Structure of AhpC, a bacterial 2-cysteine peroxiredoxin from Salmonella typhimurium.
Identifiers
Symbol
AhpC-TSA
Pfam
PF00578
Pfam clan
CL0172
InterPro
IPR000866
SCOP2
1prx / SCOPe / SUPFAM
OPM superfamily
131
OPM protein
1xvw
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
peroxiredoxin
Identifiers
EC no.
1.11.1.15
CAS no.
207137-51-7
Databases
IntEnz
IntEnz view
BRENDA
BRENDA entry
ExPASy
NiceZyme view
KEGG
KEGG entry
MetaCyc
metabolic pathway
PRIAM
profile
PDB structures
RCSB PDB PDBe PDBsum
Gene Ontology
AmiGO / QuickGO
Search
PMC
articles
PubMed
articles
NCBI
proteins
Peroxiredoxins (Prxs, EC 1.11.1.15; HGNC root symbol PRDX) are a ubiquitous family of antioxidant enzymes that also control cytokine-induced peroxide levels and thereby mediate signal transduction in mammalian cells. The family members in humans are PRDX1, PRDX2, PRDX3, PRDX4, PRDX5, and PRDX6. The physiological importance of peroxiredoxins is indicated by their relative abundance (one of the most abundant proteins in erythrocytes after hemoglobin is peroxiredoxin 2). Their function is the reduction of peroxides, specifically hydrogen peroxide, alkyl hydroperoxides, and peroxynitrite.[1]
^Rhee, Sue Goo; Kil, In Sup (2017). "Multiple Functions and Regulation of Mammalian Peroxiredoxins". Annual Review of Biochemistry. 86: 749–775. doi:10.1146/annurev-biochem-060815-014431. PMID 28226215.
Peroxiredoxins (Prxs, EC 1.11.1.15; HGNC root symbol PRDX) are a ubiquitous family of antioxidant enzymes that also control cytokine-induced peroxide levels...
Peroxiredoxin-1 is a protein that in humans is encoded by the PRDX1 gene. This gene encodes a member of the peroxiredoxin family of antioxidant enzymes...
three classes: typical 2-cysteine peroxiredoxins; atypical 2-cysteine peroxiredoxins; and 1-cysteine peroxiredoxins. These enzymes share the same basic...
Peroxiredoxin-2 is a protein that in humans is encoded by the PRDX2 gene. PRDX2 encodes a member of the peroxiredoxin family of antioxidant enzymes, which...
PeroxiRedoxin classification indEX (PREX) is a database of peroxiredoxins (Prxs) classified into one of six distinct subfamilies. Classification relies...
the chemical reaction peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH ⇌ {\displaystyle \rightleftharpoons } peroxiredoxin-(S-hydroxycysteine) +...
Peroxiredoxin-5 (PRDX5), mitochondrial is a protein that in humans is encoded by the PRDX5 gene, located on chromosome 11. This gene encodes a member...
reductase, glutathione reductase, glutaredoxin, glutathione peroxidase, and peroxiredoxin. They are involved in various processes, such as sulfur metabolism,...
catalytic activity of different proteins (e.g. metastasis suppressor NME1, peroxiredoxin 5, GAPDH, among others) is reported. To restore the protein's activity...
that in humans is encoded by the PRDX3 gene. It is a member of the peroxiredoxin family of antioxidant enzymes. This gene encodes a protein with antioxidant...
Peroxiredoxin-6 is a protein that in humans is encoded by the PRDX6 gene. It is a member of the peroxiredoxin family of antioxidant enzymes. The protein...
system to distinguish the individual members. For example, for the peroxiredoxin family, PRDX is the root symbol, and the family members are PRDX1, PRDX2...
bacteria, archaea, and eukaryotes as selenocysteine, where selenoprotein peroxiredoxins protect bacterial and eukaryotic cells against oxidative damage. Selenoprotein...
roseofulvus. Frenolicin B is a selective inhibitor of glutaredoxin 3 and peroxiredoxin 1. "Frenolicin B". Pubchem.ncbi.NLM.nih.gov. Bycroft, Barrie W.; Payne...
Green EW, Zhao Y, van Ooijen G, Olmedo M, Qin X, et al. (May 2012). "Peroxiredoxins are conserved markers of circadian rhythms". Nature. 485 (7399): 459–464...
~88 kcal/mol for the (valence) isoelectronic hydroperoxides, ROOH. Peroxiredoxins are ubiquitous and abundant enzymes that detoxify peroxides. They function...
ISBN 978-0-12-540047-3. PMID 8016325. Akerman SE, Müller S (August 2003). "2-Cys peroxiredoxin PfTrx-Px1 is involved in the antioxidant defence of Plasmodium falciparum"...
the SRPX gene. Bioinformatics analysis suggests the SRPX protein is a peroxiredoxin. GRCh38: Ensembl release 89: ENSG00000101955 – Ensembl, May 2017 GRCm38:...
parasite Plasmodium falciparum by inhibition of the human host enzyme peroxiredoxin 6. The authors present data that the original target of Darapladib,...
Cambridge. This group discovered circadian rhythms in redox proteins (peroxiredoxins) in cells that lacked a nucleus – human red blood cells. In these cells...
reductase. Antioxidant enzymes, such as glutathione peroxidases and peroxiredoxins, generate glutathione disulfide during the reduction of peroxides such...
CCDC80 gene. Bioinformatics analysis suggests the CCDC80 protein is a peroxiredoxin. GRCh38: Ensembl release 89: ENSG00000091986 – Ensembl, May 2017 GRCm38:...
carrying reactive electrons from the peroxide to the glutathione. Peroxiredoxins also degrade H2O2, within the mitochondria, cytosol, and nucleus. 2...
symbol" as the root for the various gene symbols. For example, for the peroxiredoxin family, PRDX is the root symbol, and the family members are PRDX1, PRDX2...
toxins that have been confirmed to be within the venom are cystatins, peroxiredoxin and galectin. Galectin induces cell death in its victims and cystatins...
PRMT6: Protein arginine methyltransferase 6 PRXL2B: encoding protein Peroxiredoxin like 2B PSRC1: Proline/serine-rich coiled-coil protein 1 RAD54L: RAD54-like...
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