Penetration enhancers (also called chemical penetration enhancers, absorption enhancers or sorption promotors) are chemical compounds that can facilitate the penetration of active pharmaceutical ingredients (API) into or through the poorly permeable biological membranes. These compounds are used in some pharmaceutical formulations to enhance the penetration of APIs in transdermal drug delivery and transmucosal drug delivery (for example, ocular, nasal, oral and buccal).[1] They typically penetrate into the biological membranes and reversibly decrease their barrier properties.
^Maher, Sam; Casettari, Luca; Illum, Lisbeth (July 2019). "Transmucosal Absorption Enhancers in the Drug Delivery Field". Pharmaceutics. 11 (7): 339. doi:10.3390/pharmaceutics11070339. ISSN 1999-4923. PMC 6680553. PMID 31311173.
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Penetrationenhancers (also called chemical penetrationenhancers, absorption enhancers or sorption promotors) are chemical compounds that can facilitate...
is also demonstrated to enhance the percutaneous absorption of certain molecules and has found use as a penetrationenhancer: an agent used in topical...
Dobner, B. and Neubert, R. (2012). Study of the influence of the penetrationenhancer isopropyl myristate on the nanostructure of stratum corneum lipid...
exploration have been chemical and physical penetration-enhancing mechanisms. A brief overview of physical penetration methods are summarized in the table below...
agents, stabilizers, dispersing agents, penetrationenhancers, buffers and preservatives. Penetrationenhancers are excipients that can increase skin permeability...
permeability through the cornea could be facilitated with addition of penetrationenhancers into topical formulations. If the corneal stroma develops visually...
compounds act as active substance carriers. They also serve as skin penetrationenhancers and consistency or viscosity modifiers. The oily excipients may...
e.g.: Tiger Balm, or IcyHot patches or knee/elbow sleeves. As a penetrationenhancer in transdermal drug delivery. In decongestants for chest and sinuses...
lotions where it acts as an emollient, moisturizer, anti-oxidant, penetrationenhancer, occlusive skin conditioner, and anti-bacterial agent. For treatment...
rhythm and pace of vaginal stimulation and the extent and duration of penetration and because of its ability to adequately stimulate the clitoris. There...
patches Backing - Protects the patch from the outer environment Penetrationenhancer - These are permeation promoters for drugs, which increase delivery...
and the mucosa, the tablet should contain: mucoadhesive agents, penetrationenhancers, enzyme inhibitors and solubility modifiers. The mucoadhesive agents...
activity, but is also used by same-sex couples. It may involve sexual penetration or non-penetrative sex (for example, intercrural sex), and its penile-vaginal...
the skin delivery of various drugs. Ethanol is an efficient permeation enhancer that is believed to act by affecting the intercellular region of the stratum...
The social penetration theory (SPT) proposes that as relationships develop, interpersonal communication moves from relatively shallow, non-intimate levels...
coefficient in the stratum corneum. Tranexamic acid can be combined with penetrationenhancers and microneedling to overcome this limitation. Cosmetic uses may...
Dhawan S, Shama A (2010). "Carriers/vesicles based approaches for penetrationenhancement in transdermal drug delivery". Latest Review. 8 (1): 1–5. US 4830857...
sex toy, often explicitly phallic in appearance, intended for sexual penetration or other sexual activity during masturbation or with sex partners. Dildos...
in medicine. The Ghandehari lab found that the use of Capmul, a penetrationenhancer recognized as Generally Regarded as Safe by the FDA, with D-NAC,...