45S pre-rRNA into the 28S, 5.8S, and 18S rRNAs. The rRNA and...
semi-conserved/highly variable structure, other notable RNAs include RNAse P, RNAseMRP, telomerase RNA, and 7SK RNA. Vault (organelle) Major vault protein...
of the three. FAM221B is linked to mutations in the RNA component of RNaseMRP, which causes pleiotropic human disease cartilage–hair hypoplasia. Also...
ribonuclease P/MRP 38kDa subunit". Welting TJ, van Venrooij WJ, Pruijn GJ (2004). "Mutual interactions between subunits of the human RNaseMRP ribonucleoprotein...
Pruijn GJ (2004). "Mutual interactions between subunits of the human RNaseMRP ribonucleoprotein complex". Nucleic Acids Res. 32 (7): 2138–2146. doi:10...
conserved members of the RNase D family have unique and overlapping functions in the processing of 5S, 5.8S, U4, U5, RNaseMRP and RNase P RNAs in yeast". The...
ribosomal RNA (pre-RNA) processing. More specifically, Ribonuclease (RNase) MRP was the identified protein. Lygerou, using fission yeast, identified that...
including U19, are not confirmed. Co-precipitation of U19 snoRNA with RNaseMRP RNA suggests that U19 may be involved in pre-rRNA processing. Ganot P...
Pruijn GJ (2004). "Mutual interactions between subunits of the human RNaseMRP ribonucleoprotein complex". Nucleic Acids Res. 32 (7): 2138–46. doi:10...
Pruijn GJ (2004). "Mutual interactions between subunits of the human RNaseMRP ribonucleoprotein complex". Nucleic Acids Res. 32 (7): 2138–46. doi:10...
Pruijn GJ (2004). "Mutual interactions between subunits of the human RNaseMRP ribonucleoprotein complex". Nucleic Acids Res. 32 (7): 2138–46. doi:10...
domain-containing protein 3 RHOA RhoA Ras Homolog Family Member A RNASEL RNAse L Ribonuclease L RNF214 RNF214 RING finger protein 214 RNF219 RNF219 RING...
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