ALOX15 information

ALOX15
Identifiers
Aliases	ALOX15, 12-LOX, arachidonate 15-lipoxygenase, LOG15, 15-LOX-1, 15LOX-1, 15-LOX
External IDs	OMIM: 152392; MGI: 87997; HomoloGene: 44935; GeneCards: ALOX15; OMA:ALOX15 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	4,642,294 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	70,242,857 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; oocyte; ; secondary oocyte; ; right uterine tube; ; trachea; ; right lung; ; parietal pleura; ; anterior pituitary; ; pericardium; ; blood;
	Top expressed in
	olfactory epithelium; ; cervix; ; blood; ; corneal stroma; ; lens; ; conjunctival fornix; ; bone marrow; ; esophagus; ; white adipose tissue; ; thymus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	hepoxilin A3 synthase activity; iron ion binding; eoxin A4 synthase activity; dioxygenase activity; hepoxilin-epoxide hydrolase activity; metal ion binding; protein binding; oxidoreductase activity; phosphatidylinositol-4,5-bisphosphate binding; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; lipid binding; arachidonate 15-lipoxygenase activity; arachidonate 12(S)-lipoxygenase activity;
Cellular component	cytoplasm; cytosol; membrane; extrinsic component of cytoplasmic side of plasma membrane; lipid droplet; plasma membrane;
Biological process	cellular response to calcium ion; bone mineralization; leukotriene metabolic process; positive regulation of heterotypic cell-cell adhesion; positive regulation of actin filament polymerization; negative regulation of adaptive immune response; ossification; lipoxin A4 biosynthetic process; lipid metabolism; wound healing; phosphatidylethanolamine biosynthetic process; regulation of peroxisome proliferator activated receptor signaling pathway; response to endoplasmic reticulum stress; fatty acid metabolic process; apoptotic cell clearance; lipoxygenase pathway; hepoxilin biosynthetic process; regulation of engulfment of apoptotic cell; positive regulation of ERK1 and ERK2 cascade; inflammatory response; cellular response to interleukin-13; positive regulation of cell-substrate adhesion; arachidonic acid metabolic process; cytokine-mediated signaling pathway; long-chain fatty acid biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	246
	11687
	ENSG00000161905
	ENSMUSG00000018924
	P16050
	P39654
	NM_001140
	NM_009660
	NP_001131
	NP_033790
	Wikidata
View/Edit Human	View/Edit Mouse

The arachidonate 15-lipoxygenase of the European rabbit

ALOX15 (also termed arachidonate 15-lipoxygenase, 15-lipoxygenase-1, 15-LO-1, 15-LOX-1) is, like other lipoxygenases, a seminal enzyme in the metabolism of polyunsaturated fatty acids to a wide range of physiologically and pathologically important products. ▼ Gene Function

Kelavkar and Badr (1999) stated that the ALOX15 gene product is implicated in antiinflammation, membrane remodeling, and cancer development/metastasis. Kelavkar and Badr (1999) described experiments yielding data that supported the hypothesis that loss of the TP53 gene, or gain-of-function activities resulting from the expression of its mutant forms, regulates ALOX15 promoter activity in human and in mouse, albeit in directionally opposite manners. These studies defined a direct link between ALOX15 gene activity and an established tumor-suppressor gene located in close chromosomal proximity. Kelavkar and Badr (1999) referred to this as evidence that 15-lipoxygenase is a mutator gene. ▼ Mapping

By PCR analysis of a human-hamster somatic hybrid DNA panel, Funk et al. (1992) demonstrated that genes for 12-lipoxygenase and 15-lipoxygenase are located on human chromosome 17, whereas the most unrelated lipoxygenase (5-lipoxygenase) was mapped to chromosome 10.

Kelavkar and Badr (1999) stated that the ALOX15 gene maps to 17p13.3 in close proximity to the tumor-suppressor gene TP53 (191170). In humans, it is encoded by the ALOX15 gene located on chromosome 17p13.3.^[5] This 11 kilobase pair gene consists of 14 exons and 13 introns coding for a 75 kilodalton protein composed of 662 amino acids. 15-LO is to be distinguished from another human 15-lipoxygenase enzyme, ALOX15B (also termed 15-lipoxygenase-2).^[6] Orthologs of ALOX15, termed Alox15, are widely distributed in animal and plant species but commonly have different enzyme activities and make somewhat different products than ALOX15.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000161905 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018924 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Funk CD, Funk LB, FitzGerald GA, Samuelsson B (May 1992). "Characterization of human 12-lipoxygenase genes". Proceedings of the National Academy of Sciences of the United States of America. 89 (9): 3962–6. Bibcode:1992PNAS...89.3962F. doi:10.1073/pnas.89.9.3962. PMC 525611. PMID 1570320.
^ Ivanov I, Kuhn H, Heydeck D (November 2015). "Structural and functional biology of arachidonic acid 15-lipoxygenase-1 (ALOX15)". Gene. 573 (1): 1–32. doi:10.1016/j.gene.2015.07.073. PMC 6728142. PMID 26216303.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000161905 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000018924 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1570320-5] Funk CD, Funk LB, FitzGerald GA, Samuelsson B (May 1992). "Characterization of human 12-lipoxygenase genes". Proceedings of the National Academy of Sciences of the United States of America. 89 (9): 3962–6. Bibcode:1992PNAS...89.3962F. doi:10.1073/pnas.89.9.3962. PMC 525611. PMID 1570320.

[Gene_2015-6] Ivanov I, Kuhn H, Heydeck D (November 2015). "Structural and functional biology of arachidonic acid 15-lipoxygenase-1 (ALOX15)". Gene. 573 (1): 1–32. doi:10.1016/j.gene.2015.07.073. PMC 6728142. PMID 26216303.

ALOX15 information

and 16 Related for: ALOX15 information

ALOX15

Lipoxygenase

Eicosanoid

Arachidonic acid

ALOX12

Resolvin

ALOX15B

Chemotaxis

Maresin

NSAID hypersensitivity reactions

Lipoxin

ALOXE3

PLAT domain

Eoxin

Hepoxilin

Joseph Grinnell