Bis(oxazoline) ligands (often abbreviated BOX ligands) are a class of privileged chiral ligands containing two oxazoline rings. They are typically C2‑symmetric and exist in a wide variety of forms; with structures based around CH2 or pyridine linkers being particularly common (often generalised BOX and PyBOX respectively). The coordination complexes of bis(oxazoline) ligands are used in asymmetric catalysis. These ligands are examples of C2-symmetric ligands.
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development of very first bisoxazolines by Nishiyama et al., who synthesised the first PyBox ligands in 1989. These ligands were used in the hydrosilylation...
The use of P,N ligands in asymmetric hydrogenation can be traced to the C2 symmetric bisoxazolineligand. However, these symmetric ligands were soon superseded...
glyoxylate compound has been added to N,N-dimethylaniline with a chiral bisoxazolineligand–copper(II) triflate catalyst system also in a Friedel–Crafts hydroxyalkylation:...
cyclization was reported by Varinder Aggarwal and utilized copper (II) bisoxazolineligand complexes with up to 98% ee. The enantiomeric excess was unaffected...
by Jacobsen and Zhou, are introduced below. Most common chiral bisoxazoline (BOX) ligands consist of two identical chiral oxazoline moieties, substituted...
alkylammonium and sugar species, including examples of chiral recognition. Bisoxazolineligands (BOX) Phosphinooxazolines (PHOX) Trisoxazolinylborate Trispyrazolylborate...
oxazoline based ligands (S)-iPr-PHOX - A specific PHOX ligandBisoxazolines (BOX) Trisoxazolines (TRISOX) Structurally related ligands Trost ligand Diphenyl-2-pyridylphosphine...
"Linear Regression Model Development for Analysis of Asymmetric Copper-Bisoxazoline Catalysis". ACS Catalysis. 11 (7): 3916–3922. doi:10.1021/acscatal.1c00531...
diisocyanate for example. Depending on the linker, bisoxazolines can function as chelating ligands. Isoxazolidine, isomeric with oxazolidine. Isoxazoline...
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