MTA1 information

MTA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4BKX, 4PBY, 4PBZ, 4PC0, 5ICN, 5FXY
Identifiers
Aliases	MTA1, metastasis associated 1
External IDs	OMIM: 603526 MGI: 2150037 HomoloGene: 3442 GeneCards: MTA1
Gene location (Human)
Chr.	Chromosome 14 (human)
End	105,470,729 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	113,100,826 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; left uterine tube; ; canal of the cervix; ; anterior pituitary; ; tibial nerve; ; ganglionic eminence; ; gastric mucosa; ; minor salivary glands;
	Top expressed in
	somite; ; molar; ; maxillary prominence; ; yolk sac; ; hand; ; atrium; ; abdominal wall; ; ganglionic eminence; ; thymus; ; lip;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; transcription corepressor activity; DNA-binding transcription factor activity; transcription coactivator activity; zinc ion binding; chromatin binding; metal ion binding; core promoter sequence-specific DNA binding; protein binding; histone deacetylase activity; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; histone deacetylase binding;
Cellular component	cytoplasm; nuclear envelope; intracellular membrane-bounded organelle; nucleoplasm; microtubule; cytoskeleton; nucleus; cytosol; NuRD complex;
Biological process	response to ionizing radiation; regulation of transcription, DNA-templated; regulation of gene expression, epigenetic; rhythmic process; circadian regulation of gene expression; transcription, DNA-templated; positive regulation of protein autoubiquitination; double-strand break repair; entrainment of circadian clock by photoperiod; signal transduction; proteasome-mediated ubiquitin-dependent protein catabolic process; locomotor rhythm; histone deacetylation; negative regulation of nucleic acid-templated transcription; regulation of transcription by RNA polymerase II; positive regulation of nucleic acid-templated transcription; negative regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	9112
	116870
	ENSG00000182979
	ENSMUSG00000021144
	Q13330
	Q8K4B0
	NM_001203258; NM_004689
NM_054081; NM_001346696; NM_001364620; NM_001364621; NM_001364622;
	NM_001364623
	NP_001190187; NP_004680
NP_001333625; NP_473422; NP_001351549; NP_001351550; NP_001351551;
	NP_001351552
	Wikidata
View/Edit Human	View/Edit Mouse

Metastasis-associated protein MTA1 is a protein that in humans is encoded by the MTA1 gene. MTA1 is the founding member of the MTA family of genes.^[5]^[6] MTA1 is primarily localized in the nucleus but also found to be distributed in the extra-nuclear compartments.^[7] MTA1 is a component of several chromatin remodeling complexes including the nucleosome remodeling and deacetylation complex (NuRD).^[8]^[9] MTA1 regulates gene expression by functioning as a coregulator to integrate DNA-interacting factors to gene activity.^[10] MTA1 participates in physiological functions in the normal and cancer cells.^[11]^[12] MTA1 is one of the most upregulated proteins in human cancer and associates with cancer progression, aggressive phenotypes, and poor prognosis of cancer patients.^[9]^[13]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000182979 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021144 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Toh Y, Pencil SD, Nicolson GL (Sep 1994). "A novel candidate metastasis-associated gene, mta1, differentially expressed in highly metastatic mammary adenocarcinoma cell lines. cDNA cloning, expression, and protein analyses". The Journal of Biological Chemistry. 269 (37): 22958–63. doi:10.1016/S0021-9258(17)31603-4. PMID 8083195.
^ Toh Y, Nicolson GL (Dec 2014). "Properties and clinical relevance of MTA1 protein in human cancer". Cancer and Metastasis Reviews. 33 (4): 891–900. doi:10.1007/s10555-014-9516-2. PMID 25359582. S2CID 17852701.
^ Liu J, Wang H, Huang C, Qian H (Dec 2014). "Subcellular localization of MTA proteins in normal and cancer cells". Cancer and Metastasis Reviews. 33 (4): 843–56. doi:10.1007/s10555-014-9511-7. PMID 25398252. S2CID 7959609.
^ Xue Y, Wong J, Moreno GT, Young MK, Côté J, Wang W (Dec 1998). "NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities". Molecular Cell. 2 (6): 851–61. doi:10.1016/s1097-2765(00)80299-3. PMID 9885572.
^ ^a ^b Li DQ, Kumar R (2015). "Unravelling the Complexity and Functions of MTA Coregulators in Human Cancer". Advances in Cancer Research. Vol. 127. pp. 1–47. doi:10.1016/bs.acr.2015.04.005. ISBN 9780128029206. PMID 26093897.
^ Kumar R, Gururaj AE (2008). "Coregulators as Oncogenes and Tumor Suppressors". In O'Malley BW, Kumar R (eds.). Nuclear Receptor Coregulators and Human Diseases. Hackensack, N.J.: World Scientific. pp. 195–218. doi:10.1142/9789812819178_0004. ISBN 978-981-281-917-8.
^ Sen N, Gui B, Kumar R (Dec 2014). "Physiological functions of MTA family of proteins". Cancer and Metastasis Reviews. 33 (4): 869–77. doi:10.1007/s10555-014-9514-4. PMC 4245464. PMID 25344801.
^ Sen N, Gui B, Kumar R (Dec 2014). "Role of MTA1 in cancer progression and metastasis". Cancer and Metastasis Reviews. 33 (4): 879–89. doi:10.1007/s10555-014-9515-3. PMC 4245458. PMID 25344802.
^ Kumar R (Dec 2014). "Functions and clinical relevance of MTA proteins in human cancer. Preface". Cancer and Metastasis Reviews. 33 (4): 835. doi:10.1007/s10555-014-9509-1. PMC 4245326. PMID 25348751.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000182979 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021144 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[1-Toh-5] Toh Y, Pencil SD, Nicolson GL (Sep 1994). "A novel candidate metastasis-associated gene, mta1, differentially expressed in highly metastatic mammary adenocarcinoma cell lines. cDNA cloning, expression, and protein analyses". The Journal of Biological Chemistry. 269 (37): 22958–63. doi:10.1016/S0021-9258(17)31603-4. PMID 8083195.

[2-toh-6] Toh Y, Nicolson GL (Dec 2014). "Properties and clinical relevance of MTA1 protein in human cancer". Cancer and Metastasis Reviews. 33 (4): 891–900. doi:10.1007/s10555-014-9516-2. PMID 25359582. S2CID 17852701.

[4-Liu-7] Liu J, Wang H, Huang C, Qian H (Dec 2014). "Subcellular localization of MTA proteins in normal and cancer cells". Cancer and Metastasis Reviews. 33 (4): 843–56. doi:10.1007/s10555-014-9511-7. PMID 25398252. S2CID 7959609.

[5-xue-8] Xue Y, Wong J, Moreno GT, Young MK, Côté J, Wang W (Dec 1998). "NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities". Molecular Cell. 2 (6): 851–61. doi:10.1016/s1097-2765(00)80299-3. PMID 9885572.

[6-Li-9] Li DQ, Kumar R (2015). "Unravelling the Complexity and Functions of MTA Coregulators in Human Cancer". Advances in Cancer Research. Vol. 127. pp. 1–47. doi:10.1016/bs.acr.2015.04.005. ISBN 9780128029206. PMID 26093897.

[7-Kumar-10] Kumar R, Gururaj AE (2008). "Coregulators as Oncogenes and Tumor Suppressors". In O'Malley BW, Kumar R (eds.). Nuclear Receptor Coregulators and Human Diseases. Hackensack, N.J.: World Scientific. pp. 195–218. doi:10.1142/9789812819178_0004. ISBN 978-981-281-917-8.

[8-sen-11] Sen N, Gui B, Kumar R (Dec 2014). "Physiological functions of MTA family of proteins". Cancer and Metastasis Reviews. 33 (4): 869–77. doi:10.1007/s10555-014-9514-4. PMC 4245464. PMID 25344801.

[9-sen-12] Sen N, Gui B, Kumar R (Dec 2014). "Role of MTA1 in cancer progression and metastasis". Cancer and Metastasis Reviews. 33 (4): 879–89. doi:10.1007/s10555-014-9515-3. PMC 4245458. PMID 25344802.

[10-kumar-13] Kumar R (Dec 2014). "Functions and clinical relevance of MTA proteins in human cancer. Preface". Cancer and Metastasis Reviews. 33 (4): 835. doi:10.1007/s10555-014-9509-1. PMC 4245326. PMID 25348751.

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