Nalorphine (INNTooltip International Nonproprietary Name) (brand names Lethidrone, Nalline), also known as N-allylnormorphine, is a mixed opioid agonist–antagonist with opioid antagonist and analgesic properties.[2] It was introduced in 1954[3] and was used as an antidote to reverse opioid overdose and in a challenge test to determine opioid dependence.[4]
Nalorphine was the second opioid antagonist to be introduced, preceded by nalodeine (N-allylnorcodeine) in 1915 and followed by naloxone in 1960 and naltrexone in 1963.[3] Due to potent activation of the κ-opioid receptor, nalorphine produces side effects such as dysphoria, anxiety, confusion, and hallucinations, and for this reason, is no longer used medically.[2][3][5]
^Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-03.
^ abGlatt M (6 December 2012). The Dependence Phenomenon. Springer Science & Business Media. pp. 121–. ISBN 978-94-011-7457-2.
^ abcAggrawal A. APC Essentials of Forensic Medicine and Toxicology. Avichal Publishing Company. pp. 554–. ISBN 978-81-7739-441-2.
^"Medicine: Drug Detector". Time. 24 December 1956. Archived from the original on July 26, 2005.
^Satoskar RS, Rege N, Bhandarkar SD (27 July 2015). Pharmacology and Pharmacotherapeutics. Elsevier Health Sciences APAC. pp. 166–. ISBN 978-81-312-4371-8.
Nalorphine (INNTooltip International Nonproprietary Name) (brand names Lethidrone, Nalline), also known as N-allylnormorphine, is a mixed opioid agonist–antagonist...
Nalorphine dinicotinate (trade name Nimelan), also known as N-allylnormorphine dinicotinate, dinicotinoylnalorphine, or niconalorphine, is a semisynthetic...
doses to opioid-naive individuals. Examples of such compounds include nalorphine and levallorphan. However, the analgesic effects from these specific drugs...
6-diacetyl ester of nalorphine, and therefore the heroin analogue of nalorphine. Diacetylnalorphine may behave as a prodrug to nalorphine, similarly to the...
C19H21NO3 (molar mass: 311.37 g/mol, exact mass: 311.1521 u) may refer to: Nalorphine, also known as N-allylnormorphine 2-OH-NPA Thebaine, also known as paramorphine...
which considers it a class A drug. Levallorphan Nalbuphine Nalfurafine Nalorphine Xorphanol Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes...
intermediate which can be used to produce both opioid antagonists such as nalorphine, and also potent opioid agonists such as N-phenethylnormorphine. with...
PMC 2424120. PMID 18568113. U.S. patent 3,461,461 Boyd E M, Pearl M. Can nalorphine hydrochloride prevent respiratory depression and death from overdose of...
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