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Lipid polymorphism information


Cross Section view of the structures that can be formed by phospholipids in aqueous solutions

Polymorphism in biophysics is the ability of lipids to aggregate in a variety of ways, giving rise to structures of different shapes, known as "phases". This can be in the form of spheres of lipid molecules (micelles), pairs of layers that face one another (lamellar phase, observed in biological systems as a lipid bilayer), a tubular arrangement (hexagonal), or various cubic phases (Fd3m, Im3m, Ia3m, Pn3m, and Pm3m being those discovered so far). More complicated aggregations have also been observed, such as rhombohedral, tetragonal and orthorhombic phases.

It forms an important part of current academic research in the fields of membrane biophysics (polymorphism), biochemistry (biological impact) and organic chemistry (synthesis).

Determination of the topology of a lipid system is possible by a number of methods, the most reliable of which is x-ray diffraction. This uses a beam of x-rays that are scattered by the sample, giving a diffraction pattern as a set of rings. The ratio of the distances of these rings from the central point indicates which phase(s) are present.

The structural phase of the aggregation is influenced by the ratio of lipids present, temperature, hydration, pressure and ionic strength (and type).

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Lipid polymorphism

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culture media products, and has also been used in extensive studies of lipid polymorphism because this organism alters its ratio of MGlcDG (monoglucosyl diacylglycerol)...

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now been superseded, as through the study of lipid polymorphism it is now known that the behaviour of lipids under physiological (and other) conditions...

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membrane surface, yet the membrane is flexible. These lipids vary in shape (see page on lipid polymorphism). The constituent molecules can inter-mingle easily...

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Hexagonal phase

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of lamellar, micellar and hexagonal phases of lipid bilayer phase behavior and mixed lipid polymorphism in aqueous dispersions can be easily identified...

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Lamellar phase

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theory Lipid polymorphism Lipid bilayer Micelle Unilamellar liposome YashRoy R C (1990) Magnetic resonance studies of dynamic organisation of lipids in chloroplast...

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localization in the plasma membrane, study ion channels, etc. Lipid polymorphism Liposome Lipid bilayer Rideau E, Dimova R, Schwille P, Wurm FR, Landfester...

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Steinmetz A (January 1979). "Polymorphism of apolipoprotein E. III. Effect of a single polymorphic gene locus on plasma lipid levels in man". Clinical Genetics...

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prevent cardiovascular disease in those at high risk and to treat abnormal lipid levels. For the prevention of cardiovascular disease, statins are a first-line...

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micellisation and forms part of the phase behaviour of many lipids according to their polymorphism. The ability of a soapy solution to act as a detergent has...

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protobiont) is a self-organized, endogenously ordered, spherical collection of lipids proposed as a rudimentary precursor to cells during the origin of life....

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gene. As the major component of HDL particles, it has a specific role in lipid metabolism. APOA1 is located on chromosome 11, with its specific location...

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et al. (1995). "Apolipoprotein A-IV polymorphism in the Hungarian population: gene frequencies, effect on lipid levels, and sequence of two new variants"...

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do not, particularly Halobates. Water striders experience wing length polymorphism that has affected their flight ability and evolved in a phylogenetic...

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