Regulation of inorganic phosphate within the cellular system.
The Phosphate (Pho) regulon is a regulatory mechanism used for the conservation and management of inorganic phosphate within the cell. It was first discovered in Escherichia coli as an operating system for the bacterial strain, and was later identified in other species.[1] The Pho system is composed of various components including extracellular enzymes and transporters that are capable of phosphate assimilation in addition to extracting inorganic phosphate from organic sources.[2] This is an essential process since phosphate plays an important role in cellular membranes, genetic expression, and metabolism within the cell. Under low nutrient availability, the Pho regulon helps the cell survive and thrive despite a depletion of phosphate within the environment. When this occurs, phosphate starvation-inducible (psi) genes activate other proteins that aid in the transport of inorganic phosphate.[3]
^Wanner, B. L.; Chang, B. D. (December 1987). "The phoBR operon in Escherichia coli K-12". Journal of Bacteriology. 169 (12): 5569–5574. doi:10.1128/jb.169.12.5569-5574.1987. ISSN 0021-9193. PMC 213987. PMID 2824439.
^Santos-Beneit, Fernando (2015-04-30). "The Pho regulon: a huge regulatory network in bacteria". Frontiers in Microbiology. 6: 402. doi:10.3389/fmicb.2015.00402. ISSN 1664-302X. PMC 4415409. PMID 25983732.
^Vershinina, O. A.; Znamenskaya, L. V. (2002). "The Pho Regulons of Bacteria". Microbiology. 71 (5): 497–511. doi:10.1023/a:1020547616096. ISSN 0026-2617. PMID 12449623. S2CID 36152299.
The Phosphate (Pho) regulon is a regulatory mechanism used for the conservation and management of inorganic phosphate within the cell. It was first discovered...
collide with Earth Phoregulon, a bacterial phosphate regulatory mechanism Pho4, a basic helix-loop-helix transcription factor Phos, a genus of sea snails...
It has been shown in Pseudomonas aeruginosa that the phoU mutant (phoU belongs to the PhoRegulon) synthesizes more (p)ppGpp and this would be one of the...
Hoffer, Sally; Uden, Nathalie; Tommassen, Jan (2001). "Expression of the phoregulon interferes with induction of the uhpT gene in Escherichia coli K-12"...
Istanbul. She presented a paper entitled The Xanthomonas axonopodis citri PHOregulon. Most media relating to Taschner can be found on the IQC website. In...
expression: evidence for multiple positive regulators of the phosphate regulon in Escherichia coli". Genetics. 96 (2): 353–66. doi:10.1093/genetics/96...
multidrug efflux pump of the RND superfamily (TC #2.A.6.2)) and the mar regulon itself, and (3) MarB, a small protein of 71 amino acyl residues of unknown...
Torsten; Bulitta, Jürgen B. (May 2018). "Determination of the small RNA GcvB regulon in the Gram-negative bacterial pathogen Pasteurella multocida and identification...
may be to compensate for the inactivation of the CorA protein by the PhoPQ regulon. The authors suggest that the CorA protein is inactivated to allow the...
Dersch P (Apr 2, 2014). "A direct link between the global regulator PhoP and the Csr regulon in Y. pseudotuberculosis through the small regulatory RNA CsrC"...
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