cellular response to phorbol 13-acetate 12-myristate
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
11184
26411
Ensembl
ENSG00000282928 ENSG00000104814
ENSMUSG00000037337
UniProt
Q92918
P70218
RefSeq (mRNA)
NM_001042600 NM_007181
NM_008279 NM_001355054
RefSeq (protein)
NP_001036065 NP_009112
NP_032305 NP_001341983
Location (UCSC)
Chr 19: 38.59 – 38.62 Mb
Chr 7: 28.68 – 28.7 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Mitogen-activated protein kinase kinase kinase kinase 1 is a protein kinase that in humans is encoded by the MAP4K1 gene.[5] It is also known as HPK1 (Hematopoietic Progenitor Kinase 1). The protein has been shown to play a role in JNK activation.[6]
^ abcGRCm38: Ensembl release 89: ENSMUSG00000037337 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Hu MC, Qiu WR, Wang X, Meyer CF, Tan TH (Dec 1996). "Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade". Genes Dev. 10 (18): 2251–64. doi:10.1101/gad.10.18.2251. PMID 8824585.
^Chuang HC, Wang X, Tan TH (2016). MAP4K Family Kinases in Immunity and Inflammation. Advances in Immunology. Vol. 129. pp. 277–314. doi:10.1016/bs.ai.2015.09.006. ISBN 9780128047996. PMID 26791862. {{cite book}}: |journal= ignored (help)
the MAP4K1 gene. It is also known as HPK1 (Hematopoietic Progenitor Kinase 1). The protein has been shown to play a role in JNK activation. MAP4K1 has...
(MAP4K) is a family of proteins involved in cellular signal transduction. MAP4K1 (aka HPK1) MAP4K2 (aka GCK) MAP4K3 (aka GLK) MAP4K4 (aka HGK) MAP4K5 (aka...
becomes active. Misshapen (Msn, MAP4K4/6/7 in mammals) and Happyhour (Hppy, MAP4K1/2/3/5 in mammals) act in parallel to Hpo to activate Wts. Wts is a nuclear...
Activation of T cells has been shown to interact with: GRAP2, GRAP, Grb2, ITK, MAP4K1 PIK3R1, PLCG1, SHB, VAV1, and ZAP-70. GRCh38: Ensembl release 89: ENSG00000213658...