positive regulation of protein export from nucleus
mitotic nuclear membrane disassembly
skeletal muscle cell differentiation
mitotic nuclear membrane reassembly
negative regulation of fibroblast proliferation
negative regulation of canonical Wnt signaling pathway
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
2010
13726
Ensembl
ENSG00000102119
ENSMUSG00000001964
UniProt
P50402
O08579
RefSeq (mRNA)
NM_000117
NM_007927
RefSeq (protein)
NP_000108
NP_031953
Location (UCSC)
Chr X: 154.38 – 154.38 Mb
Chr X: 73.3 – 73.31 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Emerin is a protein that in humans is encoded by the EMD gene, also known as the STA gene. Emerin, together with LEMD3, is a LEM domain-containing integral protein of the inner nuclear membrane in vertebrates. Emerin is highly expressed in cardiac and skeletal muscle. In cardiac muscle, emerin localizes to adherens junctions within intercalated discs where it appears to function in mechanotransduction of cellular strain and in beta-catenin signaling. Mutations in emerin cause X-linked recessive Emery–Dreifuss muscular dystrophy, cardiac conduction abnormalities and dilated cardiomyopathy.
It is named after Alan Emery.[5]
^ abcGRCh38: Ensembl release 89: ENSG00000102119 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000001964 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Peter Harper, Lois Reynolds, Tilli Tansey, eds. (2010). Clinical Genetics in Britain: Origins and development. Wellcome Witnesses to Contemporary Medicine. History of Modern Biomedicine Research Group. pp. 118–119. ISBN 978-0-85484-127-1. Wikidata Q29581774.
Emerin is a protein that in humans is encoded by the EMD gene, also known as the STA gene. Emerin, together with LEMD3, is a LEM domain-containing integral...
most important are lamina associated polypeptides 1 and 2 (LAP1, LAP2), emerin, lamin B-receptor (LBR), otefin and MAN1. Due to their positioning within...
States, a German pharmaceutical company Electrolytic manganese dioxide Emerin Empirical mode decomposition Equilibrium mode distribution ReadyBoost, disk-caching...
nuclear lamina. Lamins found on the cytosolic face of the membrane, such as emerin and nesprin, bind to the cytoskeleton to provide structural support. Lamins...
nuclear envelope protein emerin appears to be crucial in muscle cells, with certain mutations in lamin mimicking mutations in emerin and causing Emery–Dreifuss...
Both Emery–Dreifuss muscular dystrophy and its defective protein product, emerin, are named after him (the former jointly with Fritz E. Dreifuss)). Peter...
in Brazil German Adapted Birnbaum Pereira Diemer Dimer or Timer Emmerich Emerin Frazen França Goedems Goettems Greis Krais Hahn Hánn Herzenritter Heizeriter...
lamina-associated polypeptide 1 (LAP1), lamina-associated polypeptide-2 (LAP2), emerin and MAN1. Several integral nuclear membrane proteins of different size and...
in Turkey. It has been reported to produce an austocystin, deflectins, emerin, and a shamixanthone. A. turkensis has been cultivated on both Czapek yeast...
lamina. It also associates with the LEM Domain containing proteins LAP2, Emerin, and MAN1. The protein's DNA binding ability is modulated by ATP concentration...
K, Lamm AT, Feinstein N, Haithcock E, Wilson KL, Liu J, Gruenbaum Y. Ce-emerin and LEM-2: essential roles in Caenorhabditis elegans development, muscle...
PMC 3412960. PMID 22448045. Holaska JM, Kowalski AK, Wilson KL (Sep 2004). "Emerin caps the pointed end of actin filaments: evidence for an actin cortical...
merges with the Colihuno River (see above) to form the Caraulun River. Emerin River: rises in western Manufahi municipality on the northern outskirts...
Siçilsë Fusha e Arbreshëvet, pa drejtesi e thirrë edhè e përnjohur nën emërin i pa drejtë Piana dei Greci. Gjografikët e shkrimtarët të shekulit XVIII...
protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane. However, the localization of TMEM43 in myocardial...
et al. (2005). "Nesprin-2 is a multi-isomeric protein that binds lamin and emerin at the nuclear envelope and forms a subcellular network in skeletal muscle"...
different isoforms have been identified. PSME1 has been shown to interact with: Emerin and PSME2. ENSG00000284916 GRCh38: Ensembl release 89: ENSG00000092010,...
1038/nature02055. PMID 14574404. Haraguchi T, Holaska JM, Yamane M, et al. (2004). "Emerin binding to Btf, a death-promoting transcriptional repressor, is disrupted...
YTHDC1 has been shown to interact with: Abl gene, C-src tyrosine kinase, Emerin, KHDRBS1. and Metadherin Alternative splicing is altered in a number of...
Rais-Bahrami S, Wilson KL (2007). "Lmo7 is an emerin-binding protein that regulates the transcription of emerin and many other muscle-relevant genes". Hum...
muscle actin found in enteric tissues. ACTG2 has been shown to interact with Emerin. GRCh38: Ensembl release 89: ENSG00000163017 – Ensembl, May 2017 GRCm38:...
Lamina-associated polypeptide-1 interacts with the muscular dystrophy protein emerin and is essential for skeletal muscle maintenance. Dev Cell. 26:591-603....
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