PTPRT information

PTPRT
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2OOQ
Identifiers
Aliases	PTPRT, RPTPrho, protein tyrosine phosphatase, receptor type T, protein tyrosine phosphatase receptor type T, RPTP-rho, R-PTP-T
External IDs	OMIM: 608712 MGI: 1321152 HomoloGene: 56924 GeneCards: PTPRT
Gene location (Human)
Chr.	Chromosome 20 (human)
End	43,189,970 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	162,503,067 bp
RNA expression pattern
	Top expressed in
	Brodmann area 10; ; middle temporal gyrus; ; Brodmann area 23; ; frontal pole; ; superior frontal gyrus; ; Brodmann area 46; ; orbitofrontal cortex; ; postcentral gyrus; ; dorsolateral prefrontal cortex; ; bronchial epithelial cell;
	Top expressed in
	piriform cortex; ; superior frontal gyrus; ; superior colliculus; ; olfactory bulb; ; dorsal tegmental nucleus; ; median eminence; ; medial vestibular nucleus; ; dorsomedial hypothalamic nucleus; ; paraventricular nucleus of hypothalamus; ; primary motor cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein tyrosine phosphatase activity; phosphatase activity; beta-catenin binding; protein binding; phosphoprotein phosphatase activity; hydrolase activity; alpha-catenin binding; cadherin binding; delta-catenin binding; gamma-catenin binding; transmembrane receptor protein tyrosine phosphatase activity; protein phosphatase binding; protein homodimerization activity; STAT family protein binding;
Cellular component	integral component of membrane; cell surface; plasma membrane; membrane; integral component of plasma membrane;
Biological process	protein dephosphorylation; cell adhesion; signal transduction; homophilic cell adhesion via plasma membrane adhesion molecules; transmembrane receptor protein tyrosine kinase signaling pathway; dephosphorylation; peptidyl-tyrosine dephosphorylation; negative regulation of cell migration; cellular response to interleukin-6; negative regulation of receptor signaling pathway via STAT; peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	11122
	19281
	ENSG00000196090
	ENSMUSG00000053141
	O14522
	Q99M80
	NM_007050; NM_133170; NM_001394024; NM_001394025; NM_001394026
	NM_001291149; NM_001291150; NM_001291151; NM_021464
	NP_008981; NP_573400
	NP_001278078; NP_001278079; NP_001278080; NP_067439
	Wikidata
View/Edit Human	View/Edit Mouse

Receptor-type tyrosine-protein phosphatase T is an enzyme that in humans is encoded by the PTPRT gene.^[5]^[6]^[7]

PTPRT is also known as PTPrho, PTPρ and human accelerated region 9. The human accelerated regions are 49 regions of the human genome that are conserved among vertebrates, but in humans show significant distinction from other vertebrates. This region may, therefore, have played a key role in differentiating humans from apes.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000196090 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000053141 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ McAndrew PE, Frostholm A, Evans JE, Zdilar D, Goldowitz D, Chiu IM, Burghes AH, Rotter A (Mar 1998). "Novel receptor protein tyrosine phosphatase (RPTPrho) and acidic fibroblast growth factor (FGF-1) transcripts delineate a rostrocaudal boundary in the granule cell layer of the murine cerebellar cortex". J Comp Neurol. 391 (4): 444–55. doi:10.1002/(SICI)1096-9861(19980222)391:4<444::AID-CNE3>3.0.CO;2-0. PMID 9486824. S2CID 20139070.
^ McAndrew PE, Frostholm A, White RA, Rotter A, Burghes AH (Jan 1999). "Identification and characterization of RPTP rho, a novel RPTP mu/kappa-like receptor protein tyrosine phosphatase whose expression is restricted to the central nervous system". Brain Res Mol Brain Res. 56 (1–2): 9–21. doi:10.1016/S0169-328X(98)00014-X. PMID 9602027.
^ "Entrez Gene: PTPRT protein tyrosine phosphatase, receptor type, T".
^ Pollard KS, Salama SR, Lambert N, Lambot MA, Coppens S, Pedersen JS, Katzman S, King B, Onodera C, Siepel A, Kern AD, Dehay C, Igel H, Ares M, Vanderhaeghen P, Haussler D (September 2006). "An RNA gene expressed during cortical development evolved rapidly in humans" (PDF). Nature. 443 (7108): 167–72. Bibcode:2006Natur.443..167P. doi:10.1038/nature05113. PMID 16915236. S2CID 18107797. supplement

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000196090 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000053141 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9486824-5] McAndrew PE, Frostholm A, Evans JE, Zdilar D, Goldowitz D, Chiu IM, Burghes AH, Rotter A (Mar 1998). "Novel receptor protein tyrosine phosphatase (RPTPrho) and acidic fibroblast growth factor (FGF-1) transcripts delineate a rostrocaudal boundary in the granule cell layer of the murine cerebellar cortex". J Comp Neurol. 391 (4): 444–55. doi:10.1002/(SICI)1096-9861(19980222)391:4<444::AID-CNE3>3.0.CO;2-0. PMID 9486824. S2CID 20139070.

[pmid9602027-6] McAndrew PE, Frostholm A, White RA, Rotter A, Burghes AH (Jan 1999). "Identification and characterization of RPTP rho, a novel RPTP mu/kappa-like receptor protein tyrosine phosphatase whose expression is restricted to the central nervous system". Brain Res Mol Brain Res. 56 (1–2): 9–21. doi:10.1016/S0169-328X(98)00014-X. PMID 9602027.

[entrez-7] "Entrez Gene: PTPRT protein tyrosine phosphatase, receptor type, T".

[Pollard2006-8] Pollard KS, Salama SR, Lambert N, Lambot MA, Coppens S, Pedersen JS, Katzman S, King B, Onodera C, Siepel A, Kern AD, Dehay C, Igel H, Ares M, Vanderhaeghen P, Haussler D (September 2006). "An RNA gene expressed during cortical development evolved rapidly in humans" (PDF). Nature. 443 (7108): 167–72. Bibcode:2006Natur.443..167P. doi:10.1038/nature05113. PMID 16915236. S2CID 18107797. supplement

PTPRT information

and 10 Related for: PTPRT information

PTPRT

List of distinct cell types in the adult human body

MAM domain

Human accelerated regions

FYN

Oncogenomics

Receptor tyrosine phosphatase

Fibronectin type III domain

Plakoglobin

PTPRU