Brain MRI, T1 weighted on a transversal plane, of an 8-month old boy with lissencephaly. Note the scarce and wide gyri, mostly on the parietal, temporal and occipital lobes, the absence of a true Sylvian fissure, and the augmented thickness of the gray matter. The boy had a severe developmental delay and seizures.
Specialty
Neurology
Neuronal migration disorder (NMD) refers to a heterogenous group of disorders that, it is supposed, share the same etiopathological mechanism: a variable degree of disruption in the migration of neuroblasts during neurogenesis.[1] The neuronal migration disorders are termed cerebral dysgenesis disorders, brain malformations caused by primary alterations during neurogenesis; on the other hand, brain malformations are highly diverse and refer to any insult to the brain during its formation and maturation due to intrinsic or extrinsic causes that ultimately will alter the normal brain anatomy. However, there is some controversy in the terminology because virtually any malformation will involve neuroblast migration, either primarily or secondarily.
^Sarnat, Harvey (1992). Cerebral dysgenesis, embryology and clinical expression. New York, US: Oxford University Press. ISBN 978-0-19-506442-1.
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Neuronalmigrationdisorder (NMD) refers to a heterogenous group of disorders that, it is supposed, share the same etiopathological mechanism: a variable...
characteristics of the brain in association with several neuronalmigrationdisorders; most commonly disorders relating to varied degrees of lissencephaly. Lissencephaly...
of rare brain disorders whereby the whole or parts of the surface of the brain appear smooth. It is caused by defective neuronalmigration during the 12th...
not known yet, it is commonly believed to occur as a result of neuronalmigrationdisorders during early brain development, intrauterine disturbances, perinatal...
descent Norwegian Maritime Directorate Naturopathic medical doctor Neuronalmigrationdisorder Adidas NMD, a running shoe This disambiguation page lists articles...
mediating some aspects of these processes such as the rate of neuronalmigration, aspects of neuronal differentiation and axon pathfinding. Activity-dependent...
initials related to diseases (infectious or non-infectious) and medical disorders. Acronyms in healthcare List of medical abbreviations: Overview List of...
malformation, neuronalmigrationdisorders, infections such as encephalitis and meningitis, autoimmune disease (limbic encephalitis) and genetic disorders may cause...
to describe brain characteristics in association with several neuronalmigrationdisorders; most commonly relating to lissencephaly. Lissencephaly (smooth...
in the pathophysiology of microlissencephaly as well as other neuronalmigrationdisorders. Congenital infections like cytomegalovirus are also known to...
Micropolygyria is a neuronalmigrationdisorder, a developmental anomaly of the brain characterized by development of numerous small convolutions (microgyri)...
Lis1 that is responsible for stabilization of neurotubule during neuronalmigration by minimizing neurotubule catastrophe. It also regulates the motor...
apolipoprotein E-containing triacylglycerol-rich lipoproteins, and neuronalmigration in the developing brain. In humans, VLDLR is encoded by the VLDLR...
several disorders known as neuronalmigrationdisorders that can cause serious problems. These arise from a disruption in the pattern of migration of the...
zoster virus.[additional citation(s) needed] Polymicrogyria is a disorder of neuronalmigration, resulting in structurally abnormal cerebral hemispheres. The...
humans, the GEs disappear by one year of age. During development, neuronalmigration continues until the extinction of the germ layer, at which point the...
is a disorder in which the brain does not properly form the gyri and sulci as a result from neuronalmigration and cortical folding. This disorder can...
the migration of neurons to the cerebral cortex. Gray matter heterotopia are common malformations of cortical development known as neuronalmigration disorders...
toxicity. The latter interferes with proliferation, differentiation, neuronalmigration, axonic outgrowth, integration, and fine-tuning of the synaptic network...
dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronalmigration". Human Molecular Genetics. 15 (10): 1659–1666. doi:10.1093/hmg/ddl089...
need of a neuronal scaffold such as along a radial glial cell. For this reason the crest cell migration process is termed "free migration". Instead of...
MicroRNAs are highly influential in early neuronal development, and their disruption is implicated in several CNS disorders; circulating microRNAs (cimiRNAs)...
Neuronalmigration protein doublecortin, also known as doublin or lissencephalin-X is a protein that in humans is encoded by the DCX gene. Doublecortin...
regulatory subunit 1B (PPP1R1B), also known as dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32), is a protein that in humans is encoded by the...
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