Protein-coding gene in the species Homo sapiens
For the anti-inflammatory ointment called Picalm, see Piketoprofen.
PICALM Identifiers Aliases PICALM , CALM, CLTH, LAP, phosphatidylinositol binding clathrin assembly proteinExternal IDs OMIM: 603025; MGI: 2385902; HomoloGene: 111783; GeneCards: PICALM; OMA:PICALM - orthologs Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q14.2 Start 85,957,175 bp[1] End 86,069,882 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 D3|7 50.47 cM Start 89,779,421 bp[2] End 89,862,673 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon tibial arteries corpus callosum subcutaneous adipose tissue gallbladder tibial nerve monocyte right coronary artery C1 segment ascending aorta
Top expressed in interventricular septum left lung lobe belly cord body of femur calvaria sciatic nerve dermis spleen seminal vesicula brown adipose tissue
More reference expression data
BioGPS More reference expression data
Gene ontology Molecular function
clathrin heavy chain binding
clathrin adaptor activity
clathrin binding
1-phosphatidylinositol binding
protein binding
phospholipid binding
cadherin binding
SNARE binding
amyloid-beta binding
phosphatidylinositol-4,5-bisphosphate binding
tau protein binding
low-density lipoprotein particle receptor binding
Cellular component
clathrin coat of coated pit
Golgi apparatus
postsynaptic membrane
membrane
neurofibrillary tangle
neuronal cell body
clathrin-coated pit
AP-2 adaptor complex
presynaptic membrane
cytoplasmic vesicle
nucleus
clathrin-coated vesicle
intracellular anatomical structure
vesicle
perinuclear region of cytoplasm
cytosol
intracellular membrane-bounded organelle
early endosome
plasma membrane
cell surface
intrinsic component of membrane
clathrin-coated endocytic vesicle
endosome to plasma membrane transport vesicle
synaptic vesicle
extrinsic component of presynaptic endocytic zone membrane
Biological process
regulation of endocytosis
endocytosis
iron ion homeostasis
receptor internalization
positive regulation of neuron death
regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
negative regulation of gene expression
regulation of protein localization
negative regulation of receptor-mediated endocytosis
positive regulation of transcription, DNA-templated
endosomal transport
clathrin coat assembly
cell population proliferation
vesicle-mediated transport
axonogenesis
hemopoiesis
clathrin-dependent endocytosis
negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
synaptic vesicle maturation
positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
vesicle cargo loading
receptor-mediated endocytosis
dendrite morphogenesis
positive regulation of amyloid-beta formation
membrane organization
iron ion import across plasma membrane
vesicle budding from membrane
learning or memory
positive regulation of GTPase activity
protein-containing complex assembly
regulation of vesicle size
membrane bending
amyloid-beta clearance by transcytosis
regulation of amyloid-beta formation
negative regulation of protein localization to plasma membrane
clathrin-coated pit assembly
negative regulation of protein localization to cell surface
synaptic vesicle budding from presynaptic endocytic zone membrane
synaptic vesicle endocytosis
Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) NM_001008660 NM_001206946 NM_001206947 NM_007166
NM_001252520 NM_001252521 NM_001252522 NM_001252523 NM_001252524 NM_146194 NM_001360867
RefSeq (protein) NP_001008660 NP_001193875 NP_001193876 NP_009097 NP_001008660.1
NP_001239449 NP_001239450 NP_001239451 NP_001239452 NP_001239453 NP_666306 NP_001347796
Location (UCSC) Chr 11: 85.96 – 86.07 Mb Chr 7: 89.78 – 89.86 Mb PubMed search [3] [4]
Wikidata View/Edit Human View/Edit Mouse
Phosphatidylinositol binding clathrin assembly protein , also known as PICALM , is a protein which in humans is encoded by the PICALM gene.[5]
^ a b c GRCh38: Ensembl release 89: ENSG00000073921 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039361 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Entrez Gene: PICALM phosphatidylinositol binding clathrin assembly protein".
Last Update: 2023-03-04T00:44:58Z
clathrin assembly protein, also known as PICALM , is a protein which in humans is encoded by the PICALM gene. PICALM has been shown to interact with CLTC....
Word Count : 977
Last Update: 2024-03-09T23:16:26Z
Gene loci Neurological disease APOE ε4, PICALM Alzheimer's disease C9orf72, SOD1 amyotrophic lateral sclerosis HTT Huntington's disease DR15, DQ6 Multiple...
Word Count : 3357
Last Update: 2023-01-24T19:25:46Z
Piketoprofen (INN; trade names Calmatel, Picalm ) is a nonsteroidal anti-inflammatory drug (NSAID) for topical use in form of a cream. Chemically, it is...
Word Count : 119
Last Update: 2023-11-15T07:30:10Z
with phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia (PICALM ), which would serve as an important receptor group for microtubule-associated...
Word Count : 1387
Last Update: 2024-01-24T05:09:10Z
(Oct 2009). "Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease". Nature Genetics. 41 (10): 1088–93...
Word Count : 2433
Last Update: 2023-08-18T08:20:27Z
heavy chains and three light chains. CLTC has been shown to interact with PICALM and HGS. Clathrin GRCh38: Ensembl release 89: ENSG00000141367 – Ensembl...
Word Count : 1087
Last Update: 2024-06-02T18:45:47Z
HIP1R, and the PtdIns(4,5)P2 binding sequence is conserved. HIP1; HIP1R; PICALM ; SNAP91; "Clathrin and its interactions with AP180". Archived from the original...
Word Count : 275
Last Update: 2024-05-09T15:43:25Z
Leukemia, acute myeloid; 601626; NUP214 Leukemia, acute myeloid; 601626; PICALM Leukemia, acute myeloid; 601626; RUNX1 Leukemia, acute myeloid; 601626;...
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