Recombination activating gene 2protein (also known as RAG-2) is a lymphocyte-specific protein encoded by RAG2 gene on human chromosome 11. Together with RAG1 protein, RAG2 forms a V(D)J recombinase, a protein complex required for the process of V(D)J recombination during which the variable regions of immunoglobulin and T cell receptor genes are assembled in developing B and T lymphocytes. Therefore, RAG2 is essential for generation of mature B and T lymphocytes.
^ abcGRCh38: Ensembl release 89: ENSG00000175097 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000032864 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
a lymphocyte-specific protein encoded by RAG2 gene on human chromosome 11. Together with RAG1 protein, RAG2 forms a V(D)J recombinase, a protein complex...
RAG-1 is a protein that in humans is encoded by the RAG1 gene. The RAG1 and RAG2 genes are largely conserved in humans. 55.99% and 55.98% of the encoded amino...
are conserved sequences of noncoding DNA that are recognized by the RAG1/RAG2 enzyme complex during V(D)J recombination in immature B cells and T cells...
of the major groups of catfish (Teleostei: Siluriformes) using rag1 and rag2 nuclear gene sequences". Mol Phylogenet Evol. 41 (3): 636–62. Bibcode:2006MolPE...
of T-cells (and B-cells) such as recombination activating genes (RAG1 and RAG2), Interleukin-7 receptor-α (IL7Rα), DCLRE1C-Artemis, RMRP-CHH, DNA-Ligase...
DN2 stage (CD44+CD25+), cells upregulate the recombination genes RAG1 and RAG2 and re-arrange the TCRβ locus, combining V-D-J recombination and constant...
genes associated with immunodeficiency diseases include CD40L, CD40, RAG1, RAG2, IL2RG, and ADA. Here is a summary of some methods utilized to identify genetic...
complete defects in the immune system have been constructed (e.g. RAG1 and RAG2 knockout mice). For these reasons, nude mice are less popular in research...
process of V(D)J recombination gene rearrangement stimulated by RAG1 and RAG2 genes. This process is error-prone, and some thymocytes fail to make functional...
of the major groups of catfishes (Teleostei: Siluriformes) using rag1 and rag2 nuclear gene sequences". Mol Phylogenet Evol. 41 (3): 636–62. doi:10.1016/j...
of the major groups of catfishes (Teleostei: Siluriformes) using rag1 and rag2 nuclear gene sequences". Mol Phylogenet Evol. 41 (3): 636–62. doi:10.1016/j...
cells prevents the development of xenogeneic graft-versus-host disease in Rag2-/-gamma c-/- double knockout mice". Transfusion. 46 (9): 1553–1560. doi:10...
of the major groups of catfishes (Teleostei: Siluriformes) using rag1 and rag2 nuclear gene sequences". Mol. Phylogenet. Evol. 41 (3): 636–62. doi:10.1016/j...
of the major groups of catfishes (Teleostei: Siluriformes) using rag1 and rag2 nuclear gene sequences". Mol Phylogenet Evol. 41 (3): 636–62. doi:10.1016/j...
of the major groups of catfishes (Teleostei: Siluriformes) using rag1 and rag2 nuclear gene sequences". Mol Phylogenet Evol. 41 (3): 636–62. doi:10.1016/j...
revision is achieved via reactivation of recombination enzymes RAG1 and/or RAG2 after T cell activation in the periphery and random recombination of their...
rash, slenomegaly, and lymphadenopathy due to a causative mutation in RAG1, RAG2, or, more rarely, one of several other genes. Lymphocyte-variant hypereosinophilia...
this, it has been hypothesized that these proteins, particularly Rag1 and Rag2 are derived from transposable elements. There is evidence suggesting that...
and IL-21. Researchers evolved this NSG model by knocking out the RAG1 and RAG2 genes (recombination activation genes), resulting into the RAGnull version...
of the major groups of catfishes (Teleostei: Siluriformes) using rag1 and rag2 nuclear gene sequences". Mol Phylogenet Evol. 41 (3): 636–62. doi:10.1016/j...
motifs that are structurally similar to recombination activating gene 2 (RAG2), a protein involved in the activation of the V(D)J recombination. This gene...
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