May 22, 2015; 8 years ago (2015-05-22) in Raleigh, NC, USA
Founders
Paul Garofolo[1][2]
Nick Taylor
Dave Ousterout
Rodolphe Barrangou[3]
Charles Gersbach
Chase Beisel
Ahmed Gomaa
Headquarters
Morrisville, North Carolina
,
United States
Brands
crPhage
Number of employees
80[4] (2021)
Website
www.locus-bio.com
Locus Biosciences is a clinical-stage pharmaceutical company, founded in 2015 and based in Research Triangle Park, North Carolina.[2] Locus develops phage therapies based on CRISPR–Cas3 gene editing technology, as opposed to the more commonly used CRISPR-Cas9, delivered by engineered bacteriophages.[5] The intended therapeutic targets are antibiotic-resistant bacterial infections.[1][5]
^ abBuhr, Sarah (December 21, 2018). "Move over Cas9, CRISPR-Cas3 might hold the key to solving the antibiotics crisis". TechCrunch. Archived from the original on February 20, 2019. Retrieved July 18, 2020.
^ abEanes, Zachery (March 9, 2021). "Locus using gene-editing technology to get ahead of drug-resistant bacteria". The Herald-Sun. pp. B4. Retrieved August 19, 2022 – via Newspapers.com.
^Barrangou, R. (2019). "CRISPR on the Move in 2019". The CRISPR Journal. 2. Affiliations. doi:10.1089/crispr.2019.29043.rba. PMID 31021232. S2CID 92382436. Retrieved August 19, 2022.
^Cite error: The named reference Eanes2022 was invoked but never defined (see the help page).
^ abGibney, Elizabeth (January 2, 2018). "What to expect in 2018: science in the new year". Nature. 553 (7686): 12–13. Bibcode:2018Natur.553...12G. doi:10.1038/d41586-018-00009-5. PMID 29300040.
LocusBiosciences is a clinical-stage pharmaceutical company, founded in 2015 and based in Research Triangle Park, North Carolina. Locus develops phage...
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Belgium in 2015–17, was terminated early due to lack of effectiveness. LocusBiosciences has created a cocktail of three CRISPR-modified phages. A 2019 study...
one, or a small number of alleles exist for each gene. In any one gene locus a dog will either be homozygous where the gene is made of two identical...
Agouti. The E locus also determines whether the phenotype due to the third genetic locus affecting coat colour will be evident. This locus is recognised...
Koltzoff (Koltsov) de lier génétique, embryologie et chimie physique, J. Biosciences. 2011. V. 36. P. 211-214 Waddington CH (1942). "The epigenotype". Endeavour...
The discovery of an immune system in prokaryotes" (PDF). Journal of Biosciences. 40 (2): 221–223. doi:10.1007/s12038-015-9532-6. PMID 25963251. Lander...
one allele occupies that gene's locus within a population. In addition to having more than one allele at a specific locus, each allele must also occur in...
At the molecular level, flowering is repressed by the protein Flowering Locus C (FLC), which binds to and represses genes that promote flowering, thus...
(IP/99/399) Preliminary results of EU-inspection to Belgium". School of Food Biosciences, University of Reading, UK. Archived from the original on 27 September...
Illumina, Knome, Sequenom, 454 Life Sciences, Pacific Biosciences, Complete Genomics, Helicos Biosciences, GE Global Research (General Electric), Affymetrix...
originates from monoaminorgenic neurons. These neurons are located in the locus coeruleus, dorsal and median raphe nuclei, ventral periaqueductal grey matter...
SpoIIAA is located near the locus for the sigma factor, so it is consistently expressed in the forespore. Since the spoIIAB locus is not located near the...
location of a DNA sequence within a chromosome is known as a locus. If the DNA sequence at a locus varies between individuals, the different forms of this...
pluripotent stem cells for the Asian elephant is reported by Colossal Biosciences, a key step towards de-extinction of the woolly mammoth. 12 March – Geologists...
in the olfactory system. In humans, Gsα is encoded by the GNAS complex locus, while Golfα is encoded by the GNAL gene. The general function of Gs is...
Harvard University. ProQuest 303271509. "University of Chicago - Molecular Biosciences". Archived from the original on 2010-06-10. Retrieved 2010-04-25. Kreitman...
the Origin of Dogs: From Fossils to Genomes". Annual Review of Animal Biosciences. 5: 281–307. doi:10.1146/annurev-animal-022114-110937. PMID 27912242...
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