Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
Protopanaxadiol (PPD) is an organic compound that is an aglycone of ginsenosides, a group of steroid glycosides. It is a dammarane-type tetracyclic terpene sapogenin found in ginseng (Panax ginseng) and in notoginseng (Panax pseudoginseng).[1][2]
The health effects of protopanaxadiol inside the human body is still unclear. One study suggests it has rapid, non-genomic effects on endothelial cells, binding to the glucocorticoid and oestrogen beta receptors. The study also showed an increase in intracellular calcium ion concentration.[3]
^Shibata, S.; Tanaka, O.; Sado, M.; Tsushima, S. (1963). "The genuine sapogenin of ginseng". Tetrahedron Letters. 4 (12): 795–800. doi:10.1016/S0040-4039(01)90718-X.
^Tanaka, O.; Nagai, M.; Shibata, S. (1964). "Stereochemistry of protopanaxadiol, a genuine sapogenin of ginseng". Tetrahedron Letters. 5 (33–34): 2291–7. doi:10.1016/S0040-4039(00)71705-9.
^Leung; et al. (2009). "Protopanaxadiol and protopanaxatriol bind to glucocorticoid and oestrogen receptors in endothelial cells". British Journal of Pharmacology. 156 (4): 626–637. doi:10.1111/j.1476-5381.2008.00066.x. PMC 2697710. PMID 19226254.
Protopanaxadiol (PPD) is an organic compound that is an aglycone of ginsenosides, a group of steroid glycosides. It is a dammarane-type tetracyclic terpene...
Dammarane-type ginsenosides includes 2 classifications: the 20(S)-protopanaxadiol (ppd) and 20(S)-protopanaxatriol (ppt) classifications. P. notoginseng...
family. The dammaranes further subdivided into 2 main groups, the protopanaxadiols and protopanaxatriols, with other smaller groups such as the ocotillol-type...
constituents. Dammarane-type ginsenosides include two classifications: 20(S)-protopanaxadiol (PPD) and 20(S)-protopanaxatriol (PPT). American ginseng contains high...
triterpenoid saponins) like those of ginseng (ginsenosides: panaxatriol and protopanaxadiol). Compounds of the series were first isolated from and named after...
These compounds are often composed of saponins, examples include Protopanaxadiol and triol, Dammarenediol I and II. Dammarenediol II synthase Chun JH...
Sphagnum auriculatum bog pool community 20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol, a ppd-type monoglucoside ginsenoside metabolized by intestinal bacteria...
alkaloids, and calcium phosphate – all components of Chinese yam. Protopanaxadiol and panaxatriol, sapogenins found in ginseng (Panax ginseng) and notoginseng...
pseudoginseng). It is formed by the dehydration of protopanaxatriol. Protopanaxadiol Kang, Soo Yeon; Schini-Kerth, Valérie B.; Kim, Nak Doo (1995). "Ginsenosides...
(Panax ginseng) and in notoginseng (Panax pseudoginseng). Panaxatriol Protopanaxadiol Kang, Soo Yeon; Schini-Kerth, Valérie B.; Kim, Nak Doo (1995). "Ginsenosides...
depressant, a chemical added to crude oil to lower its "pour point" ppd, Protopanaxadiol, a molecule Psychogenic polydipsia, excessive water intake with a psychiatric...
The constituents of ginseng include triterpene saponins, aglycone protopanaxadiol, aglycone protopanaxytriol, aglycone oleanolic acid and water-soluble...
synthase (DS) as the catalyst. The dammarenediol-II is converted to protopanaxadiol and then to ginsenoside Rd. Finally, GRb1 is synthesized from ginsenoside...
Zhang, W (March 2013). "Two novel hydroperoxylated products of 20(S)-protopanaxadiol produced by Mucor racemosus and their cytotoxic activities against...
"potently kill colorectal cancer cells". Specifically, derivatives of protopanaxadiol Rg3 and Rh2, are the key ginsenosides found in the extract. In colorectal...
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