Myocardin information

MYOCD
Identifiers
Aliases	MYOCD, MYCD, myocardin, MGBL
External IDs	OMIM: 606127; MGI: 2137495; HomoloGene: 17043; GeneCards: MYOCD; OMA:MYOCD - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	12,768,949 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	65,160,815 bp
RNA expression pattern
	Top expressed in
	tail of epididymis; ; saphenous vein; ; cardiac muscle tissue of right atrium; ; right ventricle; ; nipple; ; urethra; ; right coronary artery; ; superficial temporal artery; ; ascending aorta; ; smooth muscle tissue;
	Top expressed in
	ascending aorta; ; aortic valve; ; tunica media of zone of aorta; ; belly cord; ; myocardium of ventricle; ; interventricular septum; ; atrium; ; vas deferens; ; migratory enteric neural crest cell; ; cumulus cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transcription coactivator activity; R-SMAD binding; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription factor binding; histone deacetylase binding; core promoter sequence-specific DNA binding; protein binding; histone acetyltransferase binding; cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cellular component	nucleus;
Biological process	cellular component maintenance; positive regulation of transforming growth factor beta receptor signaling pathway; response to hypoxia; regulation of transcription, DNA-templated; negative regulation of cyclin-dependent protein serine/threonine kinase activity; urinary bladder development; regulation of transcription by RNA polymerase II; vascular associated smooth muscle cell differentiation; cardiac ventricle development; regulation of cell growth by extracellular stimulus; positive regulation of DNA-binding transcription factor activity; negative regulation of transcription by RNA polymerase II; smooth muscle cell differentiation; transcription, DNA-templated; regulation of phenotypic switching; vasculogenesis; positive regulation of transcription, DNA-templated; uterus development; negative regulation of skeletal muscle cell differentiation; negative regulation of cardiac muscle cell apoptotic process; heart development; muscle cell differentiation; negative regulation of amyloid-beta clearance; positive regulation of smooth muscle cell differentiation; regulation of myoblast differentiation; regulation of histone acetylation; positive regulation of cell population proliferation; negative regulation of myotube differentiation; positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation; positive regulation of cardiac vascular smooth muscle cell differentiation; positive regulation of cardiac muscle cell differentiation; ventricular cardiac muscle cell differentiation; positive regulation of DNA binding; lung alveolus development; digestive tract development; positive regulation of smooth muscle contraction; cardiocyte differentiation; ductus arteriosus closure; positive regulation of transcription by RNA polymerase II; negative regulation of cell population proliferation; regulation of smooth muscle cell differentiation; transcription by RNA polymerase II; cardiac muscle cell differentiation; positive regulation of gene expression; negative regulation of vascular associated smooth muscle cell proliferation; negative regulation of vascular associated smooth muscle cell migration; negative regulation of platelet-derived growth factor receptor-beta signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	93649
	214384
	ENSG00000141052
	ENSMUSG00000020542
	Q8IZQ8
	Q8VIM5
	NM_001146312; NM_001146313; NM_153604; NM_001378306
	NM_145136; NM_146386
	NP_001139784; NP_705832; NP_001365235
	NP_660118; NP_666498
	Wikidata
View/Edit Human	View/Edit Mouse

Myocardin is a protein that in humans is encoded by the MYOCD gene.^[5]^[6]^[7]

Myocardin is a smooth muscle and cardiac muscle-specific transcriptional coactivator of serum response factor. When expressed ectopically in nonmuscle cells, myocardin can induce smooth muscle differentiation by its association with serum response factor (SRF; MIM 600589).[supplied by OMIM]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000141052 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020542 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wang D, Chang PS, Wang Z, Sutherland L, Richardson JA, Small E, Krieg PA, Olson EN (Jul 2001). "Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor". Cell. 105 (7): 851–62. doi:10.1016/S0092-8674(01)00404-4. PMID 11439182. S2CID 3762021.
^ Wang DZ, Li S, Hockemeyer D, Sutherland L, Wang Z, Schratt G, Richardson JA, Nordheim A, Olson EN (Nov 2002). "Potentiation of serum response factor activity by a family of myocardin-related transcription factors". Proc Natl Acad Sci U S A. 99 (23): 14855–60. Bibcode:2002PNAS...9914855W. doi:10.1073/pnas.222561499. PMC 137508. PMID 12397177.
^ ^a ^b "Entrez Gene: MYOCD myocardin".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000141052 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020542 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11439182-5] Wang D, Chang PS, Wang Z, Sutherland L, Richardson JA, Small E, Krieg PA, Olson EN (Jul 2001). "Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor". Cell. 105 (7): 851–62. doi:10.1016/S0092-8674(01)00404-4. PMID 11439182. S2CID 3762021.

[pmid12397177-6] Wang DZ, Li S, Hockemeyer D, Sutherland L, Wang Z, Schratt G, Richardson JA, Nordheim A, Olson EN (Nov 2002). "Potentiation of serum response factor activity by a family of myocardin-related transcription factors". Proc Natl Acad Sci U S A. 99 (23): 14855–60. Bibcode:2002PNAS...9914855W. doi:10.1073/pnas.222561499. PMC 137508. PMID 12397177.

[entrez-7] "Entrez Gene: MYOCD myocardin".

Myocardin information

and 11 Related for: Myocardin information

Myocardin

MKL2

MKL1

Chromosome 16

Haemodynamic response

Mef2

KLF15

Eomesodermin

Serum response factor

HEY2

Telokin