OAZ1 information

OAZ1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4ZGY, 4ZGZ, 5BWA
Identifiers
Aliases	OAZ1, AZI, OAZ, ornithine decarboxylase antizyme 1, AZ1
External IDs	OMIM: 601579; MGI: 109433; HomoloGene: 7455; GeneCards: OAZ1; OMA:OAZ1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	2,273,490 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	80,665,124 bp
RNA expression pattern
	Top expressed in
	pons; ; blood; ; pylorus; ; Pars compacta; ; renal medulla; ; superior vestibular nucleus; ; monocyte; ; cardia; ; postcentral gyrus; ; parotid gland;
	Top expressed in
	bone marrow; ; neural layer of retina; ; secondary oocyte; ; proximal tubule; ; zygote; ; right kidney; ; mesencephalon; ; quadriceps femoris muscle; ; neural tube; ; thymus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	ornithine decarboxylase inhibitor activity; protein binding;
Cellular component	cytosol; nucleus; cytoplasm;
Biological process	positive regulation of intracellular protein transport; polyamine biosynthetic process; negative regulation of polyamine transmembrane transport; negative regulation of catalytic activity; regulation of cellular amino acid metabolic process; positive regulation of protein catabolic process; polyamine metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	4946
	18245
	ENSG00000104904
	ENSMUSG00000035242
	P54368
	P54369
	NM_004152; NM_001301020
	NM_001301034; NM_008753
	NP_001287949; NP_004143
	NP_001287963; NP_032779
	Wikidata
View/Edit Human	View/Edit Mouse

Ornithine decarboxylase antizyme is an enzyme that in humans is encoded by the OAZ1 gene.^[5]^[6]^[7]

Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translational frameshifting. The antizyme encoded by this gene inhibits ornithine decarboxylase and accelerates its degradation.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000104904 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035242 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tewari DS, Qian Y, Thornton RD, Pieringer J, Taub R, Mochan E, Tewari M (Feb 1995). "Molecular cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme". Biochim Biophys Acta. 1209 (2): 293–5. doi:10.1016/0167-4838(94)90199-6. PMID 7811704.
^ Matsufuji S, Inazawa J, Hayashi T, Miyazaki Y, Ichiba T, Furusaka A, Matsufuji T, Atkins JF, Gesteland RF, Murakami Y, Hayashi S (Mar 1997). "Assignment of the human antizyme gene (OAZ) to chromosome 19p13.3 by fluorescence in situ hybridization". Genomics. 38 (1): 102–104. doi:10.1006/geno.1996.0601. PMID 8954789.
^ ^a ^b "Entrez Gene: OAZ1 ornithine decarboxylase antizyme 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000104904 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035242 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7811704-5] Tewari DS, Qian Y, Thornton RD, Pieringer J, Taub R, Mochan E, Tewari M (Feb 1995). "Molecular cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme". Biochim Biophys Acta. 1209 (2): 293–5. doi:10.1016/0167-4838(94)90199-6. PMID 7811704.

[pmid8954789-6] Matsufuji S, Inazawa J, Hayashi T, Miyazaki Y, Ichiba T, Furusaka A, Matsufuji T, Atkins JF, Gesteland RF, Murakami Y, Hayashi S (Mar 1997). "Assignment of the human antizyme gene (OAZ) to chromosome 19p13.3 by fluorescence in situ hybridization". Genomics. 38 (1): 102–104. doi:10.1006/geno.1996.0601. PMID 8954789.

[entrez-7] "Entrez Gene: OAZ1 ornithine decarboxylase antizyme 1".