Global InformationLaser diode thermal desorption information
Laser diode thermal desorption (LDTD) is an ionization technique that is coupled to mass spectrometry to analyze samples with atmospheric pressure chemical ionization (APCI). It uses a laser to thermally desorb analytes that are deposited on a stainless steel sheet sample holder, called LazWell.[1] The coupling of LDTD and APCI is considered to be a soft-ionization technique.[2] With LDTD-APCI, it is possible to analyze samples in forensics,[3] pharmaceuticals,[4] environment,[5] food[6] and clinical studies.[7] LDTD is suitable for small molecules[7] between 0 and 1200 Da and some peptides such as cyclosporine.[8]
- ^ Wu, Jin; Hughes, Christopher S.; Picard, Pierre; Letarte, Sylvain; Gaudreault, Mireille; Lévesque, Jean-François; Nicoll-Griffith, Deborah A.; Bateman, Kevin P. (June 2007). "High-Throughput Cytochrome P450 Inhibition Assays Using Laser Diode Thermal Desorption-Atmospheric Pressure Chemical Ionization-Tandem Mass Spectrometry". Analytical Chemistry. 79 (12): 4657–4665. doi:10.1021/ac070221o. ISSN 0003-2700. PMID 17497828.
- ^ Borik, A.; Vojs Stanova, A.; Kodesova, R.; Brooks, B. W.; Grabicova, K.; Novakova, P.; Grabic, R. (2020-02-01). "Ultrafast laser diode thermal desorption method for analysis of representative pharmaceuticals in soil leachate samples". Talanta. 208: 120382. doi:10.1016/j.talanta.2019.120382. ISSN 0039-9140. PMID 31816693. S2CID 203936286.
- ^ Bynum, Nichole D.; Moore, Katherine N.; Grabenauer, Megan (2014-10-01). "Evaluation of Laser Diode Thermal Desorption–Tandem Mass Spectrometry (LDTD–MS-MS) in Forensic Toxicology". Journal of Analytical Toxicology. 38 (8): 528–535. doi:10.1093/jat/bku084. ISSN 0146-4760. PMID 25217542.
- ^ Heudi, Olivier; Barteau, Samuel; Picard, Pierre; Tremblay, Patrice; Picard, Franck; Kretz, Olivier (2011-04-05). "Laser diode thermal desorption–positive mode atmospheric pressure chemical ionization tandem mass spectrometry for the ultra-fast quantification of a pharmaceutical compound in human plasma". Journal of Pharmaceutical and Biomedical Analysis. 54 (5): 1088–1095. doi:10.1016/j.jpba.2010.11.025. ISSN 0731-7085. PMID 21156343.
- ^ Mohapatra, D. P.; Brar, S. K.; Tyagi, R. D.; Picard, P.; Surampalli, R. Y. (2012-09-15). "Carbamazepine in municipal wastewater and wastewater sludge: Ultrafast quantification by laser diode thermal desorption-atmospheric pressure chemical ionization coupled with tandem mass spectrometry". Talanta. 99: 247–255. doi:10.1016/j.talanta.2012.05.047. ISSN 0039-9140. PMID 22967548.
- ^ Andersen, Wendy C.; VanSickle, Michael; Storey, Joseph; Sheldon, Virginia; Lohne, Jack; Turnipseed, Sherri B.; Thomas, Terri; Madson, Mark (2019-11-02). "Fast analysis of caffeinated beverages using laser diode thermal desorption mass spectrometry (LDTD-MS/MS)". Food Additives & Contaminants: Part A. 36 (11): 1616–1625. doi:10.1080/19440049.2019.1658904. ISSN 1944-0049. PMID 31479386. S2CID 201829502.
- ^ a b Lanshoeft, Christian; Heudi, Olivier; Leuthold, Luc Alexis; Schlotterbeck, Götz; Elbast, Walid; Picard, Franck; Kretz, Olivier (2014-09-01). "Laser diode thermal desorption atmospheric pressure chemical ionization tandem mass spectrometry applied for the ultra-fast quantitative analysis of BKM120 in human plasma". Analytical and Bioanalytical Chemistry. 406 (22): 5413–5423. doi:10.1007/s00216-014-7966-6. ISSN 1618-2650. PMID 24958346. S2CID 2923544.
- ^ Jourdil, Jean-François; Picard, Pierre; Meunier, Cécile; Auger, Serge; Stanke-Labesque, Françoise (2013-12-17). "Ultra-fast cyclosporin A quantitation in whole blood by Laser Diode Thermal Desorption – Tandem Mass Spectrometry; comparison with High Performance Liquid Chromatography–Tandem Mass Spectrometry". Analytica Chimica Acta. 805: 80–86. doi:10.1016/j.aca.2013.10.051. ISSN 0003-2670. PMID 24296146.