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Pentosan polysulfate information


Pentosan polysulfate
Clinical data
Trade namesElmiron, Zycosan
Other namesPPS, (1->4)-β-Xylan 2,3-bis(hydrogen sulfate) with a 4 O-methyl-α-D-glucuronate
AHFS/Drugs.comMonograph
License data
  • US DailyMed: pentosan polysulfate
Routes of
administration		By mouth, intramuscular
ATC code
  • C05BA04 (WHO) G04BX15 (WHO), QC05BA04 (WHO), QG04BX15 (WHO) QM01AX90 (WHO)
Legal status
Legal status
  • US: ℞-only[1]
Pharmacokinetic data
ExcretionFeces, urine[1]
Identifiers
CAS Number
  • 37300-21-3 checkY
  • as sodium: 140207-93-8
PubChem CID
  • 37720
DrugBank
  • DB00686
ChemSpider
  • 34595 checkY
UNII
  • F59P8B75R4
  • as sodium: 914032762Y
KEGG
  • as sodium: D05428
ChEMBL
  • ChEMBL4073796
  • as sodium: ChEMBL1201516
CompTox Dashboard (EPA)
  • DTXSID10190764 Edit this at Wikidata
Chemical and physical data
FormulaC10H18O21S4
Molar mass602.47 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • O[C@@H]1CO[C@@H](O[C@@H]2CO[C@@H](O)[C@H](OS(O)(=O)=O)[C@H]2OS(O)(=O)=O)[C@H](OS(O)(=O)=O)[C@H]1OS(O)(=O)=O
InChI
  • InChI=1S/C10H18O21S4/c11-3-1-26-10(8(31-35(22,23)24)5(3)28-32(13,14)15)27-4-2-25-9(12)7(30-34(19,20)21)6(4)29-33(16,17)18/h3-12H,1-2H2,(H,13,14,15)(H,16,17,18)(H,19,20,21)(H,22,23,24)/t3-,4-,5+,6+,7-,8-,9-,10+/m1/s1
  • Key:FCCNSUIJIOOXEZ-SJYYZXOBSA-N
  (verify)

Pentosan polysulfate, sold under the brand name Elmiron among others, is a medication used for the treatment of interstitial cystitis.[1] It was approved for medical use in the United States in 1996.[1][2][3]

  1. ^ a b c d "Elmiron- pentosan polysulfate sodium capsule, gelatin coated". DailyMed. 10 November 2022. Retrieved 21 December 2022.
  2. ^ Lindeke-Myers A, Hanif AM, Jain N (2022). "Pentosan polysulfate maculopathy". Survey of Ophthalmology. 67 (1): 83–96. doi:10.1016/j.survophthal.2021.05.005. PMID 34000253. S2CID 234767956.
  3. ^ "Elmiron (pentosan polysulfate sodium)" (PDF). FDA approval letter. U.S. Food and Drug Administration. 25 September 1996.

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