This article is about the eye ailment. For the plastic-based plumbing pipe, see PEX.
Medical condition
Pseudoexfoliation syndrome
Other names
pseudoexfoliation of the lens, exfoliation syndrome
Specialty
Ophthalmology
Pseudoexfoliation syndrome, often abbreviated as PEX[1] and sometimes as PES or PXS, is an aging-related systemic disease manifesting itself primarily in the eyes which is characterized by the accumulation of microscopic granular amyloid-like protein fibers.[2] Its cause is unknown, although there is speculation that there may be a genetic basis. It is more prevalent in women than men, and in persons past the age of seventy. Its prevalence in different human populations varies; for example, it is prevalent in Scandinavia.[2] The buildup of protein clumps can block normal drainage of the eye fluid called the aqueous humor and can cause, in turn, a buildup of pressure leading to glaucoma and loss of vision[3] (pseudoexfoliation glaucoma, exfoliation glaucoma). As worldwide populations become older because of shifts in demography, PEX may become a matter of greater concern.[4]
^"Glaucoma In-Depth Report". The New York Times. 2011-07-09. Retrieved 2011-07-09. Pseudoexfoliation (PEX) syndrome ... The substance is composed of proteins produced by the lens, iris, and other parts of the eye. People can have this condition and not develop glaucoma, but they are at high risk.
^ abYichieh Shiuey, MD (March 26, 1997). "Glaucoma Quiz 1". Digital Journal of Ophthalmology. Retrieved 2011-08-21. ... In Scandinavia, this condition represents greater than 50% of all cases of open angle glaucoma.
^"Glaucoma". The New York Times. 2011-08-19. Retrieved 2011-08-19. ... Pseudoexfoliation (PEX) syndrome (also known as exfoliation syndrome) is the most common identifiable condition associated with glaucoma. The substance is composed of proteins produced by the lens, iris, and other parts of the eye.
^Cite error: The named reference twsO17 was invoked but never defined (see the help page).
and 16 Related for: Pseudoexfoliation syndrome information
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the family. Polymorphisms of the LOXL1 gene are associated with pseudoexfoliationsyndrome, a disease where the extracellular matrix contains abnormal amounts...
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S2CID 8139305. Bernstein AM, Ritch R, Wolosin JM (July 2018). "Exfoliation syndrome: A disease of autophagy and LOXL1 proteopathy". Journal of Glaucoma. 27...
also be associated with other causes of small pupil like synechiae, pseudoexfoliation and other medications (used for conditions such as glaucoma, diabetes...
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condition is identified as open-angle or angle-closure glaucoma. With pseudoexfoliation glaucoma (also known as PEX or exfoliation glaucoma) the pressure...
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