dentate gyrus of hippocampal formation granule cell
mesencephalon
hypothalamus
heart
superior frontal gyrus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
ornithine decarboxylase inhibitor activity
protein binding
Cellular component
cytosol
nucleus
cytoplasm
Biological process
positive regulation of intracellular protein transport
polyamine biosynthetic process
polyamine metabolic process
negative regulation of polyamine transmembrane transport
negative regulation of catalytic activity
regulation of cellular amino acid metabolic process
positive regulation of protein catabolic process
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
4947
18247
Ensembl
ENSG00000180304
ENSMUSG00000040652
UniProt
O95190
O08608
RefSeq (mRNA)
NM_002537 NM_001301302
NM_001301307 NM_010952
RefSeq (protein)
NP_001288231 NP_002528
NP_001288236 NP_035082
Location (UCSC)
Chr 15: 64.69 – 64.7 Mb
Chr 9: 65.58 – 65.6 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Ornithine decarboxylase antizyme 2 is an enzyme that in humans is encoded by the OAZ2 gene.[5][6][7]
Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translational frameshifting. The antizyme encoded by this gene inhibits ornithine decarboxylase but does not accelerate its degradation.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000180304 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000040652 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Ivanov IP, Gesteland RF, Atkins JF (Dec 1998). "A second mammalian antizyme: conservation of programmed ribosomal frameshifting". Genomics. 52 (2): 119–29. doi:10.1006/geno.1998.5434. PMID 9782076.
Ornithine decarboxylase antizyme 2 is an enzyme that in humans is encoded by the OAZ2 gene. Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine...
humans is encoded by the OAZ1 gene OAZ2, ornithine decarboxylase antizyme 2, an enzyme that in humans is encoded by the OAZ2 gene Outer Artillery Zone, a narrow...
gene). Human genes encoding Ornithine decarboxylase antizymes are OAZ1, OAZ2, and OAZ3. Matsufuji S, Matsufuji T, Miyazaki Y, Murakami Y, Atkins JF, Gesteland...