Protein-coding gene in humans
NPRL3 Identifiers Aliases NPRL3 , C16orf35, CGTHBA, HS-40, MARE, NPR3, RMD11, NPR3 like, GATOR1 complex subunit, FFEVF3External IDs OMIM: 600928; MGI: 109258; HomoloGene: 8091; GeneCards: NPRL3; OMA:NPRL3 - orthologs Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 84,271 bp[1] End 138,677 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 A4|11 18.83 cM Start 32,175,628 bp[2] End 32,217,707 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood muscle of thigh right uterine tube left ovary right ovary right hemisphere of cerebellum apex of heart right adrenal gland right adrenal cortex right frontal lobe
Top expressed in muscle of thigh neural layer of retina lip spermatocyte dentate gyrus of hippocampal formation granule cell superior frontal gyrus right kidney primary visual cortex ventricular zone interventricular septum
More reference expression data
BioGPS
Gene ontology Molecular function
GTPase activator activity
protein binding
Cellular component
GATOR1 complex
lysosome
lysosomal membrane
membrane
Biological process
negative regulation of TOR signaling
cellular response to amino acid starvation
roof of mouth development
ventricular septum development
aorta morphogenesis
cardiac muscle tissue development
positive regulation of GTPase activity
TORC1 signaling
regulation of autophagosome assembly
Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) NM_001039476 NM_001077350 NM_001243247 NM_001243248 NM_001243249 NM_012075
NM_001284359 NM_001284360 NM_181569
RefSeq (protein) NP_001034565 NP_001070818 NP_001230176 NP_001230177 NP_001230178
NP_001271288 NP_001271289 NP_853547
Location (UCSC) Chr 16: 0.08 – 0.14 Mb Chr 11: 32.18 – 32.22 Mb PubMed search [3] [4]
Wikidata View/Edit Human View/Edit Mouse
Nitrogen permease regulator-like 3 is a protein that in humans is encoded by the NPRL3 gene.[5]
^ a b c GRCh38: Ensembl release 89: ENSG00000103148 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020289 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Entrez Gene: Nitrogen permease regulator-like 3 (S. cerevisiae)".
Last Update: 2023-05-31T14:22:44Z
NPRL3 gene. NPRL3 is a human protein of poorly understood function but has been associated with cancer. The most prominent function ascribed to Nprl3 ...
Word Count : 648
Last Update: 2024-04-11T11:01:43Z
conserved complexes: the "GATOR1" complex containing DEPDC5, NPRL2 and NPRL3 and the ""GATOR2" complex containing Mios, WDR24, WDR59, Seh1L, Sec13. GATOR1...
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Last Update: 2024-03-10T06:33:49Z
transcription factor MYC. DEPDC5 is in the "GATOR1" complex with NPRL2 and NPRL3 . GRCh38: Ensembl release 89: ENSG00000100150 – Ensembl, May 2017 GRCm38:...
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