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NNK information


Nicotine-derived nitrosone (NNK)
Names
Preferred IUPAC name
Methyl[4-oxo-4-(pyridin-3-yl)butyl]nitrous amide
Other names
N-Nitrosonornicotine ketone; 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone
Identifiers
CAS Number
  • 64091-91-4 ☒N
3D model (JSmol)
  • Interactive image
Beilstein Reference
3548355
ChEBI
  • CHEBI:32692 checkY
ChEMBL
  • ChEMBL2311069 checkY
ChemSpider
  • 43038 ☒N
ECHA InfoCard 100.164.147 Edit this at Wikidata
KEGG
  • C16453 checkY
PubChem CID
  • 47289
UNII
  • 7S395EDO61 checkY
UN number 2811
CompTox Dashboard (EPA)
  • DTXSID3020881 Edit this at Wikidata
InChI
  • InChI=1S/C10H13N3O2/c1-13(12-15)7-3-5-10(14)9-4-2-6-11-8-9/h2,4,6,8H,3,5,7H2,1H3
    Key: FLAQQSHRLBFIEZ-UHFFFAOYSA-N
SMILES
  • CN(CCCC(=O)c1cccnc1)N=O
Properties
Chemical formula
C10H13N3O2
Molar mass 207.233 g·mol−1
Hazards
GHS labelling:
Pictograms
GHS06: ToxicGHS07: Exclamation markGHS08: Health hazard
Signal word
Danger
Hazard statements
H301, H302, H317, H351
Precautionary statements
P201, P202, P261, P264, P270, P272, P280, P281, P301+P310, P301+P312, P302+P352, P308+P313, P321, P330, P333+P313, P363, P405, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Nicotine-derived nitrosamine ketone (NNK) is one of the key tobacco-specific nitrosamines derived from nicotine. It plays an important role in carcinogenesis.[1] The conversion of nicotine to NNK entails opening of the pyrrolidine ring.

  1. ^ Akopyan, Gohar; Bonavida, Benjamin (2006). "Understanding tobacco smoke carcinogen NNK and lung tumorigenesis". International Journal of Oncology. 29 (4): 745–52. doi:10.3892/ijo.29.4.745. PMID 16964372.

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conversion of nicotine to NNK entails opening of the pyrrolidine ring. NNK can be produced by standard methods of organic synthesis. NNK is both found in cured...

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director for training and operations of private security company NNK Special Services Group (NNK Group) until his death.[citation needed] McAleese married twice...

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Nissan Group

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NNK Rugby Stadium

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NNK Rugby Stadium is a multi-use stadium, situated in the Parow suburb of Cape Town, at the Western Cape Province in South Africa. Previously it was mostly...

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Dominici affair

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Elizabeth were murdered next to their car, a green Hillman, with registration NNK 686 which was parked in a lay-by near La Grand'Terre, the farm belonging...

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Nankina language

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Papua New Guinea. Nankina at Ethnologue (25th ed., 2022) Organised Phonology Data, Nankina Language [NNK], Teptep – Madang Province, 2011 v t e v t e...

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National Public Health Centre

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Public Health Centre (NPHC) (Hungarian: Nemzeti Népegészségügyi Központ; NNK) is a Hungarian centralised budgetary body based in Budapest having been...

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IARC group 1 Carcinogens

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2-Naphthylamine Nickel compounds 4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) N-Nitrosonornicotine (NNN) 2,3,4,7,8-Pentachlorodibenzofuran 3,4,5,3’...

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Saturation mutagenesis

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not ideal, and alternative, more restricted degenerate codons are used. 'NNK' and 'NNS' have the benefit of encoding all 20 amino acids, but still encode...

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Nitrosamine

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low-melting solid 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone 64091-91-4 NNK, 4′-(nitrosomethylamino)-1-(3-pyridyl)-1-butanone C10H15N3O2 Light yellow...

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Manenberg Rangers Masiphumelele Maties Mitchells Plain Utd Mountain Rocks NNK Noordelikes Paarl Paarl Rangers Peninsula Perel United Perseverance Pniel...

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Tobacco smoke

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polycyclic aromatic hydrocarbons (benzopyrene), tobacco-specific nitrosamines (NNK, NNN), aldehydes (acrolein, formaldehyde), carbon monoxide, hydrogen cyanide...

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Primorsky Krai

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The largest companies in the region include Far-Eastern Energy Company, NNK-Bunker, Mazda Sollers, and Vostochny Port. More than 100 deposits of coal...

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Shilha language

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sequence: ex: frḥɣ I.am.glad s by.means.of lmɛrft the.acquiantance nnk of.you frḥɣ s lmɛrft nnk I.am.glad by.means.of the.acquiantance of.you "I'm glad to make...

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Mikalai Varabei

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Group, Industrial Unitary Enterprise Oil Bitumen Plant, Interservice, NNK, NNK East) were designated as well. A BYPOL investigation has uncovered that...

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Cherifian Anthem

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abddur n yilsawn S iman nns S tafkka nns Ynkr warraw nnk Yssidmr awal nnk Dg imi inu d idammn Tayri nnk tnkr s wafaw d wafa Aytma inu d istma Uyurt ɣr tanaya...

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Biomarker

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biomarker may be an external substance itself (e.g. asbestos particles or NNK from tobacco), or a variant of the external substance processed by the body...

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Click consonant

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[ᶢꞰʱ ~ ᶢꞰˠ] gq etc. Simple nasal click Voiceless /ᵑ̊Ʞ/ ⟨nhꞰ⟩* [ŋ̊ᵑꞰ] Voiced /ᵑꞰ/ ⟨nꞰ⟩* [ŋ̈ᵑꞰ] ⟨ᵑꞰ⟩ [ᵑꞰ] nꞰ (nq etc.) Ʞn ⟨ŋꞰ⟩ nq etc. nq etc. (nꞰ) /ᵑǀ/ nq...

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Economy of Belarus

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trading companies Bremino Group, Sohra, Logex, Globalcastcom Management, NNK, and other companies. On 24 June 2021, the EU introduced the sectoral sanctions...

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Naskapi

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Indian Act were transferred to the NNK and to the James Bay Cree bands, to be exercised by their elected councils. The NNK and the James Bay Cree bands were...

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Smokeless tobacco

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"Grass roots approach to control levels of carcinogenic nitrosamines, NNN and NNK in smokeless tobacco products". Food and Chemical Toxicology. 124: 359–366...

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List of fairy chess pieces

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as it reflects the nature of this piece (Duniho). Pancake 1✴, ^n(~1/2) pNNK Chess with different armies (R. Betza, 1979) Combination of Mann and cannon-style...

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Toxication

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carcinogenic nitrosamines via NO pathway. Nicotine into the nitrosated carcinogenic NNK (4-(methylnitrosamino)- 1-(3-pyridyl)-1-butanone) in the lung. Benzo[a]pyrene...

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List of national public health agencies

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Organization (NPHO, former HCDCP;  Greece) Nemzeti Népegészségügyi Központ (NNK;  Hungary) Netherlands National Institute for Public Health and the Environment...

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The Egyptian

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ISBN 978-86-6157-008-7, Serbian translation by Veljko Nikitović and Kosta Lozanić, NNK Internacional, Belgrade, 2011 ISBN 978-9985-3-1983-3, Estonian translation...

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