Peptidylprolyl isomerase A information

PPIA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AK4, 1AWQ, 1AWR, 1AWS, 1AWT, 1AWU, 1AWV, 1BCK, 1CWA, 1CWB, 1CWC, 1CWF, 1CWH, 1CWI, 1CWJ, 1CWK, 1CWL, 1CWM, 1CWO, 1FGL, 1M63, 1M9C, 1M9D, 1M9E, 1M9F, 1M9X, 1M9Y, 1MF8, 1MIK, 1NMK, 1OCA, 1RMH, 1VBS, 1VBT, 1W8L, 1W8M, 1W8V, 1YND, 1ZKF, 2ALF, 2CPL, 2CYH, 2MZU, 2N0T, 2RMA, 2RMB, 2X25, 2X2A, 2X2C, 2X2D, 2XGY, 3CYH, 3CYS, 3K0M, 3K0N, 3K0O, 3K0P, 3K0Q, 3K0R, 3ODI, 3ODL, 3RDD, 4CYH, 4IPZ, 4N1M, 4N1N, 4N1O, 4N1P, 4N1Q, 4N1R, 4N1S, 4YUO, 5CYH, 2MS4, 4YUG, 4YUH, 4YUI, 4YUJ, 4YUK, 4YUL, 4YUM, 4YUN, 4YUP, 5F66, 5FJB
Identifiers
Aliases	PPIA, CYPA, CYPH, HEL-S-69p, Peptidylprolyl isomerase A
External IDs	OMIM: 123840; MGI: 97749; HomoloGene: 134504; GeneCards: PPIA; OMA:PPIA - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	44,824,564 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; right frontal lobe; ; mucosa of transverse colon; ; anterior cingulate cortex; ; right hemisphere of cerebellum; ; ganglionic eminence; ; stromal cell of endometrium; ; rectum; ; C1 segment; ; upper lobe of left lung;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; virion binding; unfolded protein binding; isomerase activity; peptidyl-prolyl cis-trans isomerase activity; RNA binding; cyclosporin A binding;
Cellular component	cytoplasm; nucleus; membrane; focal adhesion; cytosol; extracellular region; secretory granule lumen; ficolin-1-rich granule lumen; vesicle; extracellular exosome; extracellular space; protein-containing complex;
Biological process	viral life cycle; positive regulation of protein secretion; regulation of viral genome replication; uncoating of virus; lipid droplet organization; virion assembly; leukocyte migration; RNA-dependent DNA biosynthetic process; positive regulation of viral genome replication; viral release from host cell; establishment of integrated proviral latency; protein peptidyl-prolyl isomerization; protein folding; fusion of virus membrane with host plasma membrane; viral process; neutrophil degranulation; interleukin-12-mediated signaling pathway; protein refolding;
	Sources:Amigo / QuickGO
Orthologs
	5478
	268373
	ENSG00000196262
	ENSMUSG00000071866
	P62937
	P17742
	NM_203431; NM_001300981; NM_021130; NM_203430
	NM_008907
	NP_001287910; NP_066953
	NP_032933
	Wikidata
View/Edit Human	View/Edit Mouse

Peptidylprolyl isomerase A (PPIA), also known as cyclophilin A (CypA) or rotamase A is an enzyme that in humans is encoded by the PPIA gene on chromosome 7.^[4]^[5]^[6] As a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, this protein catalyzes the cis-trans isomerization of proline imidic peptide bonds, which allows it to regulate many biological processes, including intracellular signaling, transcription, inflammation, and apoptosis.^[4]^[7]^[8]^[9]^[10] Due to its various functions, PPIA has been implicated in a broad range of inflammatory diseases, including atherosclerosis and arthritis, and viral infections.^[8]^[9]^[10]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000196262 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: PPIA peptidylprolyl isomerase A (cyclophilin A)".
^ Haendler B, Hofer E (Jul 1990). "Characterization of the human cyclophilin gene and of related processed pseudogenes". European Journal of Biochemistry. 190 (3): 477–82. doi:10.1111/j.1432-1033.1990.tb15598.x. PMID 2197089.
^ Holzman TF, Egan DA, Edalji R, Simmer RL, Helfrich R, Taylor A, Burres NS (Feb 1991). "Preliminary characterization of a cloned neutral isoelectric form of the human peptidyl prolyl isomerase cyclophilin". The Journal of Biological Chemistry. 266 (4): 2474–9. doi:10.1016/S0021-9258(18)52268-7. PMID 1989998.
^ Kazui T, Inoue N, Yamada O, Komatsu S (Jan 1992). "Selective cerebral perfusion during operation for aneurysms of the aortic arch: a reassessment". The Annals of Thoracic Surgery. 53 (1): 109–14. doi:10.1016/0003-4975(92)90767-x. PMID 1530810.
^ ^a ^b Ramachandran S, Venugopal A, Kutty VR, A V, G D, Chitrasree V, Mullassari A, Pratapchandran NS, Santosh KR, Pillai MR, Kartha CC (7 February 2014). "Plasma level of cyclophilin A is increased in patients with type 2 diabetes mellitus and suggests presence of vascular disease". Cardiovascular Diabetology. 13: 38. doi:10.1186/1475-2840-13-38. PMC 3922405. PMID 24502618.
^ ^a ^b Wei Y, Jinchuan Y, Yi L, Jun W, Zhongqun W, Cuiping W (Jun 2013). "Antiapoptotic and proapoptotic signaling of cyclophilin A in endothelial cells". Inflammation. 36 (3): 567–72. doi:10.1007/s10753-012-9578-7. PMID 23180369. S2CID 24968009.
^ ^a ^b Hoffmann H, Schiene-Fischer C (Jul 2014). "Functional aspects of extracellular cyclophilins". Biological Chemistry. 395 (7–8): 721–35. doi:10.1515/hsz-2014-0125. PMID 24713575. S2CID 32395688.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000196262 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: PPIA peptidylprolyl isomerase A (cyclophilin A)".

[pmid2197089-5] Haendler B, Hofer E (Jul 1990). "Characterization of the human cyclophilin gene and of related processed pseudogenes". European Journal of Biochemistry. 190 (3): 477–82. doi:10.1111/j.1432-1033.1990.tb15598.x. PMID 2197089.

[pmidpmid1989998-6] Holzman TF, Egan DA, Edalji R, Simmer RL, Helfrich R, Taylor A, Burres NS (Feb 1991). "Preliminary characterization of a cloned neutral isoelectric form of the human peptidyl prolyl isomerase cyclophilin". The Journal of Biological Chemistry. 266 (4): 2474–9. doi:10.1016/S0021-9258(18)52268-7. PMID 1989998.

[pmid1530810-7] Kazui T, Inoue N, Yamada O, Komatsu S (Jan 1992). "Selective cerebral perfusion during operation for aneurysms of the aortic arch: a reassessment". The Annals of Thoracic Surgery. 53 (1): 109–14. doi:10.1016/0003-4975(92)90767-x. PMID 1530810.

[pmid24502618-8] Ramachandran S, Venugopal A, Kutty VR, A V, G D, Chitrasree V, Mullassari A, Pratapchandran NS, Santosh KR, Pillai MR, Kartha CC (7 February 2014). "Plasma level of cyclophilin A is increased in patients with type 2 diabetes mellitus and suggests presence of vascular disease". Cardiovascular Diabetology. 13: 38. doi:10.1186/1475-2840-13-38. PMC 3922405. PMID 24502618.

[pmid23180369-9] Wei Y, Jinchuan Y, Yi L, Jun W, Zhongqun W, Cuiping W (Jun 2013). "Antiapoptotic and proapoptotic signaling of cyclophilin A in endothelial cells". Inflammation. 36 (3): 567–72. doi:10.1007/s10753-012-9578-7. PMID 23180369. S2CID 24968009.

[pmid24713575-10] Hoffmann H, Schiene-Fischer C (Jul 2014). "Functional aspects of extracellular cyclophilins". Biological Chemistry. 395 (7–8): 721–35. doi:10.1515/hsz-2014-0125. PMID 24713575. S2CID 32395688.

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