PRDM16 information

PRDM16
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2N1I
Identifiers
Aliases	PRDM16, CMD1LL, LVNC8, MEL1, PFM13, PR domain 16, PR/SET domain 16, KMT8F
External IDs	OMIM: 605557; MGI: 1917923; HomoloGene: 11139; GeneCards: PRDM16; OMA:PRDM16 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	3,438,621 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	154,721,330 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; retinal pigment epithelium; ; ascending aorta; ; Descending thoracic aorta; ; ventricular zone; ; popliteal artery; ; tibial arteries; ; right coronary artery; ; pancreatic epithelial cell; ; left coronary artery;
	Top expressed in
	hand; ; retinal pigment epithelium; ; ascending aorta; ; Epithelium of choroid plexus; ; aortic valve; ; Rostral migratory stream; ; lateral septal nucleus; ; ciliary body; ; epithelium of stomach; ; lumbar subsegment of spinal cord;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; metal ion binding; sequence-specific DNA binding; SMAD binding; transcription coactivator activity; DNA binding; nucleic acid binding; histone-lysine N-methyltransferase activity; DNA-binding transcription factor activity, RNA polymerase II-specific; histone methyltransferase activity (H3-K9 specific); methyltransferase activity; transferase activity;
Cellular component	transcription repressor complex; nucleus; nucleoplasm; cytosol; aggresome; cytoplasm;
Biological process	positive regulation of brown fat cell differentiation; tongue development; transcription, DNA-templated; regulation of cellular respiration; somatic stem cell population maintenance; neurogenesis; stem cell population maintenance; negative regulation of transcription by RNA polymerase II; white fat cell differentiation; roof of mouth development; negative regulation of transforming growth factor beta receptor signaling pathway; brown fat cell differentiation; regulation of transcription, DNA-templated; cell differentiation; negative regulation of granulocyte differentiation; positive regulation of transcription, DNA-templated; negative regulation of transcription, DNA-templated; histone lysine methylation; positive regulation of cold-induced thermogenesis; histone H3-K9 methylation; heterochromatin organization; methylation;
	Sources:Amigo / QuickGO
Orthologs
	63976
	70673
	ENSG00000142611
	ENSMUSG00000039410
	Q9HAZ2
	A2A935
	NM_022114; NM_199454
	NM_001177995; NM_001291026; NM_001291029; NM_027504
	NP_071397; NP_955533
	NP_001171466; NP_001277955; NP_001277958; NP_081780
	Wikidata
View/Edit Human	View/Edit Mouse

PR domain containing 16, also known as PRDM16, is a protein which in humans is encoded by the PRDM16 gene.^[5]^[6]

PRDM16 acts as a transcription coregulator that controls the development of brown adipocytes in brown adipose tissue.^[7] Previously, this coregulator was believed to be present only in brown adipose tissue, but more recent studies have shown that PRDM16 is highly expressed in subcutaneous white adipose tissue as well.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000142611 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039410 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mochizuki N, Shimizu S, Nagasawa T, Tanaka H, Taniwaki M, Yokota J, Morishita K (November 2000). "A novel gene, MEL1, mapped to 1p36.3 is highly homologous to the MDS1/EVI1 gene and is transcriptionally activated in t(1;3)(p36;q21)-positive leukemia cells". Blood. 96 (9): 3209–14. doi:10.1182/blood.V96.9.3209. PMID 11050005.
^ "Entrez Gene: PRDM16 PR domain containing 16".
^ ^a ^b Patrick Seale, Heather M. Conroe, Jennifer Estall, Shingo Kajimura, Andrea Frontini, Jeff Ishibashi, Paul Cohen, Saverio Cinti, Bruce M. Spiegelman (January 2011). "Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice". The Journal of Clinical Investigation. 121 (1): 96–105. doi:10.1172/JCI44271. PMC 3007155. PMID 21123942.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000142611 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039410 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11050005-5] Mochizuki N, Shimizu S, Nagasawa T, Tanaka H, Taniwaki M, Yokota J, Morishita K (November 2000). "A novel gene, MEL1, mapped to 1p36.3 is highly homologous to the MDS1/EVI1 gene and is transcriptionally activated in t(1;3)(p36;q21)-positive leukemia cells". Blood. 96 (9): 3209–14. doi:10.1182/blood.V96.9.3209. PMID 11050005.

[entrez-6] "Entrez Gene: PRDM16 PR domain containing 16".

[prdm16-7] Patrick Seale, Heather M. Conroe, Jennifer Estall, Shingo Kajimura, Andrea Frontini, Jeff Ishibashi, Paul Cohen, Saverio Cinti, Bruce M. Spiegelman (January 2011). "Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice". The Journal of Clinical Investigation. 121 (1): 96–105. doi:10.1172/JCI44271. PMC 3007155. PMID 21123942.

PRDM16 information

and 12 Related for: PRDM16 information

PRDM16

Brown adipose tissue

Adipose tissue

Adipocyte

List of human transcription factors

Gene therapy

Chronic granulomatous disease

TMED5

Corey Harwell

SETBP1

CTBP2

SMIM23