In molecular biology, Ornithine decarboxylase antizyme (ODC-AZ) is an ornithine decarboxylase inhibitor. It binds to, and destabilises, ornithine decarboxylase (ODC), a key enzyme in polyamine synthesis. ODC is then rapidly degraded.[1] It was first characterized in 1981.[2] The expression of ODC-AZ requires programmed, ribosomal frameshifting which is modulated according to the cellular concentration of polyamines. High levels of polyamines induce a +1 ribosomal frameshift in the translation of mRNA for the antizyme leading to the expression of a full-length protein. At least two forms of ODC-AZ exist in mammals [3] and the protein has been found in Drosophila (protein Gutfeeling[4]) as well as in Saccharomyces yeast (encoded by the OAZ1 gene).[5]
Human genes encoding Ornithine decarboxylase antizymes are OAZ1, OAZ2, and OAZ3.
^Matsufuji S, Matsufuji T, Miyazaki Y, Murakami Y, Atkins JF, Gesteland RF, Hayashi S (January 1995). "Autoregulatory frameshifting in decoding mammalian ornithine decarboxylase antizyme". Cell. 80 (1): 51–60. doi:10.1016/0092-8674(95)90450-6. PMC 7133313. PMID 7813017.
^Heller JS, Canellakis ES (1981). "Cellular control of ornithine decarboxylase activity by its antizyme". J. Cell. Physiol. 107 (2): 209–17. doi:10.1002/jcp.1041070206. PMID 7251680. S2CID 31895913.
^Ivanov IP, Gesteland RF, Atkins JF (September 1998). "A second mammalian antizyme: conservation of programmed ribosomal frameshifting". Genomics. 52 (2): 119–29. doi:10.1006/geno.1998.5434. PMID 9782076.
^Salzberg, A.; Golden, K.; Bodmer, R.; Bellen, H. J. (1996-09-01). "Gutfeeling, a Drosophila Gene Encoding an Antizyme-like Protein, Is Required for Late Differentiation of Neurons and Muscles". Genetics. 144 (1): 183–196. doi:10.1093/genetics/144.1.183. ISSN 0016-6731. PMC 1207492. PMID 8878684.
^SGD entry for OAZ1 gene
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biology, Ornithinedecarboxylaseantizyme (ODC-AZ) is an ornithinedecarboxylase inhibitor. It binds to, and destabilises, ornithinedecarboxylase (ODC)...
The enzyme ornithinedecarboxylase (EC 4.1.1.17, ODC) catalyzes the decarboxylation of ornithine (a product of the urea cycle) to form putrescine. This...
Ornithinedecarboxylaseantizyme is an enzyme that in humans is encoded by the OAZ1 gene. Ornithinedecarboxylase catalyzes the conversion of ornithine...
Antizyme inhibitor 1 is a protein that in humans is encoded by the AZIN1 gene. Ornithinedecarboxylase (ODC) catalyzes the conversion of ornithine to putrescine...
Ornithinedecarboxylaseantizyme 2 is an enzyme that in humans is encoded by the OAZ2 gene. Ornithinedecarboxylase catalyzes the conversion of ornithine...
increase in the quantity of functional antizyme produced. The functional antizyme acts to reduce ornithinedecarboxylase (ODC) activity which leads to a drop...
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Antizyme inhibitor 2 (AzI2) also erroneously known as arginine decarboxylase (ADC) is a protein that in humans is encoded by the AZIN2 gene. In contrast...
Polyamine metabolism is regulated by the activity of the enzyme ornithinedecarboxylase (ODC). Polyamines are found in high concentrations in the mammalian...
decarboxylation of L-arginine by the mitochondrial enzyme arginine decarboxylase (ADC). Agmatine degradation occurs mainly by hydrolysis, catalyzed by...
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