Protein-coding gene in the species Homo sapiens
EHMT1 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IGQ, 2RFI, 3B7B, 3B95, 3FPD, 3HNA, 3MO0, 3MO2, 3MO5, 3SW9, 3SWC, 4I51
Identifiers Aliases EHMT1 , EUHMTASE1, Eu-HMTase1, FP13812, GLP, GLP1, KMT1D, bA188C12.1, euchromatic histone lysine methyltransferase 1, EHMT1-IT1, KLEFS1External IDs OMIM: 607001; MGI: 1924933; HomoloGene: 11698; GeneCards: EHMT1; OMA:EHMT1 - orthologs Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.3 Start 137,618,992 bp[1] End 137,870,016 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A3 Start 24,789,928 bp[2] End 24,919,614 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve skin of abdomen right lobe of thyroid gland left lobe of thyroid gland canal of the cervix gastric mucosa spleen minor salivary glands transverse colon right lung
Top expressed in hand superior cervical ganglion otolith organ utricle maxillary prominence foot ganglionic eminence medial ganglionic eminence medullary collecting duct renal corpuscle
More reference expression data
BioGPS
Gene ontology Molecular function
methyltransferase activity
transferase activity
histone methyltransferase activity (H3-K9 specific)
zinc ion binding
C2H2 zinc finger domain binding
histone-lysine N-methyltransferase activity
metal ion binding
histone methyltransferase activity (H3-K27 specific)
protein-lysine N-methyltransferase activity
protein binding
p53 binding
Cellular component
nucleoplasm
chromosome
nucleus
nuclear body
Biological process
response to fungicide
embryo development
negative regulation of transcription by RNA polymerase II
peptidyl-lysine monomethylation
histone H3-K27 methylation
DNA methylation
methylation
histone H3-K9 methylation
peptidyl-lysine dimethylation
histone lysine methylation
histone methylation
negative regulation of transcription, DNA-templated
negative regulation of G0 to G1 transition
chromatin organization
regulation of embryonic development
positive regulation of cold-induced thermogenesis
regulation of signal transduction by p53 class mediator
Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) NM_001145527 NM_024757 NM_001039765 NM_001354259 NM_001354263 NM_001354611 NM_001354612
NM_001012518 NM_001109686 NM_001109687 NM_172545
RefSeq (protein) NP_001138999 NP_079033 NP_001341188 NP_001341192 NP_001341540 NP_001341541
NP_001012536 NP_001103156 NP_001103157 NP_766133
Location (UCSC) Chr 9: 137.62 – 137.87 Mb Chr 2: 24.79 – 24.92 Mb PubMed search [3] [4]
Wikidata View/Edit Human View/Edit Mouse
Euchromatic histone-lysine N-methyltransferase 1 , also known as G9a-like protein (GLP ), is a protein that in humans is encoded by the EHMT1 gene.[5]
^ a b c GRCh38: Ensembl release 89: ENSG00000181090 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036893 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Entrez Gene: Euchromatic histone-lysine N-methyltransferase 1". Retrieved 2012-03-04 .
Last Update: 2024-02-21T14:47:05Z
G9a-like protein (GLP), is a protein that in humans is encoded by the EHMT1 gene. EHMT1 messenger RNA is alternatively spliced to produce three predicted...
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Last Update: 2024-04-04T12:18:27Z
encoding proteins with histone methyltransferase activity include: ASH1L DOT1L EHMT1 , EHMT2, EZH1, EZH2 MLL, MLL2, MLL3, MLL4, MLL5 NSD1 PRDM2 SET, SETBP1, SETD1A...
Word Count : 2214
Last Update: 2023-12-01T19:22:59Z
CTTNBP2; DAPK1; DDEF1; DDEF2; DDEFL1; DGKI; DGKZ; DP58; DYSFIP1; DZANK; EHMT1 ; EHMT2; ESPN; FANK1; FEM1A; FEM1B; GABPB2; GIT1; GIT2; GLS; GLS2; HACE1;...
Word Count : 1393
Last Update: 2022-02-13T18:25:35Z
this domain include: ASH1L, also has an associated with SET domain (AWS) EHMT1 (FP13812), EHMT2 (BAT8), EZH1, EZH2 MLL, MLL2, MLL3, MLL5 NSD1 PRDM1, PRDM2...
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Last Update: 2022-06-23T09:41:35Z
HG, Veltman JA, Schenck A, van Bokhoven H (July 2012). "Disruption of an EHMT1 -associated chromatin-modification module causes intellectual disability"...
Word Count : 1221
Last Update: 2024-05-09T15:43:25Z
245150; MGP Kindler syndrome; 173650; KIND1 Kleefstra syndrome; 610253; EHMT1 Klippel–Feil syndrome, autosomal dominant; 118100; GDF6 Kniest dysplasia;...
Word Count : 18877