Prolyl isomerase (also known as peptidylprolyl isomerase or PPIase) is an enzyme (EC 5.2.1.8) found in both prokaryotes and eukaryotes that interconverts the cis and trans isomers of peptide bonds with the amino acid proline.[1] Proline has an unusually conformationally restrained peptide bond due to its cyclic structure with its side chain bonded to its secondary amine nitrogen. Most amino acids have a strong energetic preference for the trans peptide bond conformation due to steric hindrance, but proline's unusual structure stabilizes the cis form so that both isomers are populated under biologically relevant conditions. Proteins with prolyl isomerase activity include cyclophilin, FKBPs, and parvulin, although larger proteins can also contain prolyl isomerase domains.
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Prolylisomerase (also known as peptidylprolyl isomerase or PPIase) is an enzyme (EC 5.2.1.8) found in both prokaryotes and eukaryotes that interconverts...
Lipoprotein rotamase A (SlrA), also known as peptidyl prolylisomerase A (PpiA), functions as a molecular chaperone that operates within the Streptococcus...
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 is an enzyme that in humans is encoded by the PIN1 gene. Pin 1, or peptidyl-prolyl cis/trans isomerase (PPIase)...
FK506 binding proteins, constitute a family of proteins that have prolylisomerase activity and are related to the cyclophilins in function, though not...
by the PPIA gene on chromosome 7. As a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, this protein catalyzes the cis-trans isomerization...
All organisms possess prolylisomerase enzymes to catalyze this isomerization, and some bacteria have specialized prolylisomerases associated with the...
Peptidyl-prolyl cis-trans isomerase FKBP1A is an enzyme that in humans is encoded by the FKBP1A gene. It is also commonly referred to as FKBP-12 or FKBP12...
In biochemistry, isomerases are a general class of enzymes that convert a molecule from one isomer to another. Isomerases facilitate intramolecular rearrangements...
They are found in all domains of life. These proteins have peptidyl prolylisomerase activity, which catalyzes the isomerization of peptide bonds from trans...
molecular biology, immunophilins are endogenous cytosolic peptidyl-prolylisomerases (PPI) that catalyze the interconversion between the cis and trans...
protein folding and trafficking. This encoded protein is a cis-trans prolylisomerase that binds to the immunosuppressants tacrolimus (FK506) and sirolimus...
Peptidyl-prolyl cis-trans isomerase B is an enzyme that is encoded by the PPIB gene. As a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family...
able to occupy both cis and trans isomers of its prolyl peptide bonds with ease. Peptidyl-prolylisomerase, or PPIase, is an enzyme very commonly associated...
Peptidyl-prolyl cis-trans isomerase-like 1 is an enzyme that in humans is encoded by the PPIL1 gene. This gene is a member of the cyclophilin family of...
of the parvulin family of peptidyl-prolyl-cis/trans-isomerases (PPIases) in humans, which possesses prolylisomerase activity. In 1999, Par14 was identified...
FKBP14 is a gene which codes for a structural protein named FKBP prolylisomerase 14. This protein is believed to aid in the process of procollagen folding...
prolylisomerase activity, which catalyzes the cis-trans isomerization of proline peptide bonds. Although parvulin has no homology with larger prolyl...
exhibited immunosuppressive properties by inhibiting the peptidyl–prolylisomerase activity of cyclophilin, ultimately preventing organ transplant rejections...
for lowering the activation energy have been observed in peptidyl prolylisomerases (PPIases), which are naturally occurring enzymes that catalyze the...
by the PPID gene on chromosome 4. As a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, this protein catalyzes the cis-trans isomerization...
Peptidyl-prolyl cis-trans isomerase, mitochondrial (PPIF) is an enzyme that in humans is encoded by the PPIF gene. It has also been referred to as, but...
Peptidyl-prolyl cis-trans isomerase FKBP1B is an enzyme that in humans is encoded by the FKBP1B gene. The protein encoded by this gene is a member of the...
protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase family. It is located in endoplasmic reticulum and acts as molecular...
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