MHETase ribbon diagram (PDB: 6QGA). The hydrolase domain is shown in brown including the catalytic rsidues in magenta. The lid domain is shown in blue. The substrate analogue monohydroxyethylterphthalamide is shown in green.
The enzyme MHETase is a hydrolase, which was discovered in 2016. It cleaves 2-hydroxyethyl terephthalic acid, the PET degradation product by PETase, to ethylene glycol and terephthalic acid.[1] This pair of enzymes, PETase and MHETase, enable the bacterium Ideonella sakaiensis to live on the plastic PET as sole carbon source.
^Yoshida S, Hiraga K, Takehana T, Taniguchi I, Yamaji H, Maeda Y, et al. (March 2016). "A bacterium that degrades and assimilates poly(ethylene terephthalate)". Science. 351 (6278): 1196–9. doi:10.1126/science.aad6359. PMID 26965627.
The enzyme MHETase is a hydrolase, which was discovered in 2016. It cleaves 2-hydroxyethyl terephthalic acid, the PET degradation product by PETase, to...
two monomeric constituents by a lipid-anchored MHET hydrolase enzyme, or MHETase, on the cell's outer membrane. The overall mechanism of the PET plastic...
of MHETase enzyme to terephthalic acid and ethylene glycol. Laboratory experiments showed that chimeric proteins that artificially link a MHETase and...
such as hydrolases and cutinases. Following the activity of enzymes like MHETase, molecules from PET degradation are taken up by active transport into bacterial...
description of synergistic enzymes – PETase, first discovered in 2016, and MHETase of Ideonella sakaiensis – for faster depolymerization of PET as well as...
the bacterium, PETase, has been genetically modified and combined with MHETase to break down PET faster, and also degrade PEF. In 2021, researchers reported...
description of synergistic enzymes – PETase, first discovered in 2016, and MHETase of Ideonella sakaiensis – for faster depolymerization of PET and also of...
description of synergistic enzymes – PETase, first discovered in 2016, and MHETase of Ideonella sakaiensis – for faster depolymerization of PET and also of...
a low-grade PET film, the bacteria used two novel enzymes, PETase and MHETase, to decompose the plastic into two environmentally benign substances, which...
description of synergistic enzymes – PETase, first discovered in 2016, and MHETase of Ideonella sakaiensis – for faster depolymerization of PET as well as...
Global Information