PDZK1 information

PDZK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EEI, 2EEJ, 2VSP, 3TMH, 4Q2P
Identifiers
Aliases	PDZK1, CAP70, CLAMP, NHERF-3, NHERF3, PDZD1, PDZ domain containing 1
External IDs	OMIM: 603831; MGI: 1928901; HomoloGene: 1964; GeneCards: PDZK1; OMA:PDZK1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	145,708,148 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	96,778,242 bp
RNA expression pattern
	Top expressed in
	duodenum; ; right lobe of liver; ; cerebellar cortex; ; cerebellar hemisphere; ; gallbladder; ; human kidney; ; right hemisphere of cerebellum; ; body of pancreas; ; islet of Langerhans; ; testicle;
	Top expressed in
	right kidney; ; human kidney; ; proximal tubule; ; efferent ductule; ; yolk sac; ; seminiferous tubule; ; jejunum; ; spermatid; ; primary oocyte; ; ileum;
	More reference expression data
	n/a
Gene ontology
Molecular function	scavenger receptor binding; protein-containing complex binding; PDZ domain binding; protein binding; transporter activity;
Cellular component	membrane raft; brush border membrane; plasma membrane; extracellular exosome; apical plasma membrane; membrane; microvillus membrane;
Biological process	cell population proliferation; carnitine transport; positive regulation of ion transmembrane transport; regulation of anion transport; positive regulation of protein targeting to membrane; transport; positive regulation of ion transmembrane transporter activity; positive regulation of cation transmembrane transport; xenobiotic detoxification by transmembrane export across the plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	5174
	59020
	ENSG00000174827
	ENSMUSG00000038298
	Q5T2W1
	Q9JIL4
	NM_001201325; NM_001201326; NM_002614
	NM_001146001; NM_021517; NM_001355710
	NP_001188254; NP_001188255; NP_002605; NP_001358288; NP_001358290
	NP_001139473; NP_067492; NP_001342639
	Wikidata
View/Edit Human	View/Edit Mouse

Na(+)/H(+) exchange regulatory cofactor NHE-RF3 is a protein that in humans is encoded by the PDZK1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000174827 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038298 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kocher O, Comella N, Tognazzi K, Brown LF (March 1998). "Identification and partial characterization of PDZK1: a novel protein containing PDZ interaction domains". Lab Invest. 78 (1): 117–25. PMID 9461128.
^ "Entrez Gene: PDZK1 PDZ domain containing 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000174827 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038298 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9461128-5] Kocher O, Comella N, Tognazzi K, Brown LF (March 1998). "Identification and partial characterization of PDZK1: a novel protein containing PDZ interaction domains". Lab Invest. 78 (1): 117–25. PMID 9461128.

[entrez-6] "Entrez Gene: PDZK1 PDZ domain containing 1".

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