Oxalate oxidoreductases (EC 1.2.7.10) (OOR) are a relatively recently discovered group of enzymes that break down oxalate, a problematic molecule nutritionally. The first one to have been characterized has the systematic name oxalate:ferredoxin oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction:
oxalate + oxidized ferredoxin 2 CO2 + reduced ferredoxin
This enzyme contains thiamine diphosphate and [4Fe-4S] clusters.[further explanation needed]
Another OOR from acetogenic bacteria, a thiamine pyrophosphate (TPP)-dependent OOR, had its mechanism of action decoded step by step under X-ray crystallography to rather simplistically (one-carbon) split oxalate, producing low-potential electrons and CO2.[3]
^Pierce E, Becker DF, Ragsdale SW (December 2010). "Identification and characterization of oxalate oxidoreductase, a novel thiamine pyrophosphate-dependent 2-oxoacid oxidoreductase that enables anaerobic growth on oxalate". The Journal of Biological Chemistry. 285 (52): 40515–24. doi:10.1074/jbc.M110.155739. PMC 3003350. PMID 20956531.
^Gibson MI, Chen PY, Johnson AC, Pierce E, Can M, Ragsdale SW, Drennan CL (January 2016). "One-carbon chemistry of oxalate oxidoreductase captured by X-ray crystallography". Proceedings of the National Academy of Sciences of the United States of America. 113 (2): 320–5. Bibcode:2016PNAS..113..320G. doi:10.1073/pnas.1518537113. PMC 4720323. PMID 26712008.
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Oxalateoxidoreductases (EC 1.2.7.10) (OOR) are a relatively recently discovered group of enzymes that break down oxalate, a problematic molecule nutritionally...
this enzyme are oxalate, O2, and H+, whereas its two products are CO2 and H2O2. This enzyme belongs to the family of oxidoreductases, specifically those...
\rightleftharpoons } oxalate + H2O2 The 3 substrates of this enzyme are glyoxylate, H2O, and O2, whereas its two products are oxalate and H2O2. This enzyme...
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acceptor. The systematic name of this enzyme class is (R)-glycerate:NAD+ oxidoreductase. Other names in common use include D-glycerate dehydrogenase, and hydroxypyruvate...
accumulation of the end product of the ethylene glycol mechanism, calcium oxalate, may cause malfunction in the kidney and lead to more severe consequences...
in organisms. The cytochrome b5 reductase enzyme contains a typical oxidoreductase structure with a diaphorase binding domain complex for NADH and a FAD-binding...
or NADPH. The systematic name of this enzyme class is glycolate:NAD+ oxidoreductase. Other names in common use include NADH-glyoxylate reductase, glyoxylic...
plain X-ray. Uric acid crystals can also promote the formation of calcium oxalate stones, acting as "seed crystals". Hyperuricemia is associated with components...
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photographic processes. The dihydrate of iron(II) oxalate has a polymeric structure with co-planar oxalate ions bridging between iron centres with the water...
site of the mitochondrial electron transport chain. NADH/ubiquinone oxidoreductase, also known as complex I, is the first and largest protein in the mitochondrial...
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Oxidoreductase D (DsbD) Family 5.A.2 The Disulfide Bond Oxidoreductase B (DsbB) Family 5.A.3 The Prokaryotic Molybdopterin-containing Oxidoreductase (PMO)...
membrane include two-electron carriers, such as the disulfide bond oxidoreductases (DsbB and DsbD in E. coli) as well as one-electron carriers such as...
dicarboxylic acid transport sulfide oxidation, using sulfide:quinone oxidoreductase ion transport mitochondrial transport sulfate transport thiosulfate...
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