Laser speckle contrast imaging (LSCI), also called laser speckle imaging (LSI), is an imaging modality based on the analysis of the blurring effect of the speckle pattern. The operation of LSCI is having a wide-field illumination of a rough surface through a coherent light source. Then using photodetectors such as CCD camera or CMOS sensors imaging the resulting laser speckle pattern caused by the interference of coherent light.[1][2] In biomedical use, the coherent light is typically in the red or near-infrared region to ensure higher penetration depth.[3] When scattering particles moving during the time, the interference caused by the coherent light will have fluctuations which will lead to the intensity variations detected via the photodetector, and this change of the intensity contain the information of scattering particles' motion.[4] Through image the speckle patterns with finite exposure time, areas with scattering particles will appear blurred.
^Davis, Mitchell A.; Kazmi, S. M. Shams; Dunn, Andrew K. (August 2014). "Imaging depth and multiple scattering in laser speckle contrast imaging". Journal of Biomedical Optics. 19 (8): 086001. Bibcode:2014JBO....19h6001D. doi:10.1117/1.JBO.19.8.086001. ISSN 1083-3668. PMC 4119427. PMID 25089945.
^Cite error: The named reference :4 was invoked but never defined (see the help page).
^Dunn, Andrew K. (February 2012). "Laser Speckle Contrast Imaging of Cerebral Blood Flow". Annals of Biomedical Engineering. 40 (2): 367–377. doi:10.1007/s10439-011-0469-0. ISSN 0090-6964. PMC 3288249. PMID 22109805.
^Boas, David A.; Dunn, Andrew K. (January 2010). "Laser speckle contrast imaging in biomedical optics". Journal of Biomedical Optics. 15 (1): 011109–011109–12. Bibcode:2010JBO....15a1109B. doi:10.1117/1.3285504. ISSN 1083-3668. PMC 2816990. PMID 20210435.
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