The missing heritability problem[1][2][3][4][5][6] refers to the difference between heritability estimates from genetic data and heritability estimates from twin and family data across many physical and mental traits, including diseases, behaviors, and other phenotypes. This is a problem that has significant implications for medicine, since a person's susceptibility to disease may depend more on the combined effect of all the genes in the background than on the disease genes in the foreground, or the role of genes may have been severely overestimated.
^Manolio, T. A.; Collins, F. S.; Cox, N. J.; Goldstein, D. B.; Hindorff, L. A.; Hunter, D. J.; McCarthy, M. I.; Ramos, E. M.; Cardon, L. R.; Chakravarti, A.; Cho, J. H.; Guttmacher, A. E.; Kong, A.; Kruglyak, L.; Mardis, E.; Rotimi, C. N.; Slatkin, M.; Valle, D.; Whittemore, A. S.; Boehnke, M.; Clark, A. G.; Eichler, E. E.; Gibson, G.; Haines, J. L.; MacKay, T. F. C.; McCarroll, S. A.; Visscher, P. M. (2009). "Finding the missing heritability of complex diseases". Nature. 461 (7265): 747–753. Bibcode:2009Natur.461..747M. doi:10.1038/nature08494. PMC 2831613. PMID 19812666.
^Zuk, O.; Hechter, E.; Sunyaev, S. R.; Lander, E. S. (2012). "The mystery of missing heritability: Genetic interactions create phantom heritability". Proceedings of the National Academy of Sciences. 109 (4): 1193–1198. Bibcode:2012PNAS..109.1193Z. doi:10.1073/pnas.1119675109. PMC 3268279. PMID 22223662.
^Lee, S. H.; Wray, N. R.; Goddard, M. E.; Visscher, P. M. (2011). "Estimating Missing Heritability for Disease from Genome-wide Association Studies". American Journal of Human Genetics. 88 (3): 294–305. doi:10.1016/j.ajhg.2011.02.002. PMC 3059431. PMID 21376301.
^Slatkin, M. (2009). "Epigenetic Inheritance and the Missing Heritability Problem". Genetics. 182 (3): 845–850. doi:10.1534/genetics.109.102798. PMC 2710163. PMID 19416939.
^Eichler, E. E.; Flint, J.; Gibson, G.; Kong, A.; Leal, S. M.; Moore, J. H.; Nadeau, J. H. (2010). "Missing heritability and strategies for finding the underlying causes of complex disease". Nature Reviews Genetics. 11 (6): 446–450. doi:10.1038/nrg2809. PMC 2942068. PMID 20479774.
^"Personal genomes: The case of the missing heritability", Maher 2008, Nature.
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The missingheritabilityproblem refers to the difference between heritability estimates from genetic data and heritability estimates from twin and family...
Lander ES (January 2012). "The mystery of missingheritability: Genetic interactions create phantom heritability". Proceedings of the National Academy of...
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adult individuals have found a heritability of IQ between 57% and 73%, with some recent studies showing heritability for IQ as high as 80%. IQ goes from...
organism's genes contribute to a complex trait is called heritability. Measurement of the heritability of a trait is relative—in a more variable environment...
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The heritability of autism is the proportion of differences in expression of autism that can be explained by genetic variation; if the heritability of...
particular properties in a small proportion of their progeny. Though heritability and variations in bacteria had been noticed from the early days of bacteriology...
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California, Berkeley (7 February 2005). "UC Berkeley, French Scientists Find Missing Link Between The Whale And Its Closest Relative, The Hippo". Retrieved...
approaches to depression Genetic genealogy Heritability of IQ Human mating strategies Missingheritabilityproblem Race and genetics Sexual selection in humans...
sources of variance. However, understanding the concept of heritability can be tricky – heritability refers only to the differences between people, never the...
not even survive past fertilization. In plants however this is less of a problem. Polyploid individuals are created frequently by a variety of processes;...
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has been found – this is known as the missingheritabilityproblem, which ADHD shares with many other heritable human traits such as schizophrenia. In...
explains why wheels are an unlikely solution to the problem of locomotion: a partially evolved wheel, missing one or more key features, would probably not impart...
classified by their shape. Bacterial genetics studies the mechanisms of their heritable information, their chromosomes, plasmids, transposons, and phages. Gene...
"instinct blindness" makes the study of psychology difficult. To get past this problem, James suggested that we try to make the "natural seem strange": It takes...
emerging genomic estimates of heritability of obesity and Type 2 diabetes, sometimes called the "missingheritabilityproblem." The reasons for this discrepancy...
evolutionary psychologists to use the theory of evolution to shed light on the problem of mood disorders within the perspective of evolutionary psychiatry. Depression...
and can even cause premature birth. Malnutrition in children is a huge problem in developing countries. Rising global temperatures can alter growing seasons...
received an NSF grant to continue his work on the so-called "missingheritability" problem. His whale lice work had already shown that a genome should...
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