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Mersalyl information


Mersalyl
Names
IUPAC name
(3-{[2-(Carboxymethoxy)benzoyl]amino}-2-methoxypropyl)(hydroxy)mercury
Other names
Mersalyl acid, salyrganic acid
Identifiers
CAS Number
  • 486-67-9 checkY
3D model (JSmol)
  • Interactive image
ChEMBL
  • ChEMBL1201330 ☒N
ChemSpider
  • 11337655 checkY
ECHA InfoCard 100.006.943 Edit this at Wikidata
IUPHAR/BPS
  • 5331
PubChem CID
  • 443130
UNII
  • 7RDI07K19U checkY
CompTox Dashboard (EPA)
  • DTXSID101334269 DTXSID3046902, DTXSID101334269 Edit this at Wikidata
InChI
  • InChI=1S/C13H16NO5.Hg.H2O/c1-9(18-2)7-14-13(17)10-5-3-4-6-11(10)19-8-12(15)16;;/h3-6,9H,1,7-8H2,2H3,(H,14,17)(H,15,16);;1H2/q;+1;/p-1 checkY
    Key: HQRSUIDICNOLPX-UHFFFAOYSA-M checkY
  • InChI=1/C13H16NO5.Hg.H2O/c1-9(18-2)7-14-13(17)10-5-3-4-6-11(10)19-8-12(15)16;;/h3-6,9H,1,7-8H2,2H3,(H,14,17)(H,15,16);;1H2/q;+1;/p-1/rC13H17HgNO6/c1-20-9(6-14-19)7-15-13(18)10-4-2-3-5-11(10)21-8-12(16)17/h2-5,9,19H,6-8H2,1H3,(H,15,18)(H,16,17)
    Key: HQRSUIDICNOLPX-SCJHNVIKAK
SMILES
  • O[Hg]CC(OC)CNC(=O)c1ccccc1OCC(O)=O
Properties
Chemical formula
 C13H18HgNO6
Molar mass 484.87512 g/mol
Pharmacology
ATC code
 C03BC01 (WHO)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Mersalyl (Mersal) is an organomercury compound[1] and mercurial diuretic. It is only rarely used as a drug, having been superseded by thiazides and loop diuretics that are less toxic because they do not contain mercury. It features a Hg(II) centre. Mersalyl was originally adapted from calomel (Hg2Cl2), a diuretic discovered by Paracelsus.

  1. ^ Stewart, J. H.; Edwards, K. D. (1965). "Clinical comparison of frusemide with bendrofluazide, mersalyl, and ethacrynic acid". British Medical Journal. 2 (5473): 1277–1281. doi:10.1136/bmj.2.5473.1277. PMC 1846704. PMID 5849145.

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Mersalyl

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Mersalyl (Mersal) is an organomercury compound and mercurial diuretic. It is only rarely used as a drug, having been superseded by thiazides and loop diuretics...

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ATC code C03

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C03BB05 Mefruside and potassium C03BB07 Clofenamide and potassium C03BC01 Mersalyl C03BD01 Theobromine C03BX03 Cicletanine C03CA01 Furosemide C03CA02 Bumetanide...

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Mercurial diuretic

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adults. Some common organic mercurials: Chlormerodrin Merbaphen (Novasurol) Mersalyl acid (Mersal, Salyrgan) Meralluride Mercaptomerin Mercurophylline Merethoxylline...

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Organomercury chemistry

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ethylmercury chloride and phenylmercury acetate. Mercurial diuretics such as mersalyl acid were once in common use, but have been superseded by the thiazides...

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Adenine nucleotide translocator

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mediate H+ transport by free fatty acids, which is further stimulated by mersalyl". The Journal of Biological Chemistry. 269 (44): 27329–36. doi:10...

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Mitochondrial permeability transition pore

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of an Insensitive Cyclosporin a Non-specific Pore by Phenylarsine Plus Mersalyl". Cell Biochemistry and Biophysics. 49 (2): 84–90. doi:10.1007/s12013-007-0047-0...

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Jennifer Moyle

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lanthanide-sensitive (Ca2)4+--HPO42- symporter that is insensitive to NEM and mersalyl catalyzed calcium translocation in the mitochondria of the rat liver. Jennifer...

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Mitochondrial dicarboxylate carrier

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butylmalonate, as well as bathophenanthroline and thiol reagents such as Mersalyl and p-hydroxymercuribenzoate. The activity of dicarboxylate carriers has...

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