A mode of toxic action is a common set of physiological and behavioral signs that characterize a type of adverse biological response.[1] A mode of action should not be confused with mechanism of action, which refer to the biochemical processes underlying a given mode of action.[2] Modes of toxic action are important, widely used tools in ecotoxicology and aquatic toxicology because they classify toxicants or pollutants according to their type of toxic action. There are two major types of modes of toxic action: non-specific acting toxicants and specific acting toxicants. Non-specific acting toxicants are those that produce narcosis, while specific acting toxicants are those that are non-narcotic and that produce a specific action at a specific target site.
^Rand G (1995). Fundamentals of Aquatic Toxicology: Effects, Environmental Fate, and Risk Assessment. Boca Raton, FL: CRC Press. ISBN 1-56032-091-5.
^Escher BI, Hermens JL (October 2002). "Modes of action in ecotoxicology: their role in body burdens, species sensitivity, QSARs, and mixture effects". Environ. Sci. Technol. 36 (20): 4201–17. Bibcode:2002EnST...36.4201E. doi:10.1021/es015848h. PMID 12387389.
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confused with mechanism ofaction, which refer to the biochemical processes underlying a given modeofaction. Modesoftoxicaction are important, widely...
15% COHb, meaning toxicity is consistently observed at levels in excess of this concentration. The FDA has previously set a threshold of 14% COHb in certain...
modesofaction can be separated into specific FATS. Overall, FATS aid QSAR models by providing a systematic way of defining and predicting modesof action...
; Eggen, Rik I. L. (2001). "Chemical properties of catechols and their molecular modesoftoxicaction in cells, from microorganisms to mammals. Minireview"...
protein, biochemical methods can be used to determine the toxicity, efficacy, and mechanism ofactionof the drug. Typically, computation inference methods are...
provides another way of classifying insecticides. Modeofaction can be important in understanding whether an insecticide will be toxic to unrelated species...
of the species with confirmed resistance to the largest number of herbicide modesofaction, both with confirmed resistance to 12 different modesof action;...
plants commonly used as food possess toxic parts, are toxic unless processed, or are toxic at certain stages of their lives. Some only pose a serious...
Biochemical ModeofAction, Biological Activity and Agricultural Importance". In Ishaaya I, Degheele D (eds.). Insecticides with Novel ModesofAction: Mechanisms...
selectively controls broad-leaf weeds in pasture and cereal crops. The modeofactionof MCPA is as an auxin, which are growth hormones that naturally exist...
Environmental Protection Agency considers oil of citronella as a biopesticide with a non-toxicmodeofaction. Citronella oil has strong antifungal properties...
most other organophosphates, its modeofaction is via cholinesterase inhibition. Due to its relatively low toxicity towards humans and mammals, fenthion...
modesofaction, along with cultural methods such as crop rotation, in integrated weed management (IWM) systems. Paraquat, with its distinctive mode of...
different modesofaction gives actual or almost 100% eradications of the rodent population in the area, if the acceptance/palatability of baits are good...
Chromium toxicity refers to any poisonous toxic effect in an organism or cell that results from exposure to specific forms of chromium—especially hexavalent...
identify which kind of additivity is being used. These effects reflect the underlying modesofaction and mechanisms oftoxicityof the chemicals. Additivity...
Che CM (April 2006). "Proteomic analysis of the modeof antibacterial actionof silver nanoparticles". Journal of Proteome Research. 5 (4): 916–24. doi:10...
water. Spinosad is a novel mode-of-action insecticide derived from a family of natural products obtained by fermentation of S. spinosa. Spinosyns occur...
Fortnite client to present Epic's own various modes as well as the numerous creative modes as part of Fortnite Experiences, comparable to Roblox in presentation...
advent of nuclear physics and nuclear technologies—are radiological poisons. These are associated with ionizing radiation, a modeoftoxicity quite distinct...
also described toxic actionof rotenone at low concentrations (5 nM) in dopaminergic neurons from acute rat brain slices. This toxicity was exacerbated by...
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