Global InformationGuanosine pentaphosphate information
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| Other names
guanosine pentaphosphate (pppGpp), guanosine tetraphosphate (ppGpp)
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| Identifiers | |
CAS Number
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PubChem CID
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| Properties | |
Chemical formula
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C10H18N5O20P5 |
| Molar mass | 683.14 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
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(p)ppGpp, guanosine pentaphosphate and tetraphosphate, also known as the "magic spot" nucleotides,[1] are alarmones involved in the stringent response in bacteria that cause the inhibition of RNA synthesis when there is a shortage of amino acids. This inhibition by (p)ppGpp decreases translation in the cell, conserving amino acids present. Furthermore, ppGpp and pppGpp cause the up-regulation of many other genes involved in stress response such as the genes for amino acid uptake (from surrounding media) and biosynthesis.[2]
- ^ Adams, D.G.; Phillips, D.O.; Nichols, Josie M.; Carr, N.G. (1977-09-01). "The presence and absence of magic spot nucleotide modulation in cyanobacteria undergoing nutritional shift-down". FEBS Letters. 81 (1): 48–52. doi:10.1016/0014-5793(77)80925-3. PMID 409622. S2CID 12110840.
- ^ Srivatsan, A.; Wang, J. D. (2008). "Control of bacterial transcription, translation and replication by (p)ppGpp". Current Opinion in Microbiology. 11 (2): 100–105. doi:10.1016/j.mib.2008.02.001. PMID 18359660.