Pathogenomics is a field which uses high-throughput screening technology and bioinformatics to study encoded microbe resistance, as well as virulence factors (VFs), which enable a microorganism to infect a host and possibly cause disease.[1][2][3][4] This includes studying genomes of pathogens which cannot be cultured outside of a host.[5] In the past, researchers and medical professionals found it difficult to study and understand pathogenic traits of infectious organisms.[6] With newer technology, pathogen genomes can be identified and sequenced in a much shorter time and at a lower cost,[7][8] thus improving the ability to diagnose, treat, and even predict and prevent pathogenic infections and disease.[9] It has also allowed researchers to better understand genome evolution events - gene loss, gain, duplication, rearrangement - and how those events impact pathogen resistance and ability to cause disease.[8] This influx of information has created a need for bioinformatics tools and databases to analyze and make the vast amounts of data accessible to researchers,[10][11] and it has raised ethical questions about the wisdom of reconstructing previously extinct and deadly pathogens in order to better understand virulence.[12]
^Sharma AK, Dhasmana N, Dubey N, Kumar N, Gangwal A, Gupta M, Singh Y (March 2017). "Bacterial Virulence Factors: Secreted for Survival". Indian Journal of Microbiology. 57 (1): 1–10. doi:10.1007/s12088-016-0625-1. PMC 5243249. PMID 28148975.
^"How Pathogens Cause Disease | Microbiology". courses.lumenlearning.com. Retrieved 4 November 2019.
^Yang J, Chen L, Sun L, Yu J, Jin Q (January 2008). "VFDB 2008 release: an enhanced web-based resource for comparative pathogenomics". Nucleic Acids Research. 36 (Database issue): D539-42. doi:10.1093/nar/gkm951. PMC 2238871. PMID 17984080.
^Threats, Institute of Medicine (US) Forum on Microbial (2013). Workshop Overview. National Academies Press (US). Retrieved 8 November 2019.
^Ekundayo TC, Okoh AI (2018). "Plesiomonas shigelloides That Were Deemed Inconclusive by Traditional Experimental Approaches". Frontiers in Microbiology. 9: 3077. doi:10.3389/fmicb.2018.03077. PMC 6309461. PMID 30627119.
^Threats, Institute of Medicine (US) Forum on Microbial (2013). Workshop Overview. National Academies Press (US). Retrieved 8 November 2019.
^ abLynch T, Petkau A, Knox N, Graham M, Van Domselaar G (October 2016). "A Primer on Infectious Disease Bacterial Genomics". Clinical Microbiology Reviews. 29 (4): 881–913. doi:10.1128/CMR.00001-16. PMC 5010755. PMID 28590251.
^Demuth A, Aharonowitz Y, Bachmann TT, Blum-Oehler G, Buchrieser C, Covacci A, et al. (May 2008). "Pathogenomics: an updated European Research Agenda". Infection, Genetics and Evolution. 8 (3): 386–93. doi:10.1016/j.meegid.2008.01.005. hdl:10033/30395. PMID 18321793.
^Amoutzias, Grigorios D.; Nikolaidis, Marios; Hesketh, Andrew (17 May 2022). "The Notable Achievements and the Prospects of Bacterial Pathogen Genomics". Microorganisms. 10 (5): 1040. doi:10.3390/microorganisms10051040. ISSN 2076-2607. PMC 9148168. PMID 35630482.
^Vinatzer BA, Heath LS, Almohri HM, Stulberg MJ, Lowe C, Li S (15 May 2019). "Cyberbiosecurity Challenges of Pathogen Genome Databases". Frontiers in Bioengineering and Biotechnology. 7: 106. doi:10.3389/fbioe.2019.00106. PMC 6529814. PMID 31157218.
Pathogenomics is a field which uses high-throughput screening technology and bioinformatics to study encoded microbe resistance, as well as virulence...
genetic testing, clinical chemistry tests, molecular diagnostics and pathogenomics have made a huge impact on diagnostic capability. In 1761 the percussion...
Kumar N, et al. (November 2012). "Genome sequence and comparative pathogenomics analysis of a Salmonella enterica Serovar Typhi strain associated with...
ecological communities and their interactions with the environment. 34. Pathogenomics**: Study of the genomes of pathogens to understand their biology and...
Sexually Transmitted Infections". In Singh S (ed.). Diagnostics to Pathogenomics of Sexually Transmitted Infections. Wiley. pp. 28–34. ISBN 978-1-119-38084-9...
response". International Journal of Medical Microbiology. Special issue: Pathogenomics. 297 (7–8): 577–587. doi:10.1016/j.ijmm.2007.03.009. PMID 17467337....
complexity of successive bacterial epidemics deconvoluted by comparative pathogenomics". Proceedings of the National Academy of Sciences. 107 (9): 4371–76...
disease) Molecular pathology Laboratory Developed Test Pathogenesis Pathogenomics Pathology Precision medicine Personalized medicine Poste G (May 2001)...
Fifteenth IOCV Conference, 2002- Citrus Tristeza Virus. Xiong, Z. "Pathogenomics of Citrus Tristeza Virus." Ag.arizona.edu. University of Arizona. Web...
Kumar N, et al. (November 2012). "Genome sequence and comparative pathogenomics analysis of a Salmonella enterica Serovar Typhi strain associated with...
epidemic outbreak of wheat blast in Bangladesh in 2016 using field pathogenomics, open data sharing and open science. Since then he has been leading...
dispersal of pathogens at an international scale. She developed "field pathogenomics", a surveillance technique that can analyse diversity in pathogen populations...
EM, Raikhel AS, Christensen BM, Dimopoulos G, Muskavitch MA (2010). "Pathogenomics of Culex quinquefasciatus and meta-analysis of infection responses to...
different microbial challenges. Felix M. Key heads the "Evolutionary Pathogenomics" research group, which aims to uncover the genetic mechanisms and phenotypic...
also from Makerere in 2013. He later obtained a joint PhD degree in Pathogenomics from Makerere and Yale University in 2018. He his a fellow of Human...
pathogens presence in a population. Viruses portal Epidemiology and sewage Pathogenomics Sommers P, Chatterjee A, Varsani A, Trubl G (September 2021). "Integrating...
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