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Lewisite information


Lewisite[1]
Lewisite
Names
Preferred IUPAC name
[(E)-2-Chloroethen-1-yl]arsonous dichloride
Other names
Chlorovinylarsine dichloride
2-Chloroethenyldichloroarsine
(E)-2-Chlorovinylarsonous dichloride
(E)-2-Chlorovinyldichloroarsine
Dichloro((E)-2-chlorovinyl)arsine
Identifiers
CAS Number
  • 541-25-3 checkY
3D model (JSmol)
  • Interactive image
ChemSpider
  • 4522971 checkY
MeSH lewisite
PubChem CID
  • 5372798
UNII
  • 82TOY8U2KD checkY
UN number 2810
CompTox Dashboard (EPA)
  • DTXSID301259287 Edit this at Wikidata
InChI
  • InChI=1S/C2H2AsCl3/c4-2-1-3(5)6/h1-2H/b2-1+ checkY
    Key: GIKLTQKNOXNBNY-OWOJBTEDSA-N checkY
  • InChI=1/C2H2AsCl3/c4-2-1-3(5)6/h1-2H/b2-1+
    Key: GIKLTQKNOXNBNY-OWOJBTEDBF
SMILES
  • Cl[As](Cl)\C=C\Cl
Properties
Chemical formula
C2H2AsCl3
Molar mass 207.32 g/mol
Density 1.89 g/cm3
Melting point −18 °C (0 °F; 255 K)
Boiling point 190 °C (374 °F; 463 K)
Solubility in water
Reacts with water
Solubility Ethers, hydrocarbons, THF
Vapor pressure 0.58 mmHg (25 °C)
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
Flammable, highly toxic, corrosive, vesicant
NFPA 704 (fire diamond)
NFPA 704 four-colored diamondHealth 4: Very short exposure could cause death or major residual injury. E.g. VX gasFlammability 1: Must be pre-heated before ignition can occur. Flash point over 93 °C (200 °F). E.g. canola oilInstability 1: Normally stable, but can become unstable at elevated temperatures and pressures. E.g. calciumSpecial hazards (white): no code
4
1
1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
checkY verify (what is checkY☒N ?)
Infobox references

Lewisite (L) (A-243) is an organoarsenic compound. It was once manufactured in the U.S., Japan, Germany[2] and the Soviet Union[3] for use as a chemical weapon, acting as a vesicant (blister agent) and lung irritant. Although the substance is colorless and odorless in its pure form, impure samples of lewisite are a yellow, brown, violet-black, green, or amber oily liquid with a distinctive odor that has been described as similar to geraniums.[4][5][6]

Lewisite is named after the US chemist and soldier Winford Lee Lewis (1878–1943). Apart from its use as a weapon of war, the compound is useless; a chemist from the United States Army's chemical warfare laboratories said that "no one has ever found any use for the compound".[7]

  1. ^ Lewisite I – Compound Summary, PubChem.
  2. ^ Mitchell, Jon (27 July 2013). "A drop in the ocean: the sea-dumping of chemical weapons in Okinawa" – via Japan Times Online.
  3. ^ "Russia Completes Destruction of First 10 Tons of Lewisite – Analysis – NTI". www.nti.org.
  4. ^ Cite error: The named reference nrc was invoked but never defined (see the help page).
  5. ^ "CDC – The Emergency Response Safety and Health Database: Blister Agent: Lewsite (L) – NIOSH". www.cdc.gov. Retrieved 2016-01-14.
  6. ^ Goldman, Max; Dacre, Jack C. (February 14, 1989). Ware, George W. (ed.). "Reviews of Environmental Contamination and Toxicology: Continuation of Residue Reviews". Reviews of Environmental Contamination and Toxicology. 110. Springer: 75–115. doi:10.1007/978-1-4684-7092-5_2. PMID 2692088 – via Springer Link.
  7. ^ Jarman, Gordon N. (January 1, 1959). "Chemical Corps Experience in the Manufacture of Lewisite". Metal-Organic Compounds. Advances in Chemistry. Vol. 23. American Chemical Society. pp. 328–337. doi:10.1021/ba-1959-0023.ch031. ISBN 978-0-8412-0024-1.

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Lewisite

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Dimercaprol

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Dimercaprol, also called British anti-Lewisite (BAL), is a medication used to treat acute poisoning by arsenic, mercury, gold, and lead. It may also be...

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Lewisite 2

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Lewisite 2 (L-2) is an organoarsenic chemical weapon with the formula AsCl(CH=CHCl)2. It is similar to lewisite 1 and lewisite 3 and was first synthesized...

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Lewisite 3

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Lewisite 3 (L-3) is an organoarsenic chemical weapon like lewisite 1 and lewisite 2 first synthesized in 1904 by Julius Arthur Nieuwland. It is usually...

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Blister agent

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similar to the sulfur mustards, but based on nitrogen instead of sulfur. Lewisite – An early blister agent that was developed, but not used, during World...

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Chemical burn

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strong acid, base or oxidizer) or a cytotoxic agent (such as mustard gas, lewisite or arsine). Chemical burns follow standard burn classification and may...

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Chemical weapon

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Health Effects of Mustard Gas and Lewisite (1993). Veterans at Risk: The Health Effects of Mustard Gas and Lewisite. National Academies Press. p. 49....

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Mustard gas

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and lewisite (L), originally intended for use in winter conditions due to its lower freezing point compared to the pure substances. The lewisite component...

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Chelation therapy

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when chemists at the University of Oxford searched for an antidote for lewisite, an arsenic-based chemical weapon. The chemists learned that EDTA was particularly...

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Chemical warfare

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sensors and protective clothing). Examples include nerve agents, ricin, lewisite and mustard gas. Any production over 100 grams (3.5 oz) must be reported...

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Edgewood Arsenal human experiments

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all the experiments done during this period involved mustard agents or Lewisite. Records indicate that between 1955 and 1965, of the 6,720 soldiers tested...

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Arsenic

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chemical warfare agents during World War I, including vesicants such as lewisite and vomiting agents such as adamsite. Cacodylic acid, which is of historic...

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Nazi human experimentation

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subjects were deliberately exposed to mustard gas and other vesicants (e.g. Lewisite), which inflicted severe chemical burns. The victims' wounds were then...

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Tannic acid

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prescribed to treat "burns, whether caused by incendiary bombs, mustard gas, or lewisite". After the war this use was abandoned due to the development of more modern...

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Japanese war crimes

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Imperial Japanese Army resorted to the full-scale use of phosgene, chlorine, Lewisite and nausea gas (red), and from mid-1939, mustard gas (yellow) was used...

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Unit 731

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dedicated to gas experiments. Some of the agents tested were mustard gas, lewisite, cyanic acid gas, white phosphorus, adamsite, and phosgene gas. A former...

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Bal

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lavage, a diagnostic method of the lower respiratory system British anti-Lewisite, or Dimercaprol, a medication to treat acute poisoning Cholate—CoA ligase...

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List of chemical warfare agents

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Methyldichloroarsine (MD) Phenyldichloroarsine (PD) 2-Chlorovinyldichloroarsine (Lewisite; L) The urticants are substances that produce a painful wheal on the skin...

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Winford Lee Lewis

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Organochlorine chemistry

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organochlorine compounds, such as sulfur mustards, nitrogen mustards, and Lewisite, are even used as chemical weapons due to their toxicity. However, the...

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Ethyldichloroarsine (ED) Methyldichloroarsine (MD) Phenyldichloroarsine (PD) Lewisite (L) Mustard gas (HD H HT HL HQ) Nitrogen mustard HN1 HN2 HN3 Phosgene oxime...

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Rudolph Peters

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team at Oxford who developed British Anti-Lewisite (BAL), an antidote for the chemical warfare agent lewisite. His efforts investigating the mechanism...

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HL

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Incapacitating agent

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Ethyldichloroarsine (ED) Methyldichloroarsine (MD) Phenyldichloroarsine (PD) Lewisite (L) Mustard gas (HD H HT HL HQ) Nitrogen mustard HN1 HN2 HN3 Phosgene oxime...

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Battle of Bakhmut

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Russians had attacked them with an arsenic based chemical weapon called lewisite in an artillery bombardment, which had previously been used during World...

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United States and weapons of mass destruction

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S. had begun a large-scale production of Lewisite, for use in an offensive planned for early 1919, Lewisite was not deployed during World War I. The United...

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