In enzymology, a phosphoenolpyruvate mutase (EC 5.4.2.9) is an enzyme that catalyzes the chemical reaction
phosphoenolpyruvate 3-phosphonopyruvate
Hence, this enzyme has one substrate, phosphoenolpyruvate (PEP), and one product, 3-phosphonopyruvate (PPR), which are structural isomers.
This enzyme belongs to the family of isomerases, specifically the phosphotransferases (phosphomutases), which transfer phosphate groups within a molecule. The systematic name of this enzyme class is phosphoenolpyruvate 2,3-phosphonomutase. Other names in common use include phosphoenolpyruvate-phosphonopyruvate phosphomutase, PEP phosphomutase, phosphoenolpyruvate phosphomutase, PEPPM, and PEP phosphomutase. This enzyme participates in aminophosphonate metabolism.
Phosphoenolpyruvate mutase was discovered in 1988.[1][2]
^Bowman E, McQueney M, Barry RJ, Dunaway-Mariano D (1988). "Catalysis and thermodynamics of the phosphoenolpyruvate phosphonopyruvate rearrangement - entry into the phosphonate class of naturally-occurring organo-phosphorus compounds". J. Am. Chem. Soc. 110 (16): 5575–5576. doi:10.1021/ja00224a054.
^Seidel HM, Freeman S, Seto H, Knowles JR (1988). "Phosphonate biosynthesis: isolation of the enzyme responsible for the formation of a carbon-phosphorus bond". Nature. 335 (6189): 457–458. Bibcode:1988Natur.335..457S. doi:10.1038/335457a0. PMID 3138545. S2CID 4310660.
and 17 Related for: Phosphoenolpyruvate mutase information
In enzymology, a phosphoenolpyruvatemutase (EC 5.4.2.9) is an enzyme that catalyzes the chemical reaction phosphoenolpyruvate ⇌ {\displaystyle \rightleftharpoons...
carboxyphosphonate to 3-(hydrohydroxyphosphoryl) pyruvate carbon dioxide, and phosphoenolpyruvatemutase (EC 5.4.2.9), which is involved in the biosynthesis of phosphinothricin...
class are: This category (EC 5.4) includes intramolecular transferases (mutases). These isomerases catalyze the transfer of functional groups from one...
1UJQ, 1XG3, and 1XG4. The structure is very similar to that of phosphoenolpyruvatemutase. A homotetrameric biological unit is composed of beta barrels...
Seidel HM, Knowles JR (1994). "Interaction of inhibitors with phosphoenolpyruvatemutase: implications for the reaction mechanism and the nature of the...
carboxyphosphonate to 3-(hydrohydroxyphosphoryl) pyruvate carbon dioxide, and phosphoenolpyruvatemutase (EC 5.4.2.9), which is involved in the biosynthesis of phosphinothricin...
The elucidation of its structure was made nearly 50 years later. Phosphoenolpyruvate and erythrose-4-phosphate condense to form 3-deoxy-D-arabinohept...
is made from the precursor compounds erythrose-4-phosphate, and phosphoenolpyruvate. Shikimic acid is then converted to chorismic acid through various...
Benson, T.E.; Kim, D.H.; Lees, W.J. (1996). "The versatility of phosphoenolpyruvate and its vinyl ether products in biosynthesis". Chemistry & Biology...
mediated by a phenylalanine (PheA) or tyrosine (TyrA) specific chorismate mutase-prephenate dehydrogenase. PheA uses a simple dehydrogenase to convert prephenate...
reaction with one substrate and one product. Such cases exist: for example, a mutase such as phosphoglucomutase catalyses the transfer of a phospho group from...
undergoes intramolecular rearrangement, which is catalyzed by methylmalonyl-CoA mutase (requiring B12 as a coenzyme) to form succinyl-CoA. The succinyl-CoA formed...
C-terminal. It resembles the family of proteins that include phosphoglycerate mutases and acid phosphatases. The domain has a mixed α/ β structure, with a six-stranded...
1074/jbc.273.27.16962. PMID 9642259. Wohl, RC; Markus, G (1972). "Phosphoenolpyruvate carboxylase of Escherichia coli. Purification and some properties"...
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