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Nikethamide information


Nikethamide
Clinical data
Other namesNicotinic acid diethylamide
AHFS/Drugs.comInternational Drug Names
ATC code
  • R07AB02 (WHO)
Pharmacokinetic data
Elimination half-life0.5 h
Identifiers
IUPAC name
  • N,N-Diethyl-3-pyridinecarboxamide
CAS Number
  • 59-26-7 checkY
PubChem CID
  • 5497
DrugBank
  • DB13655
ChemSpider
  • 5296 checkY
UNII
  • 368IVD6M32
KEGG
  • D07408 checkY
ChEBI
  • CHEBI:134814
ChEMBL
  • ChEMBL2104607
CompTox Dashboard (EPA)
  • DTXSID9046524 Edit this at Wikidata
ECHA InfoCard100.000.380 Edit this at Wikidata
Chemical and physical data
FormulaC10H14N2O
Molar mass178.235 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • O=C(N(CC)CC)c1cccnc1
InChI
  • InChI=1S/C10H14N2O/c1-3-12(4-2)10(13)9-6-5-7-11-8-9/h5-8H,3-4H2,1-2H3 checkY
  • Key:NCYVXEGFNDZQCU-UHFFFAOYSA-N checkY
  (verify)

Nikethamide is a stimulant which mainly affects the respiratory cycle. Widely known by its former trade name of Coramine, it was used in the mid-twentieth century as a medical countermeasure against tranquilizer overdoses, before the advent of endotracheal intubation and positive-pressure lung expansion. It is no longer commonly considered to be of value for such purposes.

In alternate terminology, it is known as nicotinic acid diethylamide, which meaningfully emphasizes its laboratory origins, and of which its common name is derived as a blend.

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Nikethamide

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Nikethamide is a stimulant which mainly affects the respiratory cycle. Widely known by its former trade name of Coramine, it was used in the mid-twentieth...

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Analeptic

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drugs of this category are prethcamide, pentylenetetrazole, and nikethamide. Nikethamide is now withdrawn due to risk of convulsions. Analeptics have recently...

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ATC code R07

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Natural phospholipids R07AA30 Combinations R07AB01 Doxapram R07AB02 Nikethamide R07AB03 Pentetrazol R07AB04 Etamivan R07AB05 Bemegride R07AB06 Prethcamide...

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Hypoventilation

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monitored very carefully, nonetheless. Respiratory stimulants such as nikethamide were traditionally used to counteract respiratory depression from CNS...

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Methamnetamine Methastyridone Methiopropamine Naphthylaminopropane Nefopam Nikethamide Nomifensine O-2172 Oxaprotiline PNU-99,194 PRC200-SS Rasagiline Rauwolscine...

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MDMA

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Methamnetamine Methastyridone Methiopropamine Naphthylaminopropane Nefopam Nikethamide Nomifensine O-2172 Oxaprotiline PNU-99,194 PRC200-SS Rasagiline Rauwolscine...

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Albert Hofmann

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circulatory stimulant (analeptic) with no effects on the uterus in analogy to nikethamide (which is also a diethylamide) by introducing this functional group to...

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C10H14N2O

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g/mol, exact mass: 178.1106 u) may refer to: Bupicomide Epiboxidine Nikethamide This set index page lists chemical structure articles associated with...

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Methamnetamine Methastyridone Methiopropamine Naphthylaminopropane Nefopam Nikethamide Nomifensine O-2172 Oxaprotiline PNU-99,194 PRC200-SS Rasagiline Rauwolscine...

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Methamphetamine

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Methamnetamine Methastyridone Methiopropamine Naphthylaminopropane Nefopam Nikethamide Nomifensine O-2172 Oxaprotiline PNU-99,194 PRC200-SS Rasagiline Rauwolscine...

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Methamnetamine Methastyridone Methiopropamine Naphthylaminopropane Nefopam Nikethamide Nomifensine O-2172 Oxaprotiline PNU-99,194 PRC200-SS Rasagiline Rauwolscine...

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Psychoactive drug

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Methamnetamine Methastyridone Methiopropamine Naphthylaminopropane Nefopam Nikethamide Nomifensine O-2172 Oxaprotiline PNU-99,194 PRC200-SS Rasagiline Rauwolscine...

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Methamnetamine Methastyridone Methiopropamine Naphthylaminopropane Nefopam Nikethamide Nomifensine O-2172 Oxaprotiline PNU-99,194 PRC200-SS Rasagiline Rauwolscine...

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Methamnetamine Methastyridone Methiopropamine Naphthylaminopropane Nefopam Nikethamide Nomifensine O-2172 Oxaprotiline PNU-99,194 PRC200-SS Rasagiline Rauwolscine...

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Methamnetamine Methastyridone Methiopropamine Naphthylaminopropane Nefopam Nikethamide Nomifensine O-2172 Oxaprotiline PNU-99,194 PRC200-SS Rasagiline Rauwolscine...

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Coca

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Methamnetamine Methastyridone Methiopropamine Naphthylaminopropane Nefopam Nikethamide Nomifensine O-2172 Oxaprotiline PNU-99,194 PRC200-SS Rasagiline Rauwolscine...

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Methamnetamine Methastyridone Methiopropamine Naphthylaminopropane Nefopam Nikethamide Nomifensine O-2172 Oxaprotiline PNU-99,194 PRC200-SS Rasagiline Rauwolscine...

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Methamnetamine Methastyridone Methiopropamine Naphthylaminopropane Nefopam Nikethamide Nomifensine O-2172 Oxaprotiline PNU-99,194 PRC200-SS Rasagiline Rauwolscine...

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Theodor Morell

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common colds and flu. Cocaine and adrenaline (via eye drops). Coramine: Nikethamide injected when unduly sedated with barbiturates. In addition, Morell would...

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Methamnetamine Methastyridone Methiopropamine Naphthylaminopropane Nefopam Nikethamide Nomifensine O-2172 Oxaprotiline PNU-99,194 PRC200-SS Rasagiline Rauwolscine...

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Methamnetamine Methastyridone Methiopropamine Naphthylaminopropane Nefopam Nikethamide Nomifensine O-2172 Oxaprotiline PNU-99,194 PRC200-SS Rasagiline Rauwolscine...

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In 2013, Marin Čilić returned a positive drug test for the substance nikethamide. The drug is a widely used stimulant that affects respiratory function...

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