Closely related bacterium species that cause tuberculosis
The Mycobacterium tuberculosis complex (MTC or MTBC) is a genetically related group of Mycobacterium species that can cause tuberculosis in humans or other animals.
It includes:
Mycobacterium tuberculosis
Mycobacterium africanum
Mycobacterium orygis[1]
Mycobacterium bovis and the Bacillus Calmette–Guérin strain
Mycobacterium microti
Mycobacterium canettii
Mycobacterium caprae
Mycobacterium pinnipedii
Mycobacterium suricattae[2]
Mycobacterium mungi[3]
In addition, two branches exist which have phylogenetic similarities but are not completely described: the dassie and oryx bacilli. Oryx bacilli has been recently reclassified into a separate subspecies, orygis.[1]
Members of the MTC can be distinguished from all other bacteria by the presence of 63 conserved signature indels (CSIs) present in diverse proteins that are exclusively shared by these pathogens.[4] Due to their exclusivity for the MTC complex and presence in highly conserved regions of proteins, these CSIs provide novel means for functional and diagnostic studies (including potential targets for development of novel therapeutics).[4]
Since 2018, all members of this species complex are considered synonyms of M. tuberculosis as far as bacterial nomenclature is concerned. The IJSEM article reports that M. africanum, M. bovis, M. caprae, M. pinnipedii are 99.21–99.92% identical to M. tuberculosis on the whole-genome level, failing the criteria to be considered independent species. The same applies to "M. canetti", "M. mungi", and "M. orygis", species not validly published. The variation is even below the accepted level for subspecies. Authors of the article note that these names do refer to stable lineages with meaningful clinical distinctions, recommending that them become variants: M. bovis would become M. tuberculosis var. bovis, for example.[5]
^ abvan Ingen J, Rahim Z, Mulder A, Boeree MJ, Simeone R, Brosch R, van Soolingen D (April 2012). "Characterization of Mycobacterium orygis as M. tuberculosis complex subspecies". Emerging Infectious Diseases. 18 (4): 653–5. doi:10.3201/eid1804.110888. PMC 3309669. PMID 22469053.
^Patterson, S, Drewe, JA, Pfeiffer, DU, Clutton-Brock, TH (2017). "Social and environmental factors affect tuberculosis related mortality in wild meerkats". Journal of Animal Ecology. 86 (3): 442–450. Bibcode:2017JAnEc..86..442P. doi:10.1111/1365-2656.12649. PMC 5413830. PMID 28186336.
^Vasconcellos SE, Huard RC, Niemann S, Kremer K, Santos AR, Suffys PN, Ho JL (March 2010). "Distinct genotypic profiles of the two major clades of Mycobacterium africanum". BMC Infectious Diseases. 10: 80. doi:10.1186/1471-2334-10-80. PMC 2859774. PMID 20350321.
^ abGupta, Radhey S. (2018-10-02). "Impact of Genomics on Clarifying the Evolutionary Relationships amongst Mycobacteria: Identification of Molecular Signatures Specific for the Tuberculosis-Complex of Bacteria with Potential Applications for Novel Diagnostics and Therapeutics". High-Throughput. 7 (4): 31. doi:10.3390/ht7040031. ISSN 2571-5135. PMC 6306742. PMID 30279355.
^Riojas, Marco A.; McGough, Katya J.; Rider-Riojas, Cristin J.; Rastogi, Nalin; Hazbón, Manzour Hernando (1 January 2018). "Phylogenomic analysis of the species of the Mycobacterium tuberculosis complex demonstrates that Mycobacterium africanum, Mycobacterium bovis, Mycobacterium caprae, Mycobacterium microti and Mycobacterium pinnipedii are later heterotypic synonyms of Mycobacterium tuberculosis". International Journal of Systematic and Evolutionary Microbiology. 68 (1): 324–332. doi:10.1099/ijsem.0.002507. PMID 29205127.
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