phospholipase C-activating G protein-coupled receptor signaling pathway
keratinocyte migration
negative regulation of adenylate cyclase activity
leukotriene signaling pathway
neuropeptide signaling pathway
signal transduction
G protein-coupled receptor signaling pathway
inflammatory response
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
56413
57260
Ensembl
ENSG00000213906 ENSG00000285203
ENSMUSG00000040432
UniProt
Q9NPC1
Q9JJL9
RefSeq (mRNA)
NM_019839 NM_001164692 NM_001164693
NM_020490
RefSeq (protein)
NP_001158164 NP_062813
NP_065236
Location (UCSC)
Chr 14: 24.31 – 24.31 Mb
Chr 14: 56 – 56 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Leukotriene B4 receptor 2, also known as BLT2, BLT2 receptor, and BLTR2, is an Integral membrane protein that is encoded by the LTB4R2 gene in humans and the Ltbr2 gene in mice.[5][6][7]
Discovered several years after the leukotriene B4 receptor 1 (BLT1), BLT2 receptor binds leukotriene B4 (LTB4) with far lower affinity than the BLT1 receptor does and therefore has been termed the low affinity LTB4 receptor. Sometime after its initial discovery, the BLT2 receptor was shown to bind and become activated by several other arachidonic acid metabolites, one of which, 12-hydroxyheptadecatrienoic acid (12-HHT), has 10- to 100-fold higher affinity for it than does LTB4; 12-HHT fails to bind or activate BLT1 receptors. While BLT2 receptors have some actions similar to BLT1 receptors, they have other actions which clearly oppose those of BLT1 in regulating inflammation and allergic responses; BLT2 receptors also have actions that extend beyond those of BLT1 receptors. Laboratory, animal, and other pre-clinical studies suggest that BLT2 receptors may be involved not only in inflammation and allergy but also in human cancer.
^ abcGRCm38: Ensembl release 89: ENSMUSG00000040432 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: LTB4R2 leukotriene B4 receptor 2".
^Wang S, Gustafson E, Pang L, Qiao X, Behan J, Maguire M, Bayne M, Laz T (Dec 2000). "A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization". The Journal of Biological Chemistry. 275 (52): 40686–94. doi:10.1074/jbc.M004512200. PMID 11006272.
^Kato K, Yokomizo T, Izumi T, Shimizu T (Aug 2000). "Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene". The Journal of Experimental Medicine. 192 (3): 413–20. doi:10.1084/jem.192.3.413. PMC 2193224. PMID 10934229.
and 24 Related for: Leukotriene B4 receptor 2 information
LeukotrieneB4receptor2, also known as BLT2, BLT2 receptor, and BLTR2, is an Integral membrane protein that is encoded by the LTB4R2 gene in humans and...
LeukotrieneB4 (LTB4) is a leukotriene involved in inflammation. It has been shown to promote insulin resistance in obese mice. LTB4 is a leukotriene...
proteins: LeukotrieneB4receptors (BLTRs) – bind to and are activated by LTB4: BLT1 (LeukotrieneB4receptor 1) – LTB4R BLT2 (LeukotrieneB4receptor2) – LTB4R2...
Cysteinyl leukotrienereceptors CYSLTR1 and CYSLTR2 are present on mast cells, eosinophil, and endothelial cells. During cysteinyl leukotriene interaction...
antileukotriene, also known as leukotriene modifier and leukotrienereceptor antagonist, is a medication which functions as a leukotriene-related enzyme inhibitor...
of vehicle armour LeukotrieneB4receptor and LeukotrieneB4receptor2, two human genes Lipoxin B4, a lipoxin Proanthocyanidin B4, a B type proanthocyanidin...
Leukotriene A4 (LTA4) is a leukotriene, and is the precursor for the productions of leukotrieneB4 (LTB4) and leukotriene C4 (LTC4). Following the biosynthesis...
cysteinyl leukotrienereceptors (CysLTRs) include the following two receptors: Cysteinyl leukotrienereceptor 1 (CysLTR1) Cysteinyl leukotrienereceptor2 (CysLTR2)...
Montelukast is in the leukotrienereceptor antagonist family of medications. It works by blocking the action of leukotriene D4 in the lungs resulting...
Pharmacological agents that inhibit the function of these leukotrienes are leukotrienereceptor antagonists (e.g., zafirlukast, montelukast) and are useful for asthmatic...
recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2receptors". Proc. Natl. Acad. Sci....
ligand that each binds: Leukotrienes: BLT1 (LeukotrieneB4receptor) – LTB4R; BLT1 is the primary receptor for leukotrieneB4. Relative potencies in binding...
products LTD4 and LTE4. All three leukotrienes then bind at different affinities to two G-protein coupled receptors: CYSLTR1 and CYSLTR2, triggering pulmonary...
Pranlukast (brand name Onon, オノン) is a cysteinyl leukotrienereceptor-1 antagonist. This drug works similarly to Merck & Co.'s montelukast (Singulair)...
Zafirlukast is an orally administered leukotrienereceptor antagonist (LTRA) used for the chronic treatment of asthma. While zafirlukast is generally well...
with 12S-HETE, activates the leukotrieneB4receptor, leukotrieneB4receptor2 (BLT2) but not its leukotrieneB4receptor 1 (BLT1). This allows the possibility...
two compounds are leukotrienereceptor antagonists which block the action of specific leukotrienes, while zileuton inhibits leukotriene formation. Research...
Both variants localize on the endoplasmic reticulum and metabolize leukotrieneB4 and very likely 5-hydroxyeicosatetraenoic acid, 5-oxo-eicosatetraenoic...
which in turn converts to various leukotrienes (i.e., leukotrieneB4, leukotriene C4, leukotriene D4, and leukotriene E4) as well as to 5-hydroxyeicosatetraenoic...
prostaglandins a precursor of the endocannabinoid 2-arachidonoylglycerol an activator of a subfamily of transient receptor potential canonical (TRPC) cation channels...
Azelastine, sold under the brand name Optivar among others, is a H1 receptor-blocking medication primarily used as a nasal spray to treat allergic rhinitis...
Global Information
