Paromomycin is an antimicrobial used to treat a number of parasitic infections including amebiasis, giardiasis, leishmaniasis, and tapeworm infection.[3] It is a first-line treatment for amebiasis or giardiasis during pregnancy.[3] Otherwise, it is generally a second line treatment option.[3] It is taken by mouth, applied to the skin, or by injection into a muscle.[3]
Common side effects when taken by mouth include loss of appetite, vomiting, abdominal pain, and diarrhea.[3] When applied to the skin side effects include itchiness, redness, and blisters.[3] When given by injection there may be fever, liver problems, or hearing loss.[3] Use during breastfeeding appears to be safe.[4] Paromomycin is in the aminoglycoside family of medications and causes microbe death by stopping the creation of bacterial proteins.[3]
Paromomycin was discovered in the 1950s from a type of streptomyces and came into medical use in 1960.[1][4] It is on the World Health Organization's List of Essential Medicines.[5][6] Paromomycin is available as a generic medication.[7]
^ ab"Paromomycin". Pharmaceutical Manufacturing Encyclopedia (3rd ed.). Elsevier. 2013. p. 21p. ISBN 978-0-8155-1856-3. Archived from the original on 20 December 2016.
^Cite error: The named reference Neal1994 was invoked but never defined (see the help page).
^ abcdefghi"Paromomycin Sulfate". The American Society of Health-System Pharmacists. Archived from the original on 17 November 2016. Retrieved 3 December 2016.
^ abDavidson RN, den Boer M, Ritmeijer K (July 2009). "Paromomycin". Transactions of the Royal Society of Tropical Medicine and Hygiene. 103 (7): 653–660. doi:10.1016/j.trstmh.2008.09.008. PMID 18947845.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
^Hamilton R (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 54. ISBN 978-1-284-05756-0.
Paromomycin is an antimicrobial used to treat a number of parasitic infections including amebiasis, giardiasis, leishmaniasis, and tapeworm infection...
combination of pentavalent antimonials and paromomycin, and miltefosine. For cutaneous disease, paromomycin, fluconazole, or pentamidine may be effective...
amoeba cysts, usually this treatment is followed by an agent (such as paromomycin or diloxanide furoate) that acts on the organism in the lumen. In addition...
7-day course as well as a 3- or 7-day course of intravenous MA with paromomycin + 12% methylbenzethonium chloride. For L. braziliensis, oral pentoxifylline...
where infections are not common, it is a second line treatment after paromomycin when a person has no symptoms. For people who are symptomatic, it is...
intestinal infections, the most effective of which has been shown to be Paromomycin (also known as Humatin). E. histolytica infections occur in both the...
often treated with two antimicrobial drugs such as metronidazole and paromomycin or iodoquinol. With correct treatment, most cases of amoebic and bacterial...
increased monitoring is recommended. The aminoglycosides neomycin and paromomycin have been found to reduce gastrointestinal (GI) absorption of methotrexate...
efficacy in severely immunocompromised patients. Certain agents such as paromomycin and azithromycin are sometimes used as well, but they only have partial...
including quinacrine, nitazoxanide, bacitracin zinc, furazolidone and paromomycin. Mepacrine may also be used for refractory cases. Probiotics, when given...
counterparts. No proven cure exists for C. serpentis, but some drugs, such as Paromomycin, have proven promising results in the treatment of captive King cobras...
antibiotic paromomycin for use in treating VL; its antileishmanial properties were first identified in the 1980s. A treatment with paromomycin costs about...
species from the genus of Streptomyces. Streptomyces catenulae produces paromomycin, catenulin, N-isobutyrylpepstatin neomycin E, neomycin F, 2-amini-3-butynoic...
rash. There are other medications that treat dientamoebiasis, including paromomycin and metronidazole. Tetracycline and doxycycline have also been used as...
in some pharmaceutical agents, including the antibiotics neomycin and paromomycin. Ribose as its 5-phosphate ester is typically produced from glucose by...
cutaneous, visceral, and mucosal types. Some combination of miltefosine, paromomycin and liposomal amphotericin B, however, may be recommended due to issues...
approved for the treatment of cryptosporidiosis in immunocompetent hosts. Paromomycin may alleviate some of the diarrhoeal symptoms and is registered for it...
oxytetracycline and tetracycline are produced in cultures of S. rimosus. Paromomycin has also been isolated from cultures of S. rimosus. Streptomyces rimosus's...
endemic countries.[citation needed] SSG&PM, a sodium stibogluconate plus paromomycin combination therapy, is a shorter-course, cost-efficient treatment option...
antimonials. In Africa, a combination of pentavalent antimonials and paromomycin is recommended. These, however, can have significant side effects. Miltefosine...
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