Green neutrophilic inclusions, death crystals, crystals of death
Critical green inclusions in a neutrophil
Specialty
Hematology
Critical green inclusions, also known as green neutrophilic inclusions and informally, death crystals or crystals of death,[1][2] are amorphous blue-green cytoplasmic inclusions found in neutrophils and occasionally in monocytes. They appear brightly coloured and refractile when stained with Wright-Giemsa stain. These inclusions are most commonly found in critically ill patients, particularly those with liver disease, and their presence on the peripheral blood smear is associated with a high short-term mortality rate.[3][4]
^Soos, M. P.; Heideman, C.; Shumway, C.; Cho, M.; Woolf, A.; Kumar, C. (2019). "Blue-green neutrophilic inclusion bodies in the critically ill patient". Clinical Case Reports. 7 (6): 1249–1252. doi:10.1002/ccr3.2196. PMC 6552944. PMID 31183104.
^Hodgkins, S. R.; Jones, J. "A case of blue-green neutrophil inclusions". ASCLS Today. 32 (4). Archived from the original on 2020-08-06. Retrieved 2019-06-12.
^Hodgson, T. O.; Ruskova, A.; Shugg, C. J.; McCallum, V. J.; Morison, I. M. (2015). "Green neutrophil and monocyte inclusions - time to acknowledge and report". British Journal of Haematology. 170 (2). Wiley: 229–235. doi:10.1111/bjh.13434. ISSN 0007-1048. PMID 25892703. S2CID 23809865.
^Haberichter, K.; Crisan, D. (2017). "Green Neutrophilic Inclusions and Acute Hepatic Failure: Clinical Significance and Brief Review of the Literature". Annals of Clinical and Laboratory Science. 47 (1). Association of Clinical Scientists: 58–61. PMID 28249918.
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