Drugs that promote rapid and sustained neuroplasticity
Psychoplastogens are a group of small molecule drugs that produce rapid and sustained effects on neuronal structure and function, intended to manifest therapeutic benefit after a single administration.[1][2] Several existing psychoplastogens have been identified and their therapeutic effects demonstrated; several are presently at various stages of development as medications including Ketamine, MDMA, Scopolamine, and the serotonergic psychedelics, including LSD, psilocin (the active metabolite of psilocybin), DMT, and 5-MeO-DMT. Compounds of this sort are being explored as therapeutics for a variety of brain disorders including depression, addiction, and PTSD. The ability to rapidly promote neuronal changes via mechanisms of neuroplasticity was recently discovered as the common therapeutic activity and mechanism of action.[3]
^Olson DE (January 2018). "Psychoplastogens: A Promising Class of Plasticity-Promoting Neurotherapeutics". Journal of Experimental Neuroscience. 12: 1179069518800508. doi:10.1177/1179069518800508. PMC 6149016. PMID 30262987.
^Benko J, Vranková S (March 2020). "Natural Psychoplastogens As Antidepressant Agents". Molecules. 25 (5): 1172. doi:10.3390/molecules25051172. PMC 7179157. PMID 32150976.
^Ly C, Greb AC, Cameron LP, Wong JM, Barragan EV, Wilson PC, et al. (June 2018). "Psychedelics Promote Structural and Functional Neural Plasticity". Cell Reports. 23 (11): 3170–3182. doi:10.1016/j.celrep.2018.05.022. PMC 6082376. PMID 29898390.
Psychoplastogens are a group of small molecule drugs that produce rapid and sustained effects on neuronal structure and function, intended to manifest...
is a member of the class of compounds known as non-hallucinogenic psychoplastogens. This compound, as well as related compounds, are licensed by Delix...
potential in treating treatment-resistant depression. Ketamine is a known psychoplastogen, which refers to a compound capable of promoting rapid and sustained...
MDMA-assisted psychotherapy. In 2018 researchers identified MDMA as a psychoplastogen which refers to a compound capable of promoting neuroplasticity and...
syndrome, and Down syndrome. Scopolamine has been identified as a psychoplastogen, which refers to a compound capable of promoting rapid and sustained...
small studies. Recently, researchers discovered that LSD is a potent psychoplastogen, a compound capable of promoting rapid and sustained neural plasticity...
that achieve therapeutic effects through neuroplasticity, the term psychoplastogen was introduced. Activity-dependent plasticity Brain training Environmental...
psilocybin. Psilocybin can be produced de novo in GM yeast. Psilocybin is a psychoplastogen, which refers to a compound capable of promoting rapid and sustained...
biotech company that develops psychedelic-inspired medicines known as psychoplastogens and therapies to address addiction and mental illness. MindMed was...
Additionally, researchers discovered that many psychedelics are potent psychoplastogens, compounds capable of promoting rapid and sustained neural plasticity...
Psychedelic microdosing Rick Doblin Robin Carhart-Harris Roland R. Griffiths Psychoplastogen MDMA and Ketamine are not a classical psychedelics but are sometimes...
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